Origin, demographics, inbreeding, phylogenetics, and phenogenetics of Karamaniko breed, a major common ancestor of the autochthonous Greek sheep

Giantsis, Ioannis A.; Antonopoulou, Danai; Dekolis, Nikolaos; Zaralis, Konstantinos; Avdi, M.

doi:10.1007/s11250-022-03081-2

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…One hundred and fifty (150) of them belonged to Chios breed, 150 of them to the Florina breed sheep and the remaining 150 animals belonged to the Karagouniko breed. All three breeds examined constitute indigenous Greek breeds, which although reared in several different locations in Greece, the majority of those farmed populations have been subjected to extensive genetic admixture with other breeds (Giantsis et al, 2022). On the other hand, there are only a few certified purebred populations, and therefore, the relatively low number of investigated animals can be attributed to the fact that animals were chosen to originate solely from certi- Each breed was divided in three groups of 50 ewes, which were all in anoestrous period, as demonstrated by the levels of progesterone measurements before the experiment, and at the same lactation period, as schematically presented in Figure 1.…”

Section: Experimental Design Breeds' Description and Reproduction Par...mentioning

confidence: 99%

Association of MTNR1A and GDF9 gene allelles with the reproductive performance, response to oestrus induction treatments and prolificacy, in improved and non‐improved local indigenous sheep breeds

Antonopoulou,

Giantsis,

Symeon

et al. 2023

Reprod Domestic Animals

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Sheep farming plays a crucial role for Mediterranean countries, wherefrom a plethora of dairy products is produced. Yet, numerous indigenous sheep breeds in temperate latitudes such as the Mediterranean present a serious drawback that milk production is impaired by the seasonality of reproduction. Towards the efforts for reduction of this phenomenon, the purpose of this study was to evaluate and compare different oestrus synchronization treatments, as well as to associate two genes alleles', namely the MTNR1A and the GDF9, with the response to those treatments. Three indigenous breeds were investigated (Florina, Chios and Karagouniko sheep) and inside each breed three different oestrus synchronization treatments were applied (A: intravaginal sponges, B: GNRH use and C: male effect). In group A, Florina ewes expressed oestrus at 90% in July and fecundity was 85%. Karagouniko and Chios ewes exhibited an oestrus expression of 100% with fecundity rates at 95% and 99%, respectively. In group B, Florina ewes expressed oestrus at 60% with fecundity at 57%, Karagouniko ewes expressed oestrus at 65% with fecundity at 54%, whereas Chios breed animals expressed oestrus at 87% with fecundity rate at 85%. In group C, 68% of the Florina breed expressed oestrus 20–25 days post ram induction, whereas this proportion was 84% and 94%, for Karagouniko and Chios breed, respectively. For the molecular analysis, partial segments of the two genes were sequenced and analysed, whereas alleles were scored based on the detected SNPs. All frequencies of the four detected SNPs in MTNR1A gene were statistically and significantly different in ewes that expressed oestrus in comparison with ewes that did not express oestrus in Florina and Karagouniko breeds concerning all treatments. Two SNP's were detected in GDF9 gene, G1 and FecG, from which, only the FecG mutation exhibited statistically significant difference in twins and triplets than in singles in Florina and Karagouniko breeds.

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Section: Experimental Design Breeds' Description and Reproduction Par...mentioning

confidence: 99%

Association of MTNR1A and GDF9 gene allelles with the reproductive performance, response to oestrus induction treatments and prolificacy, in improved and non‐improved local indigenous sheep breeds

Antonopoulou,

Giantsis,

Symeon

et al. 2023

Reprod Domestic Animals

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“…The Massese breed has an open brown colored fleece due to the presence of two coat color types (black and grey) mainly derived by combining the ASIP and MC1R mutations [9][10][11]. These genes control coat color variations in sheep, which is a trait of great importance in farm animals in terms of identification and attribution, which are valuable in genetic improvement and selective breeding programs [9,12].…”

