High-grade spheno-orbital meningioma in patients with systemic lupus erythematosus: Two case reports and literature review

Abdulqader, Sarah Bin; Almujaiwel, Nasser; AlShakweer, Wafa; Alzhrani, Gmaan

doi:10.25259/sni_583_2020

Cited by 3 publications

(4 citation statements)

References 57 publications

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“…We showed that SLE patients had twice the risk of developing cancer of the meninges and spine, but not the brain (cerebrum/cerebellum). The lack of association between SLE and brain cancer confirms existing data, 2 but there are some data to suggest that SLE patients are susceptible to developing meningioma 68 . We did not find an increased odds of viral infections of the central nervous system at time zero.…”

Section: Discussionsupporting

confidence: 87%

“…The lack of association between SLE and brain cancer confirms existing data, 2 but there are some data to suggest that SLE patients are susceptible to developing meningioma. 68 We did not find an increased odds of viral infections of the central nervous system at time zero. Although, it is unclear what underlies the potential mechanism between SLE and these rare cancers, future studies could investigate the role of neuropsychiatric disease activity and cancer development of the nervous system.…”

Section: Ta B L E 2 (Continued)contrasting

confidence: 55%

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Cancer development in patients hospitalized with systemic lupus erythematosus: A population‐level data linkage study

et al. 2023

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Aim To explore the association between systemic lupus erythematosus (SLE) with the risk of cancer development and subsequent 5‐year mortality in Western Australia (WA). Methods Population‐level, data linkage study of SLE patients (n = 2111) and general population comparators (n = 21 110) hospitalized between 1980 and 2014. SLE patients (identified by ICD‐9‐CM: 695.4, 710.0, and ICD‐10‐AM: L93.0, M32.0) were nearest matched (10:1) for age, sex, Aboriginality, and temporality. Follow up was from time zero (index SLE hospitalization) to cancer development, death or 31 December 2014. We assessed the risk of cancer development and subsequent 5‐year mortality between SLE patients and comparators with univariate and multivariate‐adjusted Cox proportional hazards regression models. Results SLE patients had similar multivariate‐adjusted risk (adjusted hazard ratio [aHR] 1.03, 95% confidence interval [CI] 0.93–1.15; p = .583) of cancer development. Cancer development risk was higher in SLE patients <40 years old (aHR 1.58, 95% CI 1.29–1.94; p < .001), and from 1980 to 1999 (aHR 1.16, 95% CI 1.02–1.31; p < .001). SLE patients had higher risk of developing cancer of the oropharynx (aHR 2.13, 95% CI 1.30–3.50), vulvo‐vagina (aHR 3.22, 95% CI 1.34–7.75), skin (aHR 1.20, 95% CI 1.01–1.43), musculoskeletal tissues (aHR 2.26, 95% CI 1.16–4.40), and hematological tissues (aHR 1.78 95% CI 1.25–2.53), all p < .05. After cancer development, SLE patients had increased risk of 5‐year mortality (aHR 1.31, 95% CI 1.06–1.61); highest in patients <50 years old (aHR 2.03, 95% CI 1.03–4.00), and in those with reproductive system and skin cancers. Conclusions Hospitalized SLE patients had increased risk of multiple cancer sub‐types. Following cancer development, SLE patients had increased risk of 5‐year mortality. There is scope to improve cancer prevention and surveillance in SLE patients. Trial registration Not applicable. This low‐risk risk study used de‐identified administrative linked health data.

