High-Intensity Interval Training Does Not Change Vaspin and Omentin and Does Not Reduce Visceral Adipose Tissue in Obese Rats

Costa, Leandro Ribeiro; Castro, Cynthia Aparecida de; Marine, Diego Adorna; Fabrizzi, Fernando; Furino, Vanessa de Oliveira; Malavazi, Iran; Aníbal, Fernanda de Freitas; Duarte, Ana Cláudia Garcia de Oliveira

doi:10.3389/fphys.2021.564862

Cited by 11 publications

(7 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We could not prove if these proteins are a direct cause of HF, but if it is confirmed in further studies, the treatment targeting this inflammatory pathway should be beneficial; however, if it is only a marker of the disease it could still help us to identify patients who are in a more advanced state in the moment of the diagnosis and improve the following-up of patients with a higher risk of a new event. Some studies were not able to demonstrate that physical activity might improve the omentin levels in a rat obese model ( Costa et al, 2021 ). Other authors have suggested a benefit from metformin in women with polycystic ovary syndrome ( Tan et al, 2010a ).…”

Section: Discussionmentioning

confidence: 99%

A New Biomarker Tool for Risk Stratification in “de novo” Acute Heart Failure (OROME)

et al. 2022

View full text Add to dashboard Cite

Background: Inflammation is one of the mechanisms involved in heart failure (HF) pathophysiology. Thus, the acute phase reactant protein, orosomucoid, was associated with a worse post-discharge prognosis in de novo acute HF (AHF). However, the presence of anti-inflammatory adipokine, omentin, might protect and reduce the severity of the disease. We wanted to evaluate the value of omentin and orosomucoid combination for stratifying the risk of these patients.Methods and Results: Two independent cohorts of patients admitted for de novo AHF in two centers were included in the study (n = 218). Orosomucoid and omentin circulating levels were determined by ELISA at discharge. Patients were followed-up for 317 (3–575) days. A predictive model was determined for the primary endpoint, death, and/or HF readmission. Differences in survival were evaluated using a Log-rank test. According to cut-off values of orosomucoid and omentin, patients were classified as UpDown (high orosomucoid and low omentin levels), equal (both proteins high or low), and DownUp (low orosomucoid and high omentin levels). The Kaplan Meier determined a worse prognosis for the UpDown group (Long-rank test p = 0.02). The predictive model that includes the combination of orosomucoid and omentin groups (OROME) + NT-proBNP values achieved a higher C-index = 0.84 than the predictive model with NT-proBNP (C-index = 0.80) or OROME (C-index = 0.79) or orosomucoid alone (C-index = 0.80).Conclusion: The orosomucoid and omentin determination stratifies de novo AHF patients into the high, mild, and low risk of rehospitalization and/or death for HF. Its combination with NT-proBNP improves its predictive value in this group of patients.

show abstract

Section: Discussionmentioning

confidence: 99%

A New Biomarker Tool for Risk Stratification in “de novo” Acute Heart Failure (OROME)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…These include both classical cytokines, such as IL-6, TNF-α, IL-10, or chemokine (C-C motif) ligand 2 (CCL2), as well as leptin, adiponectin, resistin, visfatin, omentin, chemerin, and apelin. It has been shown that HFD leads to the overexpression of classical cytokines, leptin, chemerin, and apelin, while the expression of adiponectin, resistin, and visfatin is reduced (Hotamisligil et al, 1993;Kępczyñska et al, 2013;Murabayashi et al, 2013;Diba et al, 2018;Ding et al, 2018;Lu et al, 2018;Huang et al, 2019;Zhao et al, 2020a;Costa et al, 2021). Maternal hyperleptinemia has been suggested to induce leptin withdrawal in the fetal brain, resulting in the downregulation of leptin receptors and leptin signaling leading to cognitive impairment (Ding et al, 2018).…”

