High Incidence of Hepatitis C Virus Infection in Hemodialysis Patients in Taiwan

Lin, Deng‐Yn; Lin, Hwai Jeng; Huang, Chun-Hsien; Liaw, Yun–Fan

doi:10.1016/s0272-6386(12)80748-7

Cited by 41 publications

(29 citation statements)

References 11 publications

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“…The risk of HCV was multiplied by more than three times when this number exceeded three red blood cells. Similar results were reported in several studies [25][26][27][28][29][30]. However, it was noted as in several studies, only 26 of the 56 HCV + patients were never transfused, highlighting the involvement of other factors in the prevalence of HCV.…”

Section: Factors Prevalence Of Hepatitis C Virus In Hemodialysissupporting

confidence: 90%

“…This observation was confirmed by numerous studies, particularly in Brazil, where the prevalence of hepatitis C virus was 37.8% before the introduction of screening for HCV in red blood cells in 1993 with a risk sixfold [25][26][27][28]. After that date, the prevalence of HCV in this population decreased to 16.5% in 2002 [29]. In Morocco, the detection of HCV in blood products was introduced in 1994.…”

Section: Factors Prevalence Of Hepatitis C Virus In Hemodialysismentioning

confidence: 71%

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Hepatitis C Viral Prevalence and Seroconversion in Moroccan Hemodialysis Units: Eight Year Follow Up

Omar¹

2013

J Med Diagn Meth

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Introduction: The prevalence of Hepatitis C Virus (HCV) in chronic hemodialysis patients is eight times higher than among the general population. It is estimated between 3 and 65.8% in different studies and countries and is a contributor to mortality in this population. The aim of this study is to define the factors influencing prevalence and seroconversion of HCV in an ambispective study including 15 centers and 163 hemodialysis patients.Methods: Multicenter ambispective Study including 167 patients treated in 15 dialysis centers in 4 cities and over a period of 8 years. In 2002, all patients underwent determination of liver enzymes, a serological survey and qualitative research of HCV RNA by polymerase chain reaction followed by a genotyping for patients confirmed positive by the method LIPA. Serological status and movement of patients between centers was followed for 8 years. In 2010, the survivors benefit serology of viral hepatitis B and C (4 th generation ELISA) with research of viral RNA by PCR. Results:The mean age of patients at baseline was 51 years of which 11% were diabetic with a mean of 55 months on hemodialysis. The prevalence of HCV was 33.4% with significantly higher ALT in positive patients and genotype 1b was most frequent (54%). Statistical analysis found that the factors of prevalence are: time on hemodialysis, number of units visited (2.2 vs. 3, p<0.001), number of red blood cells transfused (1.5 vs. 2.5, p=0.009) and area of the unit. After 8 years, overall survival was 58.2% with a prevalence of HCV at 26.2%. During follow-up, 7 seroconversion were objectified and the only factor found is the number of centers visited.Conclusions: These data suggest that nosocomial transmission plays an important role hence the importance of strict implementation of the recommendations of prevention against the transmission of HCV in particular the training of personnel and control the transfer of patients between centers.Keywords: Hemodialysis; Hepatitis C virus; Prevalence; Seroconversion Introduction:Hepatitis C virus (HCV) infection represents a big public health challenge in this millennium and the World Health Organization estimates that, until 1998, 170 million people carried the HCV worldwide and in recent years 200 million or 3% of the world population is infected with this virus [1]. Low prevalence is reported in Europe and North America, while it's high in the Far East and Africa where the prevalence exceeds 10% in Egypt. In Morocco, a recent study showing that among the 8326 samples tested by third generation ELISA, 161 samples were positive, so a prevalence of 1.93% [2].In dialysis the problem is much broader, with a prevalence that can reach 80% and an incidence of more than 9% per year [3][4][5][6]. To this is added a high mortality in hemodialysis patients infected with HCV according to many authors [7][8][9][10]. In Morocco it is estimated that the prevalence of hepatitis C virus in dialysis is 32% according to the National Register "MAGREDIAL [4]. But this rate varies widely amon...

