High‐frequency ultrasonography but not 930‐nm optical coherence tomography reliably evaluates melanoma thickness
            <i>in vivo</i>
            : a prospective validation study

Meyer, Nicolas; Lauwers‐Cancès, Valérie; Lourari, S.; Laurent, J.; Konstantinou, M.P.; Lagarde, Jean‐Michel; Krief, B; Batatia, Hadj; Lamant, Laurence; Paul, C.

doi:10.1111/bjd.13129

Cited by 45 publications

(45 citation statements)

References 37 publications

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“…Therefore, Wortsman et al recommend that a physician a dermatologist or a radiologist-should be the person to perform ultrasonic examination [25]. The differences between mT measurements by two experienced dermatologists were found to be irrelevant in our study as well as in studies by other researchers [13,14]. In addition, we found non-significant differences between mT and aT measurements regarding the analyzed MST.…”

Section: Discussioncontrasting

confidence: 53%

“…Compared to high frequency US, optical coherence tomography has a lower accuracy in predicting mT [14]. Therefore, high frequency US is still an advanced tool for the estimation of CM thickness in vivo in cases of tumours of around 1 mm and thicker.…”

Section: Discussionmentioning

confidence: 99%

“…The review of Jasaitiene et al [7] and the recent studies [3,5,8,[9][10][11][12][13][14][15][16] showed a good correlation between pT and manually (mT) measured US thickness of MST using a 20-100 MHz transducer (Table 1). An overestimation of mT resulting from the impossibility of differentiating lymphocytic infiltrate or underlying melanocytic nevus cells from CM tissue has been reported in most studies [3,5,[9][10][11].…”

Section: Introductionmentioning

confidence: 86%

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Verification of new method for automatic thickness measurement of melanocytic skin tumours by high frequency ultrasound

Linkevičiūtė¹,

Raišutis²,

Sakalauskienė³

et al. 2018

J. vibroeng.

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Histological thickness of cutaneous melanoma (CM), known as the Breslow index (pT), represents the most important prognostic factor. The objective of this study is to evaluate the reliability of automatic algorithm based on B-scan image processing of 22 MHz ultrasound (US) for measuring the thickness of CM and melanocytic nevi (MN). The thickness of CM ( = 54) and MN ( = 91) has been measured manually (mT) and automatically (aT) using an algorithm based on B-scan image processing of 22 MHz US. All melanocytic skin tumours (MST) were surgically excised and their histological thicknesses (pT) according to Breslow were evaluated. The investigated parameters were expressed as medians with interquartile range (IQR) because of their asymmetric distribution, Spearman's correlation coefficient was determined as well. An agreement between values of mT/aT and mT/pT was evaluated by using the Bland-Altman plots. We found a good agreement of aT and mT with the moderate bias of 0.08 mm and relatively small range (95 % CI -0.01 to 0.18) in CM, accordingly 0.03 mm (95 % CI 0.00 to 0.07 mm) regarding MN. The medians of mT/pT in cases of CM and MN were 0.96 mm (IQR: 0.65-1.52) / 0.97 (IQR: 0.66-1.62) and 0.51 mm (IQR: 0.37-0.67) / 0.69 mm (IQR: 0.46-1.01) respectively. The parameters of the thickness correlated better in CM ( = 0.86) than in MN ( = 0.64) cases. The difference between manual (mT) and automatic (aT) measurements while evaluating the thickness of MST was non-significant. Therefore, automatic algorithm based on B-scan image processing of 22 MHz US is a reliable tool for measuring the thickness of MST by less experienced operators.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

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Verification of new method for automatic thickness measurement of melanocytic skin tumours by high frequency ultrasound

Linkevičiūtė¹,

Raišutis²,

Sakalauskienė³

et al. 2018

J. vibroeng.

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“…63 On the other hand, the wavelength of the OCTdevice influences the penetration depth, and studies have shown that high frequency ultrasound is superior to OCT-scans at 930 nm in determining tumor thickness. 64 A recent study has shown OCT at 1300 nm to be slightly more accurate in assessing tumor thickness, though both technologies tend to overestimate thin tumors (<0.2 mm) and underestimate thick tumors (>0.7 mm) compared to histology. 65 In a descriptive study using HD-OCT in pigmented lesions, melanomas have, compared to benign lesions, a higher frequency of fusion of rete ridge, pagetoid cells, and junctional and/or dermal nests with atypical cells.…”

