High Frequencies of TNC and COL5A1 Genotypes Associated With Low Risk for Superficial Digital Flexor Tendinopathy in Greek Indigenous Horse Breeds Compared With Warmblood Horses

Giantsis, Ioannis A.; Diakakis, N.; Avdi, M.

doi:10.1016/j.jevs.2020.103173

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…A special type of over loading model is the spontaneous model, which involves anatomical differences. Horses and dogs can spontaneously develop tendinopathy [ 182 , 183 ].…”

Section: Animal Models Corresponding To Mechanical Loadmentioning

confidence: 99%

Animal model for tendinopathy

Luo

Wang

Tang

et al. 2023

Journal of Orthopaedic Translation

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“…A special type of over loading model is the spontaneous model, which involves anatomical differences. Horses and dogs can spontaneously develop tendinopathy [ 182 , 183 ].…”

Section: Animal Models Corresponding To Mechanical Loadmentioning

confidence: 99%

Animal model for tendinopathy

Luo

Wang

Tang

et al. 2023

Journal of Orthopaedic Translation

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“…Main documented characteristics of the studied horse populations include exceptional resilience to draught and heat, tolerance to poor nutrition, with physical and behavioral adaptations to fit the challenging mountainous ground and local conditions (from strong feet and small, hard hoofs to alert but self-composed temperament). They also exhibit low susceptibility to parasites, disease and physical injury, compared to other horses on the same environment (Giantsis et al, 2020;Kostaras et al, 2021). The oldest, traditional type has remarkably small body size and has been able to survive for long periods of time without human intervention in mountainous regions, forming feral populations (Papaioannou and Kostaras, 2006).…”

Section: Introductionmentioning

confidence: 99%

Genetic Variability of Small Horse Populations from Greek Islands

KATSOULAKOU

Papachristou

Kostaras

et al. 2023

Black Sea Journal of Agriculture

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In this study, we analyzed microsatellite variation in DNA obtained from hair samples collected from 46 local Greek horse populations originating from the islands of Skyros (Skyros Small Horse; n=9), Rhodes (Rodos Small Horse; n=6), Lesvos (with the traditional miniature Midili Small Horse (n=2) and the larger Lesvos Gaiter (n=22)) and Crete (Messara) (n=7). We used 15 autosomal microsatellite markers (VHL20, HTG4, AHT4, HMS7, HTG6, AHT5, HMS6, ASB2, HTG10, HTG7, HMS3, HMS2, ASB17, ASB23 and LEX33) for the genetic characterization of the above populations and exploration of their genetic structure and diversity levels. A total of 120 alleles were detected across the 15 loci with a minimum of 4 alleles in HTG7 locus and a maximum of 13 alleles in ASB17 locus. Τhe total per population number of alleles was 42 (Skyros Small Horse), 20 (Rodos Small Horse), 71 (Lesvos Gaiter), 52 (Messara breed) and 21 (Midili Small Horse). The effective number of alleles (Ne) per locus ranged from 1.47±0.13 (Rodos Small Horse) to 4.67±0.31 (Lesvos Gaiter). The allelic richness (Ar) was between 1.50±0.12 (Rodos Small Horse) and 2.93±0.08 (Lesvos Gaiter) and the average Polymorphism Information Content (PIC) values varied from 0.200±0.035 (Rodos Small Horse) to 0.733±0.026 (Lesvos Gaiter). No significant deviations from H-W equilibrium were found except for three loci (ASB2, HTG10 and LEX33) in Messara and one locus (ASB23) in Lesvos Gaiter. Τhe inbreeding coefficient (Fis) ranged from -0.130 (Rodos Small Horse) to 0.042 (Lesvos Gaiter). The observed (Ho) and expected (He) multilocus heterozygosity mean estimations were highest in Lesvos Gaiter (0.764±0.027 and 0.783±0.024, respectively) and smallest in Rodos Small Horse (0.300±0.075 and 0.269±0.064, respectively). Across loci, the total genetic diversity HT was 0.741, the diversity among subpopulations HS was 0.621 and the multilocus genetic differentiation GST was 0.161, which was rather high. The population of Rodos Small Horse separated from the remaining horses as shown by factorial correspondence analysis, population assignment and metric multidimensional scaling diagrams. This study highlights the loss of genetic diversity in small isolated horse populations and the urgent need to take protective measures to preserve them.

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