Virtual substrates based on thin Ge layers on Si by direct deposition have achieved high quality recently. Their application to high efficiency III-V solar cells is analyzed in this work. Replacing traditional Ge substrates with Ge/Si virtual substrates in standard lattice-matched and upright metamorphic GaInP/Ga(In)As/Ge solar cells is feasible according to our calculations using realistic parameters of state-of-the-art Ge solar cells but with thin bases (< 5µm). The first experimental steps are tackled by implementing Ge single-junction and full GaInP/Ga(In)As/Ge triple-junction solar cells on medium quality Ge/Si virtual substrates with 5µm thick Ge layers. The resultsshow that the photocurrent in the Ge bottom cell is barely enough to achieve current matching with the upper subcells, but the overall performance is poor due to low voltages in the junctions. Moreover, observed cracks in the triple-junction structure point to the need to reduce the thickness of the Ge + III-V structure or using other advanced approaches to mitigate the thermal expansion coefficient mismatch effects, such as using embedded porous silicon. Next experimental work will pursue this objective and use more advanced Ge/Si virtual substrates available with lower threading dislocation densities and different Ge thicknesses.Index Terms -III-V multijunction solar cell, germanium buffer, low cost substrate, virtual substrate. This is an accepted proceedings paper presented at IEEE PVSC 2019, in press.