High-frequency ultrasound of skin involvement in systemic sclerosis reflects oedema, extension and severity in early disease

Hesselstrand, Roger; Scheja, Agneta; Wildt, Marie; Åkesson, Anita

doi:10.1093/rheumatology/kem307

Cited by 117 publications

(134 citation statements)

References 14 publications

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“…The authors concluded that HFUS may allow for the identification of patients with diffuse skin involvement very early in the disease process, and in assessing the severity of the skin disease. 51 Ultrasound has also been used to interpret treatment outcome in inflammatory dermatoses. In skin disorders such as morphea and sclerosis, response to treatment is commonly assessed using a scoring system based on palpation.…”

Section: Inflammatory Diseases/infectious Diseases/ Benign Neoplasmsmentioning

confidence: 99%

Ultrasound in dermatology: Principles and applications

Kleinerman

Whang

Bard³

et al. 2012

Journal of the American Academy of Dermatology

184

175

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Section: Inflammatory Diseases/infectious Diseases/ Benign Neoplasmsmentioning

confidence: 99%

Ultrasound in dermatology: Principles and applications

Kleinerman

Whang

Bard³

et al. 2012

Journal of the American Academy of Dermatology

184

175

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“…Also problematic is the need for investigator training, varying degrees of examiner's experience, and uncertainty about the sensitivity of the scores over time [13][14][15][16][17]. Several objective methods for assessment of scleroderma have been proposed, including ultrasound, X-ray, MRI, indentation, and durometry [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of scleroderma by surface wave technique

Zhang¹,

Osborn²,

Pittelkow³

et al. 2011

Medical Engineering & Physics

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“…The cutaneous involvement varies from limited to diffuse skin fibrosis 1 . High-frequency and high-resolution ultrasound probes offer the opportunity to evaluate not only skin thickness but also its echogenicity 2 . The mechanical properties of tissue depend on the constituent macromolecules, such as fat and collagen, and on the structural organization.…”

mentioning

confidence: 99%

Ultrasound Elastography Assessment of Skin Involvement in Systemic Sclerosis: Lights and Shadows

Iagnocco¹,

Kaloudi²,

Perella³

et al. 2010

J Rheumatol

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Objective. To assess skin elasticity in systemic sclerosis (SSc) by using a new imaging modality, ultrasound elastography (UE). Methods. Our study included 18 consecutive patients with SSc and 15 healthy controls. Modified Rodnan skin score, physical examination, and assessment of organ involvement were performed. UE was carried out on the middle forearm and on the fingers of the dominant arm. The echo signals recorded in real time during freehand operations of probe compression and relaxation produced images representing tissue elasticity, consisting of translucent colored bands superimposed on the B-mode ultrasonographic images. The color scale varied within a large band spectrum from red, indicative of soft and highly elastic tissue, to blue, which denoted hard and barely elastic tissue. Results. On the forearm of all patients, UE showed a homogeneous blue area corresponding to the dermis visualized in a B-mode ultrasonographic image; in controls, a blue pattern was never detected and a predominance of green with sporadic areas of pale blue was observed. At sequential evaluations, UE of fingers produced inconstant and changeable colored areas. Conclusion. The imaging pattern observed in the forearm of patients with SSc may represent the reduction of strain in the dermis clue to loss of elasticity. The variable pattern obtained by finger evaluation demonstrated that UE can assess skin involvement in SSc only in those areas where the dermis is known to be thicker and where the bone hyperreflection is minimal. Further studies are needed to confirm our results and determine the validity of this new imaging modality. (First Release June 15 2010; J Rheumatol 2010;37: 1688-91: doi:10.3899/jrheum.090974

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High-frequency ultrasound of skin involvement in systemic sclerosis reflects oedema, extension and severity in early disease

Cited by 117 publications

References 14 publications

Ultrasound in dermatology: Principles and applications

Ultrasound in dermatology: Principles and applications

Quantitative assessment of scleroderma by surface wave technique

Ultrasound Elastography Assessment of Skin Involvement in Systemic Sclerosis: Lights and Shadows

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