High-frequency electric-field trap for micron and submicron particles

Müller, Torsten; Gerardino, A.; Schnelle, Thomas; Shirley, Stephen G.; Fuhr, G.; Gasperis, Giovanni De; Leoni, R.; Bordoni, F.

doi:10.1007/bf02457344

Cited by 17 publications

(14 citation statements)

References 7 publications

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“…Collection of particles is rapid and begins immediately after the field is applied. This experiment was performed at the Humboldt University of Berlin and first appeared in Müller et al (1996); reproduced with permission. Figure 8.…”

Section: Resultsmentioning

confidence: 99%

“…This step downward in size was accelerated by improvements in technologies for electrode fabrication, principally the use of electron beam fabrication. This renewed interest in manipulation of sub-micron particles, and subsequent work by Fuhr and co-workers [Fuhr 1995;Müller et al 1996] and Green et al [1995Green et al [ , 1997 demonstrated that viruses of 100nm diameter could be manipulated using negative dielectrophoresis. It was also demonstrated that latex spheres of 14nm diameter could be trapped by either positive or negative dielectrophoresis, as demonstrated by Müller et al [1996] and reproduced here in figure 7.…”

Section: Concentration Of Colloids From Solutionmentioning

confidence: 99%

“…This renewed interest in manipulation of sub-micron particles, and subsequent work by Fuhr and co-workers [Fuhr 1995;Müller et al 1996] and Green et al [1995Green et al [ , 1997 demonstrated that viruses of 100nm diameter could be manipulated using negative dielectrophoresis. It was also demonstrated that latex spheres of 14nm diameter could be trapped by either positive or negative dielectrophoresis, as demonstrated by Müller et al [1996] and reproduced here in figure 7. Subsequent work by Hughes and co-workers demonstrated that by varying the frequency of the applied electric field, Herpes viruses can be trapped using either positive or negative electric fields [1998].…”

Section: Concentration Of Colloids From Solutionmentioning

confidence: 99%

See 2 more Smart Citations

AC electrokinetics: applications for nanotechnology

Hughes¹

2000

Nanotechnology

266

177

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The phenomena of dielectrophoresis and electrorotation, collectively referred to as AC electrokinetics, have been used for many years to study, manipulate and separate particles on the nanotechnology, that is the precise manipulation of particles on the nanometre scale. In this paper we present the principles of AC electrokinetics for particle manipulation, review the current state of AC Electrokinetic techniques for the manipulation of particles on the nanometre scale, and consider how these principles may be applied to nanotechnology.3

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Section: Resultsmentioning

confidence: 99%

Section: Concentration Of Colloids From Solutionmentioning

confidence: 99%

Section: Concentration Of Colloids From Solutionmentioning

confidence: 99%

See 1 more Smart Citation

AC electrokinetics: applications for nanotechnology

Hughes¹

2000

Nanotechnology

266

177

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“…In order to manipulate biological particles, consequently, various dielectrophoresis-based techniques, including DEP trapping, DEP field-flow fractionation (DEP-FFF), traveling wave DEP (TwDEP) force and DEP barrier, are performed within a micro fluid channel [13][14][15][16][17][18][19][20][21]. DEP trapping techniques are mainly used to isolate particles within a still fluid utilizing p-DEP force [22][23][24][25]. The TwDEP force, DEP-FFF and DEP barrier techniques are realized via angled or vertical electrode pairs, and they are generally implemented with n-DEP force within the micro channel with fluidic flow [26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

The potential of a dielectrophoresis activated cell sorter (DACS) as a next generation cell sorter

Lee

Hwang

Kim

2016

Micro and Nano Syst Lett

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Originally introduced by H. A. Pohl in 1951, dielectrophoretic (DEP) force has been used as a striking tool for biological particle manipulation (or separation) for the last few decades. In particular, dielectrophoresis activated cell sorters (DACSes) have been developed for applications in various biomedical fields. These applications include cell replacement therapy, drug screening and medical diagnostics. Since a DACS does not require a specific bio-marker, it is able to function as a biological particle sorting tool with numerous configurations for various cells [e.g. red blood cells (RBCs), white blood cells (WBCs), circulating tumor cells, leukemia cells, breast cancer cells, bacterial cells, yeast cells and sperm cells]. This article explores current DACS capabilities worldwide, and it also looks at recent developments intended to overcome particular limitations. First, the basic theories are reviewed. Then, representative DACSes based on DEP trapping, traveling wave DEP systems, DEP field-flow fractionation and DEP barriers are introduced, and the strong and weak points of each DACS are discussed. Finally, for the purposes of commercialization, prerequisites regarding throughput, efficiency and recovery rates are discussed in detail through comparisons with commercial cell sorters (e.g. fluorescent activated and magnetic activated cell sorters).

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“…Microelectronic fabrication methods have been used to manufacture microelectrode arrays able to produce strong electric fields from low potentials over a wide range of frequencies. These have been successfully used for the dielectrophoretic manipulation of a variety of sub-micrometre particles, for example viruses, DNA and latex spheres [21][22][23][24][25][26][27][28]. The dielectric properties of sub-micrometre particles have been measured and characterized [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Ac electrokinetics: a survey of sub-micrometre particle dynamics

Green

Ramos

Morgan

2000

J. Phys. D: Appl. Phys.

210

160

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Abstract. Particles suspended in fluid exhibit motion when subjected to ac electric fields. The applied field results in forces on both the particles and the fluid, the study of which is referred to as ac electrokinetics. The ac electrokinetic techniques can be used for the controlled manipulation and characterization of particles, and the separation of mixtures. For sub-micrometre particles, Brownian motion is important and strong electric fields are required to overcome these effects. Planar micro-electrode arrays, fabricated using semiconductor manufacturing processes, can generate electric fields of the required strength from low potentials over a wide range of frequencies. This paper reviews and discusses sub-micrometre particle dynamics under the influence of dielectrophoretic and electrohydrodynamic forces. New experimental observations of the movement of sub-micrometre particles are also presented.

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High-frequency electric-field trap for micron and submicron particles

Cited by 17 publications

References 7 publications

AC electrokinetics: applications for nanotechnology

AC electrokinetics: applications for nanotechnology

The potential of a dielectrophoresis activated cell sorter (DACS) as a next generation cell sorter

Ac electrokinetics: a survey of sub-micrometre particle dynamics

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