2013
DOI: 10.1007/s00259-013-2429-4
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High FDG activity in focal fat necrosis: a pitfall in interpretation of posttreatment PET/CT in patients with non-Hodgkin lymphoma

Abstract: Although rare, identification of fat necrosis in patients with a solitary FDG-avid nodule after therapy is important and may lead to the avoidance of unnecessary interventions or treatment. Specific features on CT aid identification, whilst follow-up imaging can be helpful as the metabolic abnormality regresses with time.

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Cited by 19 publications
(12 citation statements)
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“…Due to not specific nature of the tracer used, there is a high likelihood for false-positive PET findings during treatment (e.g., brown fatty tissue, fat necrosis, inflammation, reactive lymph nodes, thymus rebound, and diffuse bone marrow uptake after administration of hematopoietic growth factors) [27-29]. A high number of false-positive findings (26/38) has also been reported by Moskowitz et al in a prospective series [19].…”
Section: Resultsmentioning
confidence: 99%
“…Due to not specific nature of the tracer used, there is a high likelihood for false-positive PET findings during treatment (e.g., brown fatty tissue, fat necrosis, inflammation, reactive lymph nodes, thymus rebound, and diffuse bone marrow uptake after administration of hematopoietic growth factors) [27-29]. A high number of false-positive findings (26/38) has also been reported by Moskowitz et al in a prospective series [19].…”
Section: Resultsmentioning
confidence: 99%
“…FDG-avidity should be very closely matched to the sites of CT density and if performed for prior pleural malignancy, sites of pleural uptake with corresponding CT density should be considered to be malignant deposits Post radiotherapy inflammatory change Geographic (linear) change conforming to the radiation treatment field. Surrounding very low grade ‘haze’ of uptake within muscle and soft tissue can be apparent Fat necrosis Most commonly located in mesenteric fat after therapy in patients with lymphoma [ 10 ]. Focal moderate-to-intense uptake corresponding to nodule with density between that of soft tissue and fat.…”
Section: Introductionmentioning
confidence: 99%
“…Detailed knowledge of the anatomic appearance of pathologic, inflammatory and benign processes is therefore critical to correctly interpret PET/CT. For example, focal intense abnormality on PET alone indicative of residual or recurrent lymphoma, may be revised to fat necrosis when CT appearances are integrated [ 10 ]. Likewise, lack of uptake in a lymph node may be revised from benign to malignant when the CT appearances of contrast enhancement rim enhancement and necrosis are integrated.…”
Section: Introductionmentioning
confidence: 99%
“…Diffuse FDG uptake in the stomach, in the gastroesophageal junction, or gastric antrum is usually related to different benign disease like inflammation due to intermittent gastroesophageal reflux disease, subclinical infection with Helicobacter pylori or secondary effects of chemotherapeutic agent [29]. Focal uptake in mesenteric fat due to mesenteric panniculitis or fat necrosis can mimic nodal involvement [30]. Potential imaging pitfalls in PET/ CT interpretation include brown fat FDG uptake, bone marrow, and splenic activation [28].…”
Section: How To Interpret Staging Pet/ct In Lymphoma Patientsmentioning
confidence: 99%