High incidence of suicidal ideation in a series of patients with sickle cell disease after hematopoietic stem cell transplantation

Mishkin, Adrienne D.; Cheung, Stephanie; Hoffman, Alison; Leimbach, Elizabeth J; Dosovitz, Simon M; Mapara, Markus Y.

doi:10.1182/bloodadvances.2021006752

Cited by 4 publications

(2 citation statements)

References 18 publications

(16 reference statements)

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“…There are no studies of psychiatric outcomes for adult patients with SCD undergoing HCT. Some of our authors (ADM, EJL and MYM) found a 43% rate of suicidal ideation in the year post‐transplant in a 14‐patient case series 214 . Others have found ongoing daily pain, fatigue, anxiety and depressed mood in patients with SCD recovering from HCT 82 .…”

Section: Considerations For Medical Comorbidities Of Sickle Cell Diseasementioning

confidence: 74%

“…Some of our authors (ADM, EJL and MYM) found a 43% rate of suicidal ideation in the year post-transplant in a 14-patient case series. 214 Others have found ongoing daily pain, fatigue, anxiety and depressed mood in patients with SCD recovering from HCT. 82 Studies of the prevalence of specific psychiatric diagnoses, clinical evaluations and potential interventions are needed for this population.…”

Section: Conside R Ations For M E Dica L Comor Biditi E S Of Sick L E...mentioning

confidence: 99%

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Psychiatric comorbidities in adults with sickle cell disease: A narrative review

Mishkin

Prince²,

Leimbach

et al. 2023

Br J Haematol

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SummaryAlthough descriptions of quality of life and patient reports of mood in sickle cell disease (SCD) have become more common in the literature, less is known about psychiatric illness prevalence, presentation, and treatment, particularly for adults. We provide a narrative review of what is known about common and debilitating psychiatric conditions such as depression, anxiety, and cognitive impairment, specifically for adults with SCD. We discuss the limitations of the current evidence, make provisional recommendations, and identify opportunities for research and improved care.

show abstract

Section: Considerations For Medical Comorbidities Of Sickle Cell Diseasementioning

confidence: 74%

Section: Conside R Ations For M E Dica L Comor Biditi E S Of Sick L E...mentioning

confidence: 99%

Psychiatric comorbidities in adults with sickle cell disease: A narrative review

Mishkin

Prince²,

Leimbach

et al. 2023

Br J Haematol

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Genetic Counselors' attitudes & perceptions regarding suicide risk assessment and identification in practice

Hershman,

Fernandes,

Ceulemans

et al. 2024

Journal of Genetic Counseling

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While the heritability of suicidal tendencies is debated, receipt of various genetic diagnoses has shown an increased risk of suicidal ideation and behavior while simultaneously conferring risk to mental health concerns that may further increase this risk. However, the role of genetic counselors (GCs) in assessing and addressing suicide risk remains underutilized. A 15‐item recruitment survey was distributed via the National Society of Genetic Counselors Student Research Survey Listserv, and interested individuals could opt to be contacted for an interview after completion. The data analysis included 107 survey responses and 15 semi‐structured interviews, which were conducted to explore whether GCs feel that formal suicide risk assessment (SRA) falls within their scope of practice and the frequency with which it is employed during counseling sessions. Additionally, the study examined GCs' experiences, comfort levels, and training in assessing for suicide risk. All interviews were transcribed verbatim and independently coded by two researchers. The coding scheme was systematically constructed, integrating both deductive and inductive coding methods to inform the authors' interpretive description of SRA in the clinic, with four major themes identified by content analysis. Most respondents reported that they had worried about a patient harming themselves or having suicidal thoughts. Most respondents agreed or strongly agreed that SRA is within a GC's scope of practice. Lack of training emerged as the primary barrier to assessing suicide risk and conducting risk assessments. Other barriers included low self‐efficacy, societal stigma, and personal discomfort, while access to social workers, natural inclination, and standardized screening tools served as facilitators. Despite encountering patients at risk of self‐harm and suicide, most GCs do not utilize SRA tools. Furthermore, GCs expressed a strong desire for additional training to enhance their skills in identifying and managing at‐risk patients. A multifocal approach to suicide risk reduction and education is required.

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Life after sickle cell disease, is it really uhuru?

Pecker,

Akinsete,

Carroll

et al. 2023

The Lancet Haematology

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High incidence of suicidal ideation in a series of patients with sickle cell disease after hematopoietic stem cell transplantation

Cited by 4 publications

References 18 publications

Psychiatric comorbidities in adults with sickle cell disease: A narrative review

Psychiatric comorbidities in adults with sickle cell disease: A narrative review

Genetic Counselors' attitudes & perceptions regarding suicide risk assessment and identification in practice

Life after sickle cell disease, is it really uhuru?

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