High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia

Park, Jean R.; Li, Feng; Oza, Veeral; Sklaw, Brett; Cronley, Kevin M.; Wellner, Michael; Swanson, Benjamin J.; Krishna, Somashekar G.

doi:10.1016/s1499-3872(16)60186-8

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…The ordinality of the correlations supported our abovementioned conclusion. Several studies have reported that pancreatic parenchymal EUS findings correlate with fibrosis 14 – 16 and that chronic inflammation, such as CP, is closely associated with increased microscopic precancerous lesions in humans and mice 21 – 23 . However, the literature on the direct relationship between pancreatic parenchymal EUS findings and microscopic precancerous lesions is limited.…”

Section: Discussionmentioning

confidence: 99%

Benefits of pancreatic parenchymal endoscopic ultrasonography in predicting microscopic precancerous lesions of pancreatic cancer

Yamakawa¹,

Inomata²,

Masuda³

et al. 2023

Sci Rep

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Pancreatic cancer primarily arises from microscopic precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and acinar-to-ductal metaplasia (ADM). However, no established method exists for predicting pancreatic precancerous conditions. Endoscopic ultrasonography (EUS) can detect changes in pancreatic parenchymal histology, including fibrosis. This study aimed to elucidate the relationship between pancreatic parenchymal EUS findings and microscopic precancerous lesions. We retrospectively analyzed 114 patients with pancreatobiliary tumors resected between 2010 and 2020 and evaluated the association between pancreatic parenchymal EUS findings and the number of PanIN, ADM, and pancreatic duct gland (PDG). Of the 114 patients, 33 (29.0%), 55 (48.2%), and 26 (22.8%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. Multivariate analyses revealed that abnormal EUS findings were significantly associated with the frequency of PanIN (hyperechoic foci/stranding without lobularity: OR [95% CI] = 2.7 [1.0–7.3], with lobularity: 6.5 [1.9–22.5], Ptrend = 0.01) and ADM (hyperechoic foci/stranding without lobularity: 3.1 [1.1–8.2], with lobularity: 9.7 [2.6–36.3], Ptrend = 0.003) but not with PDG (hyperechoic foci/stranding without lobularity: 2.2 [0.8–5.8], with lobularity: 3.2 [1.0–10.2], Ptrend = 0.12). We observed a trend toward a significantly higher number of precancerous lesions in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. Pancreatic parenchymal EUS findings were associated with the increased frequency of PanIN and ADM. Lobularity may help predict the increased number of precancerous lesions.

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Section: Discussionmentioning

confidence: 99%

Benefits of pancreatic parenchymal endoscopic ultrasonography in predicting microscopic precancerous lesions of pancreatic cancer

Yamakawa¹,

Inomata²,

Masuda³

et al. 2023

Sci Rep

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“…In our collective of patients, chronic pancreatitis and PAC contributed 2.9 and 56.7% of patients respectively, remaining more than 40% of patients with diseases where the pancreas remnant could be softer ( Table 1 ). 9 , 53 – 55…”

Section: Discussionmentioning

confidence: 99%

Impact factors for perioperative morbidity and mortality and repercussion of perioperative morbidity and long-term survival in pancreatic head resection

Potrč

Ivanecz

Pivec

et al. 2017

Radiology and Oncology

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BackgroundThe focus of the present study was to reveal any impact factors for perioperative morbidity and mortality as well as repercussion of perioperative morbidity on long-term survival in pancreatic head resection.Patients and methodsIn a retrospective study, clinic-pathological factors of 240 patients after pancreatic head (PD) or total resection were analyzed for correlations with morbidity, 30- and 90-day mortality, and long-term survival. According to Clavien–Dindo classification, all complications with grade II and more were defined as overall complications (OAC). OAC, all surgical (ASC), general (AGC) and some specific types of complications like leaks from the pancreatoenteric anastomosis (PEA) or pancreatic fistula (PF, type A, B and C), leaks from other anastomoses (OL), bleeding (BC) and abscesses (AA) were studied for correlation with clinic-pathological factors.ResultsIn the 9-year period, altogether 240 patients had pancreatic resection. The incidence of OAC was 37.1%, ASC 29.2% and AGC 15.8%. ASC presented themselves as PL, OL, BC and AA in 19% (of 208 PD), 5.8%, 5.8%, and 2.5% respectively. Age, ASA score, amylase on drains, and pancreatic fistulas B and C correlated significantly with different types of complications. Overall 30- and 90-day mortalities were 5 and 7.9% and decreased to 3.5 and 5% in P2.ConclusionsHigh amylase on drains and higher mean age were independent indicators of morbidity, whereas PL and BC revealed as independent predictor for 30-day mortality, and physical status, OAC and PF C for 90-day mortality.

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Single-cell omics: a new perspective for early detection of pancreatic cancer?

Wang

Sabanovic

Awada

et al. 2023

European Journal of Cancer

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High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia

Cited by 6 publications

References 22 publications

Benefits of pancreatic parenchymal endoscopic ultrasonography in predicting microscopic precancerous lesions of pancreatic cancer

Benefits of pancreatic parenchymal endoscopic ultrasonography in predicting microscopic precancerous lesions of pancreatic cancer

Impact factors for perioperative morbidity and mortality and repercussion of perioperative morbidity and long-term survival in pancreatic head resection

Single-cell omics: a new perspective for early detection of pancreatic cancer?

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