High-intensity interval training increasing ADP-ribosylation factor 6 and Cytochrome C in visceral adipose tissue of male Wistar rats

Rahmati, Masoud; Shariatzadeh, Mohammad; Kazemi, Abdolreza; Taherabadi, Seyed Jalal

doi:10.1016/j.obmed.2019.100089

Cited by 1 publication

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“…We concluded that ARF6 is an important mediator of stress-induced plasticity in the nervous system in response to ET and neurodegeneration disease. In another study, we observed that the protein levels of ARF6 in visceral adipose tissue of male Wistar rats were significantly higher in the group receiving high-intensity interval training and this elevation could be related to improved metabolism and glucose homeostasis (19).…”

Section: Introductionmentioning

confidence: 86%

Exercise Training Enhances Expression of Tropomedulin-2 and ADP-Ribosylation Factor 6 in the Cerebellum of Male Wistar Rats

Taherabadi

Rahmati

2019

Zahedan J Res Med Sci

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Background: It has been well documented that exercise training (ET) induces beneficial effects on the central nervous system (CNS); however, the underlying mechanisms are less known. We presumed that actin cytoskeleton regulatory proteins such as ADPribosylation factors 6 (ARF6) and tropomodulin 2 (TMOD2) may be important elements of Exercise-Induced Neuroplasticity (EIN). We evaluated this hypothesis in the present study. Methods: We randomly divided 12 male Wistar rats into control (C) and training (T) groups. The T group was exposed to six weeks of moderate-intensity treadmill running. The ARF6 and TMOD2 gene and protein expressions in the cerebellum of male Wistar rats were assessed by the real-time PCR and western blot analysis. Results: The results showed that TMOD2 and ARF6 gene and protein expressions were significantly higher in the T group than in the C group. Conclusions: It seems that chronic treadmill running increases TMOD2 and ARF6 gene and protein expressions in the cerebellum and these changes probably lead to the improvement of brain function.

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Section: Introductionmentioning

confidence: 86%