Section: Nonmelanoma Skin Cancermentioning

confidence: 99%

Advances in optical coherence tomography in dermatology—a review

2018

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Optical coherence tomography (OCT) was introduced as an imaging system, but like ultrasonography, other measures, such as blood perfusion and polarization of light, have enabled the technology to approach clinical utility. This review aims at providing an overview of the advances in clinical research based on the improving technical aspects. OCT provides cross-sectional and en face images down to skin depths of 0.4 to 2.00 mm with optical resolution of 3 to 15 μm. Dynamic optical coherence tomography (D-OCT) enables the visualization of cutaneous microvasculature via detection of rapid changes in the interferometric signal of blood flow. Nonmelanoma skin cancer (NMSC) is the most comprehensively investigated topic, resulting in improved descriptions of morphological features and diagnostic criteria. A refined scoring system for diagnosing NMSC, taking findings from conventional and D-OCT into account, is warranted. OCT diagnosis of melanoma is hampered by the resolution and the optical properties of melanin. D-OCT may be of value in diseases characterized with dynamic changes in the vasculature of the skin and the addition of functional measures is strongly encouraged. In conclusion, OCT in dermatology is still an emerging technology that has great potential for improving further in the future.

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“…Thickness of the melanoma along with the number of mitoses and presence or absence of ulceration shows the greatest correlation with the degree of 5-year survival [2]. So far, individual studies have addressed the issue of pre-operative melanoma evaluation using ultrasonography, high-frequency ultrasonography (HFUS) and optical coherence tomography (OCT) [3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the clinical usefulness of high-frequency ultrasonography in pre-operative evaluation of cutaneous melanoma – a prospective study

Piłat¹,

Borzęcki²,

Jazienicki³

et al. 2020

pdia

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Introduction: There are many papers in the available literature on the pre-operative evaluation of malignant melanoma (MM) using a 20 MHz probe. In many Western European countries, this examination is standard in the diagnosis of such lesions in terms of the resection margin. However, few papers describe and compare the results of melanoma thickness measurements using 20 and 50 MHz frequency probes. Aim: The aim of the study was to evaluate the thickness of melanoma using 20 and 50 MHz probes. In addition, the obtained values were evaluated in comparison to the thickness values obtained in the histopathological examination. Material and methods: Melanoma malignum was confirmed histopathologically in 19 out of 72 patients. Then only those 19 patients were enrolled in the study. Results: A correlation was demonstrated between the thickness of the melanoma measured with the 20 and 50 MHz probes, expressed in mm, and the thickness obtained in the histopathological examination expressed in millimeters (Breslow's scale). It was 0.759 (p < 0.001) and 0.734 (p < 0.001), respectively. The average thickness of melanomas obtained in ultrasound examination was identical for both probes and was 0.74 mm. Conclusions: It seems that both types of probes can be used to assess melanoma thickness. The demonstrated correlation of high-frequency ultrasonography (HFUS) thickness with Breslow's scale indicates that the HFUS evaluation can be used in determination of melanoma resection margins as a repeatable, painless, non-invasive test.

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High‐frequency ultrasonography but not 930‐nm optical coherence tomography reliably evaluates melanoma thickness in vivo : a prospective validation study

Abstract: HFUS is a reliable and reproducible noninvasive method for assessing melanoma thickness. Routine use of HFUS may allow single-step excision of equivocal melanocytic lesions, with surgical margins determined by in vivo assessment of tumour thickness.

Cited by 45 publications

References 37 publications

Verification of new method for automatic thickness measurement of melanocytic skin tumours by high frequency ultrasound

Verification of new method for automatic thickness measurement of melanocytic skin tumours by high frequency ultrasound

Advances in optical coherence tomography in dermatology—a review

Evaluation of the clinical usefulness of high-frequency ultrasonography in pre-operative evaluation of cutaneous melanoma – a prospective study

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