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Section: Factors Prevalence Of Hepatitis C Virus In Hemodialysissupporting

confidence: 90%

Section: Factors Prevalence Of Hepatitis C Virus In Hemodialysismentioning

confidence: 71%

Hepatitis C Viral Prevalence and Seroconversion in Moroccan Hemodialysis Units: Eight Year Follow Up

Omar¹

2013

J Med Diagn Meth

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“…Com a descoberta do vírus da hepatite C (VHC) e sabendo ser sua transmissão parenteral preferencialmente, pacientes em unidades de diálise foram então considerados de alto risco para aquisição da doença 9 . Vários estudos demonstram valores bastantes variáveis da prevalência de anti-VHC em diferentes unidades de diálise de acordo com a região.…”

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Soroprevalência do vírus da hepatite C na população em diálise de Goiânia, GO

Naghettini

Daher²,

Martin³

et al. 1997

Rev. Soc. Bras. Med. Trop.

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Um estudo soroepidemiológico para anticorpo do vírus da hepatite C (anti-VHC) foi realizado na população em diálise de Goiânia ,com objetivo de avaliar a soroprevalência do vírus e sua associação com possíveis fatores de risco. Foram estudados 173 pacientes com idade variando de 1070 anos, 35,3% (61/173) apresentaram soropositividade pelo ELISA de segunda geração e 25% (44/173) pelo INNO-LIA.Uso de drogas, hábitos sexuais, número de transfusões e atividade de transaminases não apresentaram relação significativa com a soropositividade. A permanência no tratamento e o uso da hemodiálise apresentaram correlação positiva com o anti-VHC (p < 0,05).Os dados sugerem que a hepatite C tem alta prevalência nos pacientes em hemodiálise e que o tempo em tratamento é um fator de risco para adquirir a infecção.

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“…A incidência de soroconversão para anti-HCV em pacientes em terapia renal substitutiva no Brasil foi semelhante à encontrada na Alemanha 10 (ambos os países com 1,7 soroconversão por 100 pacientes/ano) e menor que as registradas em Taiwan 19 (14,6 soroconversões por 100 pacientes/ano), na Itália 20 (6,25 soroconversões 24 . A prevenção da exposição ao sangue ou a outros materiais biológicos é a principal medida para que não ocorra contaminação por patógenos de transmissão sanguínea nos serviços de saúde.…”

Section: Discussionunclassified

Incidência de hepatite viral C em pacientes em hemodiálise no Brasil entre 2000 e 2003

et al. 2016

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Resumo: O estudo visou estimar a incidência dos fatores associados à soroconversão para o anti-HCV em pacientes em hemodiálise no Sistema Único de Saúde (SUS). Trata-se de um estudo prospectivo, não concorrente, utilizando dados de pacientes identificados por relacionamento determinístico-probabilístico nos registros dos sistemas de informação do SUS. Foram incluídos 47.079 pacientes que iniciaram em hemodiálise no período de 1º de janeiro de 2000 a 31 de dezembro de 2003, acompanhados até a soroconversão ou o término do estudo em 2004. Nesta pesquisa, 3% dos pacientes em hemodiálise apresentaram soroconversão para anti-HCV (incidência de 1,7 soroconversão por 100 pacientes/ano). Maior risco de soroconversão para o anti-HCV foi associado com idade, glomerulonefrites, região de residência, anti-HIV positivo e efeito da unidade de diálise. A incidência observada de soroconversão para anti-HCV foi semelhante à registrada em alguns países desenvolvidos, destacando-se a evidência de transmissão entre os pacientes em hemodiálise.

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High Incidence of Hepatitis C Virus Infection in Hemodialysis Patients in Taiwan

Cited by 41 publications

References 11 publications

Hepatitis C Viral Prevalence and Seroconversion in Moroccan Hemodialysis Units: Eight Year Follow Up

Hepatitis C Viral Prevalence and Seroconversion in Moroccan Hemodialysis Units: Eight Year Follow Up

Soroprevalência do vírus da hepatite C na população em diálise de Goiânia, GO

Incidência de hepatite viral C em pacientes em hemodiálise no Brasil entre 2000 e 2003

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