2007
DOI: 10.1038/sj.npp.1301561
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High-Frequency Afferent Stimulation Induces Long-Term Potentiation of Field Potentials in the Ventral Tegmental Area

Abstract: Excitatory synapses on dopamine neurons in the VTA can undergo both long-term potentiation and depression. Additionally, druginduced plasticity has been found at VTA synapses, and is proposed to play a role in reward-related learning and addiction by modifying dopamine cell firing. LTP at these synapses is difficult to generate experimentally in that it requires an undisturbed intracellular milieu and is often small in magnitude. Here, we demonstrate the induction of LTP as a property of evoked field potential… Show more

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Cited by 30 publications
(27 citation statements)
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“…As we previously reported (Nugent et al , 2007; Nugent et al , 2008), GABAergic synapses on VTA DA neurons undergo LTP in response to patterned local electrical stimulation (LTP GABA , Figure 1a). LTP GABA appears to be expressed by an increase in presynaptically released GABA, as the paired pulse ratio and coefficient of variation change after induction (Nugent et al , 2007).…”
Section: Resultssupporting
confidence: 80%
“…As we previously reported (Nugent et al , 2007; Nugent et al , 2008), GABAergic synapses on VTA DA neurons undergo LTP in response to patterned local electrical stimulation (LTP GABA , Figure 1a). LTP GABA appears to be expressed by an increase in presynaptically released GABA, as the paired pulse ratio and coefficient of variation change after induction (Nugent et al , 2007).…”
Section: Resultssupporting
confidence: 80%
“…To ensure that PPARα modulation of DA neuronal firing was not restricted to a certain DA subpopulation within the VTA, the effects of both MK886 and WY14643 were also investigated using extracellular evoked field potential recordings in horizontal brain slices (23). Figure 6 (A) shows that MK886 (500 nM, 5 min) induced a significant change in both negative components of the field potential (i.e.…”
Section: Resultsmentioning
confidence: 99%
“…Recordings were made from horizontal slices superfused with artificial cerebrospinal fluid (ACSF, 37° C) saturated with 95% O 2 and 5% CO 2 containing (in mM): 126 NaCl, 1.6 KCl, 1.2 NaH 2 PO 4 , 1.2 MgCl 2 , 2.4 CaCl 2 , 18 NaHCO 3 , and 11 glucose. Evoked field potential recordings were as described previously (23) and Supplement 1.…”
Section: Methodsmentioning
confidence: 99%
“…Subsequently, LTP has been investigated in a variety of mammalian species utilizing in vitro approaches including rat (Douglas and Goddard, 1975), mouse (Nosten-Bertrand et al, 1996), guinea pig (Harris and Cotman, 1986), monkey (Urban et al, 1996), and human (Chen et al, 1996; Beck et al, 2000; Cordoba-Montoya et al, 2010). Since its initial demonstration in the hippocampus (Bliss and Gardner-Medwin, 1973; Bliss and Lomo, 1973; Douglas and Goddard, 1975), LTP has been observed in various brain regions throughout the mammalian CNS, including the amygdala (Clugnet and LeDoux, 1990; Rogan et al, 1997; Sigurdsson et al, 2007), cortex (Artola and Singer, 1987; Teyler, 1989; Jung et al, 1990; Tsumoto, 1990; Kirkwood et al, 1993; Fox, 2002), striatum (Calabresi et al, 1992; Charpier and Deniau, 1997; Lovinger, 2010), ventral tegmental area (Nugent et al, 2007, 2008), cerebellum (Salin et al, 1996; Lev-Ram et al, 2002), and nucleus accumbens (Pennartz et al, 1993; Kombian and Malenka, 1994; Schotanus and Chergui, 2008). LTP can be observed both in vitro as well as in vivo condition.…”
Section: Introductionmentioning
confidence: 99%