High Incidence of Several Malformations in the Early Human Embryos as Compared with Infants

Nishimura, Hideo; Takano, Kiichi; Tanimura, Takashi; Yasuda, Mineo; Uchida, Tetsuro

doi:10.1159/000240012

Cited by 56 publications

(15 citation statements)

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“…An appreciable number of anencephalics weighed less than 1,000g. These findings are in agreement with those of Stevenson, Dudgeon and McClure (1959) and Nishimura, Takano, Tanimura, Yasuda and Uchida (1966), who found the frequency of neural tube defects much higher among miscarried foetuses than in the newborn. There is some relationship between birth weight and the frequency of still birth ( Figure 2b); for neural tube defects of birth weight less than 3,000g.…”

Section: Epidemiological Characterisncssupporting

confidence: 93%

Major malformations of the central nervous system in Hungary.

Czeizel¹,

Révész²

1970

Journal of Epidemiology & Community Health

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Section: Epidemiological Characterisncssupporting

confidence: 93%

Major malformations of the central nervous system in Hungary.

Czeizel¹,

Révész²

1970

Journal of Epidemiology & Community Health

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“…Secondly, symptoms produced in the mother by a congenitally abnormal fetus might result in a significant association between any drug used for the treatment of these symptoms and the congenital abnormality. Thirdly, in the early weeks of pregnancy the incidence of certain severe malformations in the embryo may be 10 or more times that seen in stillborn and liveborn infants (Nishimura et al, 1966). Most of these abnormal embryos must be aborted.…”

Section: Discussionmentioning

confidence: 99%

Associations between Drugs Administered during Pregnancy and Congenital Abnormalities of the Fetus

Nelson¹,

Forfar²

1971

BMJ

319

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SummaryIn a retrospective study to compare the drug consumption during pregnancy of mothers of infants with congenital abnormalities and of those without, over 97% of 1,369 mothers took prescribed drugs and 65% self-administered drugs. Significantly more mothers of infants with congenital abnormalities took aspirin, antacids, dextroamphetamine, phenobarbitone, sodium amytal, other barbiturates, cough medicines, iron, sulphonamides, and nicotinamide than mothers in the control group. However, most mothers taking analgesics, antacids, appetite suppressants, barbiturates, cough medicines, iron, sulphonamides, and vitamins produced normal infants. Any teratogenic effect of these drugs is therefore one of low potency. On the other hand, deficiencies such as those of ascorbic acid and folic acid may have a teratogenic effect. There is need for caution in presuming teratogenic effects on the basis of the associations shown here. During pregnancy, however, it would appear wise to avoid the administration of any drug which carries a suspicion of teratogenicity unless that drug is specifically indicated, and selfmedication with common household remedies such as aspirin and antacids should be avoided. These recommendations would also apply to any woman of childbearing age in whom conception is likely. IntroductionAs part of a survey into the aetiology of congenital malforrnations the drug consumption of pregnant mothers, both of

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“…Some anencephalics are probably lost as early abortions (Nishimura, Takano, Tanimura, Yasuda, and Uchida, 1966), but the suggestion that excessive losses of males account for the great preponderance of females that reach the 28th week of gestation is not borne out by what little evidence is available. Indeed the evidence suggests that female anencephalics are less viable and tend to have the shorter gestations.…”

Section: Sex Ratiosmentioning

confidence: 99%