Section: Evidence Of Maternal Adipose Tissuefetal Brain Adipokine Axismentioning

confidence: 99%

The impact of maternal high-fat diet on offspring neurodevelopment

et al. 2022

View full text Add to dashboard Cite

A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on their brain health and behavior. During the past three decades, obesity has rapidly increased in the whole human population worldwide, including women of reproductive age. It is known that maternal obesity caused by a high-fat diet may lead to neurodevelopmental disorders in their offspring, such as autism spectrum disorder, attention deficit hyperactivity disorder, anxiety, depression, and schizophrenia. A maternal high-fat diet can affect offspring neurodevelopment due to inflammatory activation of the maternal gut, adipose tissue, and placenta, mirrored by increased levels of pro-inflammatory cytokines in both maternal and fetal circulation. Furthermore, a maternal high fat diet causes gut microbial dysbiosis further contributing to increased inflammatory milieu during pregnancy and lactation, thus disturbing both prenatal and postnatal neurodevelopment of the offspring. In addition, global molecular and cellular changes in the offspring’s brain may occur due to epigenetic modifications including the downregulation of brain-derived neurotrophic factor (BDNF) expression and the activation of the endocannabinoid system. These neurodevelopmental aberrations are reflected in behavioral deficits observed in animals, corresponding to behavioral phenotypes of certain neurodevelopmental disorders in humans. Here we reviewed recent findings from rodent models and from human studies to reveal potential mechanisms by which a maternal high-fat diet interferes with the neurodevelopment of the offspring.

show abstract

“…HIIT improves the physical function, cardiovascular health and energy metabolism [24]. But, it is not yet clear how HIIT affects the transcription factors involved in lipid metabolism and which pathways are most influenced by performing HIIT [25]. In current study, we have evaluated carnitine, HIIT, and a combination of both on the expression of genes involved in metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the combination of carnitine-HIIT caused a significant decrease in the expression of SCD1 and SREBP-1c. The study by Costa and coauthors (2021) showed that HIIT reduces hepatic SREBP-1c expression [25]. Another study in obese individuals showed that HIIT reduced the lipogenic genes SREBP-1c and ACC [37].…”

mentioning

confidence: 99%

The Effect of High-intensity Interval Training and L-carnitine on the Expression of Genes Involved in Lipid and Glucose Metabolism in the Liver of Wistar Rats

Shahouzehi

Masoumi‐Ardakani

Nazari-Robati

et al. 2023

Braz. arch. biol. technol.

View full text Add to dashboard Cite

Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. Pyruvate Dehydrogenase Kinase 4 (PDK4) is one of the main enzymes that plays a critical role in metabolic flexibility. In the current study, we examined the expression of genes involved in metabolism in the liver of male rats. Thirty-two male Wistar rats (8 week-old) were randomly divided into 4 groups (n = 8); 1. Control, 2. Training (do HIIT training for 4 weeks), 3. LCAR (received 200 mg / kg of L-carnitine, daily), 4. Training + L-carnitine (LCAR-HIIT). The gene expression was measured by Real-time PCR and quantified by 2 -ΔΔCt method. Sterol regulatory elementbinding protein-1c (SREBP-1c) expression was significantly higher in the LCAR (p = 0.018) and HIIT (p = 0.001) group than in the LCAR-HIIT group. Stearoyl-Coenzyme A desaturase-1 (SCD1) expression in HIIT (p = 0.007, p < 0.001) and LCAR-HIIT (p < 0.001, p = 0.003) groups was significantly increased and decreased compared to the control group and LCAR group, respectively. PDK4 expression was significantly reduced by combination of LCAR-HIIT compared to the control group. In sum, the administration of carnitine and HIIT is very useful and can conduct this by reducing the expression of lipogenic genes such as SREBP-1c and SCD1 as well as increasing the expression of Carnitine palmitoyltransferase 1 (CPT1). HIGHLIGHTS• L-carnitine supplementation and performing High-intensity interval training (HIIT) showed beneficial effects in rats.• L-carnitine + HIIT reduced lipogenic genes expression.• The combination of L-carnitine and HIIT caused a significant weight control in rats.

show abstract

High-Intensity Interval Training Does Not Change Vaspin and Omentin and Does Not Reduce Visceral Adipose Tissue in Obese Rats

Cited by 11 publications

References 77 publications

A New Biomarker Tool for Risk Stratification in “de novo” Acute Heart Failure (OROME)

A New Biomarker Tool for Risk Stratification in “de novo” Acute Heart Failure (OROME)

The impact of maternal high-fat diet on offspring neurodevelopment

The Effect of High-intensity Interval Training and L-carnitine on the Expression of Genes Involved in Lipid and Glucose Metabolism in the Liver of Wistar Rats

Contact Info

Product

Resources

About