High incidence of oncogenic HPV genotypes found in women from Southern Brazil

Abstract

Oncogenic HPV genotypes are strongly associated with premalignant and malignant cervical lesion. The purpose was to determine human papillomavirus (HPV) prevalence and genotypes, and to estimate cervical cancer risk factor associations. Cervical samples were obtained from 251 women seeking gynecological care at the Pelotas School of Medicine Clinic. This is a cross-sectional study. HPV-DNA was amplified by nested-PCR using MY09/11 and GP5/6 primers, and the sequencing was used for genotyping. Sociodemographic and behavioral risk factors were obtained by closed questionnaire, and its relationship to HPV infection prevalence were analyzed. Statistical analyses were performed using SPSS 16.0 software, and differences were considered significant at p < 0.05. As results, the prevalence of HPV infection was 29.9%. The most frequent genotype was HPV-16 (41.3%), followed by HPV-18 (17.3%), and HPV-33 (9.3%). Others nine HPV genotypes were also found. On this population, prevalence of oncogenic HPV genotypes was high, but does not seem to confer relationship with the risk factors investigated. Future investigations in larger populations are necessary, for the proposition of more appropriated monitoring strategies and treatment according to the Brazilian health service reality, as well as patients.

Prevalence Of Human Papillomavirus And Co-existent Sexually Transmitted Infections Among Female

“…It was evidenced in the research that among users of illicit drugs, 74.07% and 83.33% practice anal and oral sex respectively; 94.44% do not take contraceptives. However, we did not identify relation between contraceptive and higher risk for infection (ENTIAUSPE, et al, 2014).…”

Genotypes distribution of human papillomavirus in cervical samples of Ecuadorian women

“…Most of the samples collected by our Gynecology service came from Institutions different from ours with specific request of HPV genotyping analysis. This situation REV BRAS EPIDEMIOL JAN-MAR 2016; 19(1): 160-166 IS39 68 64 26 82 67 69 35 39 40 81 73 83 72 42 71 61 59 55 53 84 31 52 62 70 CP6108 45 51 58 6 54 56 66 18 11 33 The prevalence of HPV (43.58%) among the studied population resulted similar than reported in Colombia (44.30%) among HIV negative patients, but higher than values estimated among Brazilian (29.90%) and Peruvian women (34.49%) [13][14][15] .…”

Relationship between the risk factors for human papillomavirus infection and lower genital tract precursor lesion and cancer development in female transplant recipients

“…Upon comparing this prevalence with the 17 literature articles in the general population, there was a statistically significant difference between the value found in the study (54.5%) with all results (13.7%‐40.6%).…”