High fiber diet attenuate the inflammation and adverse remodeling of myocardial infarction via modulation of gut microbiota and metabolites

Zhao, Jinxuan; Cheng, Wei; Li, He; Shan, Anqi; Zhang, Qi; Sun, Xuan; Lee, Kang; Xie, Jun; Xu, Baojun

doi:10.3389/fmicb.2022.1046912

Cited by 11 publications

(9 citation statements)

References 42 publications

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“…Notably, there is a gap in the literature regarding the relationship between visfatin and subclinical atherosclerosis concerning protein intake. Dietary fiber, known for its anti-inflammatory properties, is protective against myocardial infarction [ 53 ]. Although one study showed no correlation between visfatin and fiber intake [ 23 ], our research identified a significant association between visfatin and IMT in individuals with insufficient dietary fiber, supporting existing evidence for the cardiovascular benefits of adequate fiber consumption [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Unlocking the Dietary Puzzle: How Macronutrient Intake Shapes the Relationship between Visfatin and Atherosclerosis in Type 2 Diabetes

Kärberg,

Forbes,

Lember

2024

Medicina

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Background and Objectives. Optimal nutrition for type 2 diabetes (T2DM) aims to improve glycemic control by promoting weight loss and reducing adipose tissue, consequently improving cardiovascular health. Dietary alterations can influence adipose tissue metabolism and potentially impact adipocytokines like visfatin, thereby affecting atherosclerosis development. This study aimed to investigate dietary habits and adherence to recommendations among individuals with T2DM and to examine how dietary adherence influences the association between visfatin and subclinical atherosclerosis. Materials and Methods: This cross-sectional multicenter study involved 216 adults (30–70 years) with T2DM, assessing dietary habits, adherence to recommendations (carbohydrates, fats, protein, fiber, saturated fatty acid, polyunsaturated and monounsaturated fatty acid (PUFA and MUFA) and salt), and the association between visfatin and subclinical atherosclerosis. Participants completed 24 h dietary recalls; dietary misreporting was assessed using the Goldberg cut-off method. Carotid intima–media thickness (IMT) and plaque occurrence were evaluated with ultrasound, while visfatin levels were measured using Luminex’s xMAP technology. Results: Three of the eight recommendations were followed in 31% of subjects, two in 26%, and four in 20%, with the highest adherence to MUFA and protein intake. Significant correlations between IMT and visfatin were observed in individuals with specific dietary patterns. The association between IMT and visfatin persisted when PUFA and MUFA intake aligned with recommendations. PUFA intake ≤ 10% and MUFA ≤ 20% of total energy significantly correlated with carotid artery IMT (p = 0.010 and p = 0.006, respectively). Visfatin’s associations with IMT remained significant (p = 0.006) after adjusting for common risk factors, medication use, and dietary nonadherence. No association was observed with carotid artery plaque. Conclusions: Dietary compliance was limited, as only 31% adhered even to three of eight recommendations. A common dietary pattern characterized by low carbohydrate and fiber but high fat, total fat, saturated fat, and salt intake was identified. This pattern amplifies the statistical association between visfatin and subclinical atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Unlocking the Dietary Puzzle: How Macronutrient Intake Shapes the Relationship between Visfatin and Atherosclerosis in Type 2 Diabetes

Kärberg,

Forbes,

Lember

2024

Medicina

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“… 31 In addition, gut linoleic acid and alpha linolenic acid metabolism pathways were found to be involved in anti-inflammatory and antioxidative effects. 32 , 33 Sphingolipid metabolism has been implicated in gut immune reactions and is mediated by extracorporeal and intracorporeal factors. 34 The enrichment of pathways, related to phenylalanine metabolism, linoleic acid, alpha linolenic acid and sphingolipid metabolism in the study, may imply a role in repairing and promoting gut recovery following radioactive iodine therapy, worthy of further exploration.…”

Section: Discussionmentioning

confidence: 99%

Changes in Gut Microbiota and Metabolites in Papillary Thyroid Carcinoma Patients Following Radioactive Iodine Therapy

