High-Fat/High-Sugar Diet Causes Metabolic Disorders and Cardiac Dysfunction: a New Model in Primates

Qiu, Yan; Xu, Gui-e; Xiao, Junjie

doi:10.1007/s12265-021-10119-7

Cited by 3 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amounts of most conjugated BAs are negatively correlated with Chloroflexi and Prevotella prevalence in frugivores ( Figure 4A ). While high-sugar diets cause metabolic disorders ( Qiu et al, 2021 ), aggravate chronic colitis, and increase the incidence of colitis related tumors (51), Prevotella (Bacteroidetes) can help degrade simple sugars and carbohydrates, alleviating the adverse effects of fruit-derived sugars ( Lambert, 1998 ; Kim et al, 2011 ; Ni et al, 2014 ; Dooley and Judge, 2015 ; Hon et al, 2018 ; Hale et al, 2019 ). CDCA, a metabolite associated with glucose and lipid metabolism regulation ( Yu et al, 2015 ), is positively correlated with Phascolarctobacterium (Negativicutes) in frugivores.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Gut Microbiome and Bile Acids in Primates With Diverse Diets

Wang

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Primates have evolved a variety of feeding habits and intestinal physiological structure. Gut microbiome act as metabolic organs in many biological processes and play a vital role in adaptation to dietary niches. Gut microbiome also convert primary bile acids (BAs) to secondary. BAs profile and gut microbiome are together influenced by diets and play a significant role in nutrient absorption. The regulation between gut microbiome and BAs metabolism is bidirectional although the relationship in primates consuming diverse diets is still unclear. Here, we investigated gut microbiome structures, fecal BAs profile, and their relationship in primates preferring three distinct diets. We found that gut microbiome communities are well differentiated among dietary groups. Folivorous primates had higher Firmicutes abundance and lower Prevotella to Bacaeroides ratios, possibly related to fiber consumption. Frugivorous primates are colonized predominantly by Prevotella and Bacteroides, pointing to an increased adaptation to high-sugar and simple carbohydrate diets. Likewise, BA profiles differ according to diet in a manner predictable from the known effects of BAs on metabolism. Folivorous primates have high conjugated bile acid levels and low unconjugated to conjugated BA ratios, consistent with their fiber-rich leaf-eating diet. Much of the differentiation in secondary and unconjugated BAs is associated with microbiome composition shifts and individual bile acid concentrations are correlated with the abundance of distinct bacterial taxonomic groups. Omnivores have higher concentrations of secondary BAs, mainly lithocholic acid (LCA). These levels are significantly positively correlated with the presence of Clostrida species, showing that the digestion requirements of omnivores are different from plant-eating primates. In conclusion, gut microbiome and BAs can respond to changes in diet and are associated with nutrient component consumption in each diet primate group. Our study is the first to demonstrate BA profile differentiation among primates preferring diverse diets. BAs thus appear to work with gut microbiome to help primates adapt to their diet.

show abstract

Section: Discussionmentioning

confidence: 99%

The Relationship Between Gut Microbiome and Bile Acids in Primates With Diverse Diets

Wang

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The Editorial Team acknowledged the value of this exciting animal model of elderly heart failure, especially to explore the molecular mechanisms of elderly cardiac dysfunction upon high-fat diet administration [8]. Similar to humans in anatomy, physiology, metabolism, and genetics, NHPs have been used for decades to understand the pathogenesis of cardiovascular disease.…”

mentioning

confidence: 99%

Best Paper of the Year 2021

Xiao

Lara‐Pezzi

2022

J. of Cardiovasc. Trans. Res.

Self Cite

View full text Add to dashboard Cite

We are excited to present a new section in JCTR that highlights the best papers of the previous year. The following articles were selected by the associate editors from those accepted during 2021 and based on their relevance, impact, and how they contribute to the Journal's aims. We believe that they showcase the quality and diversity of the papers published in JCTR. Best Paper of the Year-Aged monkeys fed a high-fat/high-sugar diet recapitulate metabolic disorders and cardiac contractile dysfunction, by Shuang Zheng and colleagues [1].

show abstract

Polysaccharides from Lactarius volemus Fr. ameliorate high-fat and high-fructose diet induced metabolic disorders and intestinal barrier dysfunction

Xu,

Zhang,

Zhou

et al. 2025

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

High-Fat/High-Sugar Diet Causes Metabolic Disorders and Cardiac Dysfunction: a New Model in Primates

Cited by 3 publications

References 3 publications

The Relationship Between Gut Microbiome and Bile Acids in Primates With Diverse Diets

The Relationship Between Gut Microbiome and Bile Acids in Primates With Diverse Diets

Best Paper of the Year 2021

Polysaccharides from Lactarius volemus Fr. ameliorate high-fat and high-fructose diet induced metabolic disorders and intestinal barrier dysfunction

Contact Info

Product

Resources

About