Section: Introductionmentioning

confidence: 99%

Demography and Genealogical Analysis of Massese Sheep, a Native Breed of Tuscany

Giuliotti,

Benvenuti,

Preziuso

et al. 2024

Animals

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This study investigates the genealogical and demographic trends of the Massese sheep breed in Tuscany from 2001 to 2021. The Herd Book kept by the Italian Sheep and Goat Breeders Association (Asso.Na.Pa) provided the data. The descriptive statistics were analyzed using JMP software. The pedigree parameters of a total of 311,056 animals (whole population—WP) were analyzed using CFC, ENDOG, and Pedigree viewer software. A total of 24,586 animals born in the period 2007–2021 represented the Reference Population (RP), and 18,554 animals the Base Population (BP). The demographic results showed an inconsistent trend of offspring registration. This study showed a short period of productivity for both ewes and rams, with means of 1.47 and 19.2 registered newborn ewes and rams, respectively. The genealogical analysis revealed incomplete data, highlighting inaccurate assessments of the relationships among the animals, and inbreeding with large differences among provinces. The average inbreeding coefficient in the WP was 1.16%, and it was 2.26% in the RP. The total number of inbreds was 2790 in the WP, with an average FPED of 13.56%, and 2713 in the RP, with an average FPED of 12.82%. The use of pedigree data is a key and economical approach to calculating inbreeding and relationship coefficients. It is the primary step in genetic management, playing a crucial role in the preservation of a breed. The regular updating of genealogical data is the first step to ensuring the conservation of animal genetic resources, and this study is compromised by the lack of such updates.

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“…Often this trait has been artificially selected, as the value of natural-colored wool depends on the fiber quality and coat color of the animal (e.g., merino sheep, cashmere goat, alpaca) [2]. Additionally, selective breeding in farm animals has been traditionally based on morphological characters based on coat coloration [3]. However, natural selection for adaptation to environment also acts on coat color variation [4], e.g., black-coated animals attract heat more than others in harsh deserts, supporting resistance to high thermal differences [5].…”

Section: Introductionmentioning

confidence: 99%

“…Welldefined genes for influencing coat color are the agouti signaling protein (ASIP or Agouti), melanocyte-stimulating hormone receptor (MC1R), and proto-oncogene receptor tyrosine kinase (KIT) [11][12][13][14][15][16][17][18][19][20][21][22]. MC1R and ASIP affect the ratio of eumelanin and pheomelanin distribution in mammals and particularly in domesticated animals [1,3,17]. Eumelanin is responsible for black, brown, or grey and pheomelanin for red, yellow or cream color, respectively [23].…”

Section: Introductionmentioning

confidence: 99%

Identification of Candidate Genes for Pigmentation in Camels Using Genotyping-by-Sequencing

Sani

Harofte

Banabazi

et al. 2022

Animals

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The coat color of dromedary is usually uniform and varies from black to white, although dark- to light-brown colors are the most common phenotypes. This project was designed to gain knowledge on novel color-related variants using genotyping-by-sequencing (GBS). The association between the SNPs and coat color was tested using MLM (mixed linear models) with kinship matrix. Three GWAS models including white color vs. non-white color, black vs. non-black color, and light-brown vs. dark-brown color were performed. There were no distinct genetic clusters detected based on the color phenotypes. However, admixture occurred among all individuals of the four different coat color groups. We identified nine significant SNPs associated with white color after Bonferroni correction, located close to ANKRD26, GNB1, TSPYL4, TEKT5, DEXI, CIITA, TVP23B, CLEC16A, TMPRSS13, FXYD6, MPZL3, ANKRD26, HFM1, CDC7, TGFBR3, and HACE1 genes in neighboring flanking regions. The 13 significant SNPs associated with black color and the candidate genes were: CAPN7, CHRM4, CIITA, CLEC16A, COL4A4, COL6A6, CREB3L1, DEXI, DGKZ, DGKZ, EAF1, HDLBP, INPP5F, MCMBP, MDK, SEC23IP, SNAI1, TBX15, TEKT5, TMEM189, trpS, TSPYL4, TVP23B, and UBE2V1. The SNAI1 gene interacted with MCIR, ASIP and KIT genes. These genes play a key role in the melanin biosynthetic and pigmentation biological process and melanogenesis biological pathway. Further research using a larger sample size and pedigree data will allow confirmation of associated SNPs and the identified candidate genes.

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Origin, demographics, inbreeding, phylogenetics, and phenogenetics of Karamaniko breed, a major common ancestor of the autochthonous Greek sheep

Cited by 5 publications

References 41 publications

Association of MTNR1A and GDF9 gene allelles with the reproductive performance, response to oestrus induction treatments and prolificacy, in improved and non‐improved local indigenous sheep breeds

Association of MTNR1A and GDF9 gene allelles with the reproductive performance, response to oestrus induction treatments and prolificacy, in improved and non‐improved local indigenous sheep breeds

Demography and Genealogical Analysis of Massese Sheep, a Native Breed of Tuscany

Identification of Candidate Genes for Pigmentation in Camels Using Genotyping-by-Sequencing

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