Li,

Cheng,

Zhang

et al. 2023

IJGM

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Purpose Radioactive iodine therapy is administered through oral route, which is accumulated and absorbed in the intestine. However, its effects on the intestine remain unclear. In this study, we investigated the changes in the gut microbiota and metabolites following radioactive iodine therapy. Patients and Methods A total of 76 stool samples from the same 38 patients were collected at the start of radioactive iodine therapy and three days following the therapy. Stool microbiota and metabolites were detected using 16S rRNA gene sequencing and liquid chromatography-mass spectrometry. Results Enterobacteriales, Enterobacteriaceae and Escherichia-Shigella were elevated in most patients (27/38) following the therapy. The levels of 2-hydroxyundec-7-enoylcarnitine were significantly lower, whereas those of 5-dehydroavenasterol, butylisopropylamine, and salsoline-1-carboxylate were higher following the therapy. The relative abundance of Escherichia-Shigella was negatively correlated with 2-hydroxyundec-7-enoylcarnitine level (r 2 = −0.661, P = 0.009). Functional pathways were predicted to be involved in amino acid and lipid metabolism following the therapy. Particularly, phenylalanine, linoleic acid, sphingolipid, purine, and alpha-linolenic acid metabolism were the main metabolic pathways. Conclusion Gut microbiota was disturbed following radioactive iodine therapy, with increased Escherichia-Shigella . Processes associated with energy production seems to be impacted following the therapy, with significantly decreased 2-hydroxyundec-7-enoylcarnitine level. Meanwhile, some metabolites and functional pathways may have a positive effect on intestinal homeostasis, and may be related to the repair and promotion of gut recovery following the therapy. This study provides a basic foundation to explore how radioactive iodine affects gut microbiota and metabolites, and how gut function is regulated in response to radioactive iodine therapy.

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“…In other words, the causal relationship between serum levels of carotenoids and CVD prevalence has not been fully understood. Additionally, other dietary or environmental factors (e.g., artificial sweeteners, vitamin D, dietary fiber, and heavy metals) may still have influences on the conclusions even after model adjustment as carotenoids are mainly obtained from fruits and vegetables (41)(42)(43)(44). The limitations of the WQS regression analysis may also affect the conclusions as the all-positive and all-negative dependent variables have the same effects on exposure.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population

et al. 2023

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BackgroundCardiovascular disease (CVD) has become a key global health issue. Serum carotenoids are associated with CVD, while their effects on different diseases remain unclear. Herein, the relationship between the concentration of serum carotenoid and the CVD risk was investigated using nationwide adult samples obtained from the USA.Materials and methodsData of National Health and Nutrition Examination Survey (NHANES) in 2001–2006 were employed. The association of serum carotenoids (total, lycopene, β-carotene, α-carotene, lutein/zeaxanthin, and β-cryptoxanthin) with CVD was explored by using multivariate logistic, linear and weighted quantile sum (WQS) regression analyses. Eventually, data from 12,424 volunteers were analyzed for this study.ResultsMultivariate model data showed that lutein/zeaxanthin, α-carotene, lycopene, and β-cryptoxanthin were negatively associated with the prevalence of CVD (p < 0.05). In comparison with the first quartile, the fourth quartile was associated with α-carotene ([OR] = 0.61 [0.47–0.79]), β-cryptoxanthin (OR = 0.67 [0.50–0.89]), lutein (OR = 0.69 [0.54–0.86]), and lycopene (OR = 0.53 [0.41–0.67]). WQS analysis revealed that the combination of serum carotenoids had negative correlation with the prevalence of total CVD (OR = 0.88, 95% CI: 0.85–0.92, p < 0.001). Additionally, dose–response analysis demonstrated a negative linear association of hypertension with all the carotenoids involved (p > 0.05 for non-linearity).ConclusionThe concentration of serum carotenoids had negative correlation with the prevalence of CVD, with a more significant negative effect against heart attack and stroke.

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High fiber diet attenuate the inflammation and adverse remodeling of myocardial infarction via modulation of gut microbiota and metabolites

Cited by 11 publications

References 42 publications

Unlocking the Dietary Puzzle: How Macronutrient Intake Shapes the Relationship between Visfatin and Atherosclerosis in Type 2 Diabetes

Unlocking the Dietary Puzzle: How Macronutrient Intake Shapes the Relationship between Visfatin and Atherosclerosis in Type 2 Diabetes

Changes in Gut Microbiota and Metabolites in Papillary Thyroid Carcinoma Patients Following Radioactive Iodine Therapy

The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population

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