Major malformations of the central nervous system in Hungary.

Czeizel, Andr̀ew E.; Révész, C

doi:10.1136/jech.24.4.205

Cited by 47 publications

(29 citation statements)

References 33 publications

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“…Although later paternal age is associated with increasing mutation rates, many studies have considered paternal age and only one of which found a general pattern of increasing risk for NTDs associated with advancing paternal age. The majority of studies have failed to show a relationship between paternal age and risk for NTDs (Czeizel and Révész, 1970;Strassburg et al, 1983;Frecker and Fraser, 1987;Simpson et al, 1991;Chatkupt et al, 1994;Shaw et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

Onrat

Seyman²,

Konuk³

2009

Genet. Mol. Res.

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Section: Introductionmentioning

confidence: 99%

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

Onrat

Seyman²,

Konuk³

2009

Genet. Mol. Res.

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“…Entre seis y siete estudios con tamaños de efecto de 0,0 son necesarios para reducir el delta de tamaño de efecto de la población de 0,37 a un tamaño de efecto promedio de 0,20 para anencefalia, mientras que para espina bífida son necesarios entre trece y catorce estudios con tamaños de efectos 0,0 para reducir el delta de tamaño de efecto de la población de 0,65 a un tamaño de efecto promedio de 0,20. [6][7][8][9][10][11][12][13] podrían estar reflejando las diferentes proporciones de anencefalia y espina bífida. Se sabe que las madres de 40 años o mayores están en mayor riesgo para trisomía 13, 18, ó 21.…”

Section: Resultsunclassified

“…A pesar de que el orden de nacimiento y la edad materna no pudieron ser analizados en conjunto, muchos estudios sugieren un efecto independiente de estas dos variables 24,[33][34][35][36][37][38][39] . La mayoría de los estudios no han demostrado una relación entre edad paterna y riesgo para DTNs 7,18,35,[40][41][42][43][44] . No fue posible estudiar la edad paterna en el presente reporte, porque la mayoría de los estudios no incluían información respecto a la edad paterna.…”

Section: A R T í C U L O D E I N V E S T I G a C I ó Nunclassified

Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia

Vieira

Taucher

2005

Rev. méd. Chile

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“…The suggested average reporting ratio of the past years was 40%. Czeizel E. et al made a nationwide data collection to analyze the NTDs frequencies in Hungary between 1963-1967 [27]. They concluded that the frequency of NTDs was 2.95/ 1000 newborn babies in Hungary.…”

Section: Discussionmentioning

confidence: 99%

Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women: Improper Recommendations

Ponyi

Hauser

Müller

et al. 2008

Journal of the American College of Nutrition

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Background: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs. In Canada, the incidence of neuroblastoma has presented a considerable decrease of 60% as a result of enrichment cereal grain flours with synthetic folic acid. The aim of this study was to investigate the effect of folic acid intake by pregnant women on the incidence of NTDs and neuroblastoma.Methods: Regular folic acid intake has been recommended to pregnant women in Hungary since the eighties of the last century by health visitors eventually raking effect as an official protocol which had been released in 1997. During 2001During , 2002During and 2003, folic acid intake habits of pregnant women were evaluated by health visitors, proving to be successful in collecting data from 95.06% of the pregnant women. The incidence of NTDs has been registered by the Hungarian National Centre of Epidemiology, Department of Human Genetics and Teratology. The Pediatric Cancer Registry provided the incidence of neuroblastoma in children.Results: Consistent findings revealed a regular intake of supplementary folic acid products by 68.71% of the pregnant women. Out of these, 93.13% of pregnant women who were taking folic acid, started the supplementation after their 7 weeks of pregnancies, a time designated as the completion period of the development of the neural tube. The dose of folic acid supplementation was evaluated as less than 5 mg/day in 84.75% of the pregnant women. In Hungary, the incidence of NTDs has remained constant, while the incidence of neuroblastoma has shown constant slight increase in spite of the introduction of folic acid supplementation in 1997.Conclusions: Based on our experience, folic acid supplementation was initiated after the recognition of pregnancy and its application in a dose of lower than 5 mg/day neither decreased the incidence of NTDs nor did it have an effect on the neuroblastoma incidence. It is implicated that proper folic acid supplementation, which is started from the conception, can be achieved only with the enrichment of cereal grain flours.

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Major malformations of the central nervous system in Hungary.

Cited by 47 publications

References 33 publications

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia

Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women: Improper Recommendations

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