High Fibre Diets and Alzheimer’s Disease

2016

Health

Self Cite

In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer's disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions with the prevention of myocardial infarction and Type 3 diabetes. Magnesium deficiency and its effects on Sirt1 regulation have become important with magnesium deficiency associated with appetite dysregulation, senescence, glucose/nitric oxide dyshomeostasis, increased ceramide and toxic amyloid beta formation. Magnesium therapy activates the peripheral sink amyloid beta clearance pathway with the reversal of cell senescence associated with various chronic diseases such as cardiovascular disease, Type 3 diabetes and Alzheimer's disease.

Section: Magnesium Therapy Regulates Amyloid Beta Metabolism With Impmentioning

confidence: 99%

Section: Unhealthy Diets Exercise and Stress Prevent Magnesium Theramentioning

confidence: 99%

Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease

2016

Health

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“…The peripheral clearance of Aβ and its relationship to high fibre diets [52] has now become of particular interest to neurodegenerative diseases such as PD and AD. Nutriproteomic diets (Figure 1) that are low in fat and glucose activates the liver and brain anti-aging protein Sirt 1 [53]- [55] and accelerates Aβ and cholesterol metabolism.…”

Section: Hepatic Release Of Acute Phase Proteins and Cytokines Is Regmentioning

confidence: 99%

LPS Regulates Apolipoprotein E and A<i>β</i> Interactionswith Effects on Acute Phase Proteins and Amyloidosis

2015

AAR

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Interactions between apolipoprotein E (apo E) and amyloid beta (Aβ) are associated with the peripheral clearance of Aβ and are important to the development of neurodegenerative diseases. Interests in acute phase proteins (APP) as biomarkers for the early progression of Alzheimer's disease indicate that the peripheral Aβ metabolism is perturbed and the role of nutritional diets are important to reduce APPs to maintain peripheral Aβ clearance with relevance to hepatic cholesterol homeostasis and brain amyloidosis. The role of nutriproteomic diets that reverse the effects of high fat diets are associated with the reduction in APPs, cholesterol homeostasis and improved clearance of Aβ. Nutritional diets that reduce the increase in plasma endotoxins (gut microbiotica) such as lipopolysaccarides (LPS) reduce the effects of LPS on cell membranes and increase the cellular uptake of Aβ by interactions with apo E. LPS alter hepatic lipid metabolism with an increase hepatic cytokines and APPs in plasma. Interactions between apo E and Aβ are altered by LPS with increased binding of LPS to apo E with effects on electrostatic alterations in Aβ oligomers. The role of LPS in neurodegenerative diseases includes the effects of LPS on alpha-synuclein metabolism with relevance to Parkinson's disease and Alzheimer's disease.

“…Activation of nuclear receptors such as the Sirt1/PXR and G coupled receptors by calorie restriction (low glycemic index) is important to the science of nutrigenomics [179] with relevance of specific nutrients in the treatment of NAFLD and induction of obesity. Fruits such as apples contain pyruvic acid (450 mg/apple) an antioxidant that is an activator of Sirt1 [180] [181] and is essential for NAFLD treatment.…”

Section: Nutritional Interventions Reverse Nafld With the Prevention mentioning

confidence: 99%

“…High fibre diets [179] that contain fruit and vegetables have become important for the treatment of NAFLD with the reduction in the fat content of tissues such as the liver and adipose tissue and prevention of various chronic diseases (Figure 3). Activation of nuclear receptors such as the Sirt1/PXR and G coupled receptors by calorie restriction (low glycemic index) is important to the science of nutrigenomics [179] with relevance of specific nutrients in the treatment of NAFLD and induction of obesity.…”

Section: Nutritional Interventions Reverse Nafld With the Prevention mentioning

confidence: 99%

Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries

2014

OJEMD

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The susceptibility of individuals to obesity has been reported in many developed countries with predisposition of humans to obesity associated with high calorie diets and unhealthy lifestyles. Obesity may closely be involved in cell suicide in various organ diseases with the importance of accelerated aging that requires early intervention with drug therapy to prevent diseases such as non alcoholic fatty liver disease (NAFLD) that has increased in children and reached to approx. 40% of the global population. Obesity is induced by various diets and lifestyle factors such as stress, anxiety and depression which are important to consider with the global increase in obesity and are possibly linked to the rise in individuals with brain disorders that involve neurodegeneration. Xenobiotics such as the endocrine disruptor chemicals that have increased in the environment in various developed countries lead to various chronic endocrine diseases as populations divert towards unhealthy diets and lifestyles with induction of NAFLD and obesity. The amount and nature of food intake that improves and increases liver lipid and xenobiotic metabolism in obese individuals have become important to decrease the risk for increased adiposity in man. High fibre or protein diets that contain leucine may improve liver glucose, lipid and xenobiotic metabolism and require further investigation with xenobiotics such as endocrine disruptors involved in appetite dysregulation and metabolic disorders in developed countries. The use of anti-obese drugs that reduce food intake and improve hypercholesterolemia and cardiovascular disease has been assessed in obesity with drug therapy closely involved either in the prevention or induction of NAFLD and obesity in man.