High‐frequency ultrasound features in vulvar lichen sclerosus and correlation with histopathology

Zhou, Meng‐Yuan; Wang, Yukun; Zhu, Qingli; Liu, Jie

doi:10.1111/srt.13198

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…In the comparisons of both subjective improvement and clinical efficacy, the response of LSC to laser therapy was more favorable (21)(22)(23). Borghi et al found that patients with lichen sclerosus were often associated with other autoimmune disorders (24).…”

Section: Discussionmentioning

confidence: 99%

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Wei¹,

Li²,

Zhang³

et al. 2023

Ann Transl Med

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Background: A comparison of topical glucocorticoids with CO 2 fractional laser treatment was conducted to investigate the differences in the efficacy of non-neoplastic vulvar epithelial lesion treatments in different pathological types and to provide a scientific basis for the management of these disorders. This paper was to study the difference of curative effect of different pathological types of non-tumor vulvar epithelial lesions and provide scientific basis for the treatment of these diseases. Methods:From November 2016 to July 2018, 178 cases of vulvar lichen simplex chronicus (LSC) or lichen sclerosus were confirmed with vulvar biopsy at our institute. Finally, 160 patients were enrolled in this trial. The patients were divided into 2 groups: a group treated with topical hormone and a group treated with CO 2 lattice laser therapies. There were 80 cases in each group, including 40 with LSC and 40 with lichen sclerosus. Patients applied 1 gram of progesterone cream and betamethasone cream to the affected area in the morning and evening, respectively, once a day for 3 months. The efficacy was evaluated with the Patient Global Impression of Change (PGI-C) subjective symptom improvement scale and clinical efficacy evaluation scale. The formula was applied to calculate the curative effect index. Results:The PGI-C scores at 1, 3, and 6 months of treatment showed that the laser treatment group had remarkably superior outcomes to the glucocorticoid treatment group. The clinical efficacy score scale at 3and 6-month treatments indicated a significantly greater curative effect in the laser than in the glucocorticoid treatment (P=0.006 and P=0.002 respectively). In the glucocorticoid group, the clinical effects of different pathological subtypes were significantly different following the 1-and 3-month treatments. The efficacy of treatment for LSC was better than that for lichen sclerosus. Following the 3-and 6-month treatments, the clinical effect for LSC was better than that of lichen sclerosus (3 months: 95% vs. 75%; 6 months: and 95% vs. 70%).Conclusions: Ultrapulse CO 2 lattice laser was more effective than was glucocorticoid therapy in the treatment of vulvar epithelial non-tumor-like lesions.

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Section: Discussionmentioning

confidence: 99%

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Wei¹,

Li²,

Zhang³

et al. 2023

Ann Transl Med

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“…Inflammatory diseases represent a novel new frontier for the use of HRUS, which have been applied in the assessment and monitoring of psoriasis, dermatitis, vulvar lichen sclerosus and collagen vascular disease. 38,39 It can aid in diagnosis, quantification of disease severity, tracking of progression and assessment of response to treatment. 40 This capability provides critical data for personalized patient management and evaluation of therapeutic effectiveness.…”

Section: N Fl a M M Atory Dise Ase Smentioning

confidence: 99%

Seeing beyond skin deep: High‐resolution ultrasound in dermatology—A comprehensive review and future prospects

Liu,

Chew,

Honavar

et al. 2024

Acad Dermatol Venereol

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High‐resolution ultrasound (HRUS), operating at frequencies of 20–25 MHz, is a non‐invasive imaging tool that offers dermatologists the ability to visualize structures beneath the skin surface. The objective of this review is to present a comprehensive overview of HRUS applications, emphasising its utility in diagnosing, characterising and managing various dermatological conditions. We undertook a comprehensive literature review on the dermatological application of HRUS across Medline, Embase and Cochrane Library databases, while also incorporating our own clinical experience of over 16 years with the tool. In normal skin, the epidermis and dermis are hyperechoic, and the subcutaneous layer is hypoechoic. Basal cell carcinomas appear hypoechoic with irregular margins, while the presence of hyperechoic inclusion bodies suggests aggressive pathology. Squamous cell carcinomas pose challenges due to acoustic shadow artefacts from the thickened stratum corneum. Melanomas are homogenous hypoechoic lesions, with HRUS used to accurately predict Breslow thickness. HRUS provides dermatologists with a valuable adjunct to traditional clinical examination. Future advancement in image resolution and the standardisation of diagnostic parameters may further expand its utility.

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High-frequency ultrasound assessment of vulvar lichen sclerosus treated with photodynamic therapy

Wang

Hao

Liu

2023

Photodiagnosis and Photodynamic Therapy

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High‐frequency ultrasound features in vulvar lichen sclerosus and correlation with histopathology

Cited by 5 publications

References 18 publications

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Seeing beyond skin deep: High‐resolution ultrasound in dermatology—A comprehensive review and future prospects

High-frequency ultrasound assessment of vulvar lichen sclerosus treated with photodynamic therapy

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