High‐Fidelity Far‐Field Microscopy at λ/8 Resolution

Xu, Ning; Liu, Guoxuan; Tan, Qiaofeng

doi:10.1002/lpor.202200307

Cited by 7 publications

(2 citation statements)

References 48 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An alternative approach to resolution enhancement is to decrease the size of the focused illumination spot [11][12][13]. As originally proposed by Toraldo di Francia [11], resolution enhancement can be achieved by pupil filtering techniques.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, phase-only diffractive optical elements (DOEs) modulate the optical wavefront to generate custom diffraction patterns, with examples including extended depth of focus beams [14,15], axial multi-focus spots [16], super-resolution hollow beams [17], and magnification of the diffraction field [18]. DOEs can be used to reduce the focused spot size (or spot array) to smaller than the Abbe-Rayleigh diffraction limit [12,13,19,20]. This approach exploits the phenomenon of optical super-oscillations [21], in which a complex bandlimited signal can locally oscillate much faster than its highest Fourier components.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resolution-enhanced imaging for endoscopy using diffractive optics

Xu¹,

Williams²,

Spicer

et al. 2022

Advanced Optical Imaging Technologies V

View full text Add to dashboard Cite

Optical endoscopy is indispensable for minimally-invasive medical diagnostics and therapeutics, whereby visualization of subtle changes in the structure of tissue can be used to identify disease. Adaptive real-time zoom functionality is highly desirable for resolving mucosal microvasculature, which when visualized can be used to improve diagnostic accuracy. Realizing this functionality in state-of-the-art miniaturized endoscopic imaging, such as chip-on-tip endoscopes, is challenging: conventional zoom objectives are bulky and existing chip-on-tip systems still have far from diffraction-limited performance. Point-scanning illumination approaches have been shown to improve imaging resolution by reducing the focused spot size. Typically, this higher resolution comes at the cost of low optical throughput (efficiency) and long acquisition times due to mechanical scanning requirements, thereby limiting applicability in clinical settings. In this work, we demonstrate an innovative Diffractive Optical Element (DOE) based optical imaging system for spatial resolution enhancement without mechanical scanning. Our imaging system is based on simultaneous utilization of a custom DOE and high-speed Digital Micromirror Device (DMD). The multi-level phase-only DOE produces a single super-resolution spot in the far-field while the DMD laterally scans the spot in the object plane at kHz rates. To demonstrate resolution enhancement with high-speed acquisition, we image a resolution test target and fluorescently labelled cells. In the future, through envisioned DOE-array integration in an endoscopic module, resolution enhancement (in an adaptive zoom-mode) can be achieved through illumination modulation alone without the need for separate systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resolution-enhanced imaging for endoscopy using diffractive optics

Xu¹,

Williams²,

Spicer

et al. 2022

Advanced Optical Imaging Technologies V

View full text Add to dashboard Cite

show abstract

Multiwavelength Achromatic Metalens in Visible by Inverse Design

Jiang

Liu

et al. 2023

Advanced Optical Materials

View full text Add to dashboard Cite

Achromatic metalenses are promising alternatives to traditional lenses, allowing the miniaturization of optical systems. However, the limitation due to the group delay range of the meta‐atoms that can be fabricated requires a trade‐off relationship between the working bandwidth, numerical aperture (NA), and aperture of the achromatic metalens operating in a continuous spectrum. Considering that light sources used in most optical systems to illuminate or display images in most optical systems generate multiwavelength light with a narrow bandwidth, an efficient end‐to‐end inverse design framework for multiwavelength achromatic metalenses is implemented. As a proof of concept, an achromatic metalens with an NA of 0.3 and a diameter of 115 µm at four visible wavelengths and arbitrary linear polarization is designed and experimentally demonstrated. The measured results show a maximum focal length shift of 5.2778%. The proposed strategy avoids complicated physical models, enabling the integration of complex functionalities into a single metasurface, thereby driving the design of efficient and emerging devices.

show abstract

Optical Super‐Oscillation Enables Sub‐Diffraction Focusing and Super‐Resolution Imaging in the Far‐Field

Li,

Zang,

Hai

et al. 2024

Annalen der Physik

View full text Add to dashboard Cite

Owing to the inherent wave property of light, the resolution of the optical system is constrained by the diffraction limit. Past decades have seen many efforts to break the diffraction limit at the expense of complex near‐field manipulation, pre‐labeling, or post‐processing. However, an optical access for noninvasive sub‐diffraction focusing and super‐resolution imaging in the far‐field that does not pose dependency on evanescent waves or targets is still highly desirable. Optical super‐oscillation method based on the superposition of propagating waves offers a possibility to overcome the diffraction limit in the far‐field with arbitrary enhanced resolution. This article reviews the recent progress of optical super‐oscillation technology, including research about super‐oscillation phenomenon, designs of super‐oscillatory lenses for sub‐diffraction focusing, super‐resolution imaging by optical super‐oscillation method, and applications in other domains. The shortcoming and prospective advancements of optical super‐oscillation technology are also discussed here. It is expected that this review can provide valuable insights for researchers committed to developing optical super‐oscillation technology in various fields.

show abstract

High‐Fidelity Far‐Field Microscopy at λ/8 Resolution

Cited by 7 publications

References 48 publications

Resolution-enhanced imaging for endoscopy using diffractive optics

Resolution-enhanced imaging for endoscopy using diffractive optics

Multiwavelength Achromatic Metalens in Visible by Inverse Design

Optical Super‐Oscillation Enables Sub‐Diffraction Focusing and Super‐Resolution Imaging in the Far‐Field

Contact Info

Product

Resources

About