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Section: Discussionsupporting

confidence: 87%

Section: Ta B L E 2 (Continued)contrasting

confidence: 55%

Cancer development in patients hospitalized with systemic lupus erythematosus: A population‐level data linkage study

et al. 2023

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“…Cell cycle process has been proved that it has an important role in the development of meningioma 58 . And, some reports showed that systemic lupus erythematosus and meningioma happened in a patient 59,60 , which may reveal that progression of meningioma may involve in the immune process and reaction. Next, the GSEA analysis proved that and identified some immune related pathways including activating and supressing.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and Doxorubicin involved in malignant progression of meningioma

Huo

Song

Wang

et al. 2023

Sci Rep

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Meningioma was the most primary intracranial tumor, but the molecular characteristics and the treatment of malignant meningioma were still unclear. Nine malignant progression-related genes based prognostic signatures were identified by transcriptome analysis between benign meningioma and malignant meningioma. The external dataset GEO136661 and quantitative Real-time Polymerase Chain Reaction were used to verify the prognostic factors. has-miR-3605-5p, hsa-miR-664b-5p, PNRC2, BTBD8, EXTL2, SLFN13, DGKD, NSD2, and BVES were closed with malignant progression. Moreover, Doxorubicin was identified by Connectivity Map website with the differential malignant progression-related genes. CCK-8 assay, Edu assay, wound healing assay, and trans-well experiment were used to reveal that Doxorubicin could inhibit proliferation, migration and invasion of IOMM-Lee Cells.

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“…Spheno-orbital meningiomas are usually low grade (Grade I). High-grade meningiomas, such as Grades II and III, in the spheno-orbital region are usually rare [31]. The exact cause and mechanism of bone hyperostosis in spheno-orbital meningioma remain unclear and subjected to debate.…”

Section: Discussionmentioning

confidence: 99%

Correspondence of Meningioma Orbital Grading and Clinicopathological Features among Indonesian Patients

Janah

Rujito

Wahyono

2022

Open Access Maced J Med Sci

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BACKGROUND: Orbital meningiomas can cause visual disturbances, protrusion of the eyes, double vision, and optic nerve abnormalities that significantly decrease vision and eventually lead to blindness. To the best of our knowledge, data on the incidence and pathogenesis of orbital meningioma in Indonesia are non-existent. AIM: This study aimed to analyze the clinicopathological relationship with orbital meningioma grading. METHODS: It is a cross-sectional observational analysis on 44 orbital meningioma patients in Dr. Hasan Sadikin General Hospital and the National Eye Center, Cicendo Eye Hospital in 2017–2020. Chi-square analysis and logistic regression with statistical significance (p < 0.05) were engaged in the method. RESULTS: Orbital meningioma mostly occurred in women aged 30–44 years. Meningioma Grade I was dominated by meningothelial meningioma found in 14 (31.8%) patients, Grade II was atypical meningioma in 9 (20.9%) patients, and Grade III was anaplastic meningioma in 3 patients (6.8%). Clinical symptoms in the form of papillary atrophy (p = 0.046), visual acuity (p = 0.026), proptosis (p = 0.029), and hyperostosis (p = 0.024) were statistically significant and there was a significant difference between Grade I, Grade II, and Grade III using the Chi-square test. Logistic regression results showed that hyperostosis is significantly related to grading the orbital meningioma (p = 0.044) with an odds ratio of 0.206 (IK95% 0.04–0.955). CONCLUSION: Hyperostosis increases the grading of the orbital meningioma because it is related to the invasion of the tumor into the orbital bone and is a neoplastic process. The presence of hyperostosis which is more common in Grade III meningiomas can be used as one of the most important predictors of meningioma recurrence postoperatively. Nonetheless, our data add to the existing literature the potential points of anti-invasive adjuvant therapy attacks.

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High-grade spheno-orbital meningioma in patients with systemic lupus erythematosus: Two case reports and literature review

Cited by 3 publications

References 57 publications

Cancer development in patients hospitalized with systemic lupus erythematosus: A population‐level data linkage study

Cancer development in patients hospitalized with systemic lupus erythematosus: A population‐level data linkage study

Prognostic factors and Doxorubicin involved in malignant progression of meningioma

Correspondence of Meningioma Orbital Grading and Clinicopathological Features among Indonesian Patients

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