High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats

Freitas, Daniel Almeida; Rocha‐Vieira, Etel; Soares, Bruno Alvarenga; Nonato, Luiza Fernandes; Fonseca, Sueli R.; Martins, João; Mendonça, Vanessa Amaral; Lacerda, Ana Cristina Rodrigues; Massensini, André Ricardo; Poortamns, Jacques R.; Meeusen, Romain; Leite, Hércules Ribeiro

doi:10.1016/j.physbeh.2017.10.027

Cited by 90 publications

(59 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As there is limited research on humans regarding the effect of intensity on BDNF, we are unable to draw a conclusion based on the literature and this study's results. In saying this, there is evidence suggesting that BDNF plays a key role in cognition, and that BDNF may increase with aerobic exercise training as the chronic production of BDNF seems to mediate improvements in executive function in a long-term intervention [59].…”

Section: Discussionmentioning

confidence: 99%

Effect of High Intensity Interval Training Compared to Continuous Training on Cognitive Performance in Young Healthy Adults: A Pilot Study

et al. 2020

View full text Add to dashboard Cite

To improve cognitive function, moving the body is strongly recommended; however, evidence regarding the proper training modality is still lacking. The purpose of this study was therefore to assess the effects of high intensity interval training (HIIT) compared to moderate intensity continuous exercise (MICE), representing the same total training load, on improving cognitive function in healthy adults. It was hypothesized that after 6 weeks (3 days/week) of stationary bike training, HIIT would improve executive functions more than MICE. Twenty-five participants exercised three times a week for 6 weeks after randomization to the HIIT or MICE training groups. Target intensity was 60% of peak power output (PPO) in the MICE group and 100% PPO in the HIIT group. After training, PPO significantly increased in both the HIIT and MICE groups (9% and 15%, p < 0.01). HIIT was mainly associated with a greater improvement in overall reaction time in the executive components of the computerized Stroop task (980.43 ± 135.27 ms vs. 860.04 ± 75.63 ms, p < 0.01) and the trail making test (42.35 ± 14.86 s vs. 30.35 ± 4.13 s, p < 0.01). T exercise protocol was clearly an important factor in improving executive functions in young adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of High Intensity Interval Training Compared to Continuous Training on Cognitive Performance in Young Healthy Adults: A Pilot Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To diminish stress in the animals, the rats in the exercise groups were adapted to a rodent treadmill for 5 days (at a speed of 10 m/min at 0% inclination for 5 min/day) [16,17]. The process of exercise training is described in our previous study [18].…”

Section: Exercise Trainingmentioning

confidence: 99%

Effects of Exercises on IL-6 and GLUT4 Expression in Diabetic Rats

Dehghan

Farzanegi

Abbaszadeh

2019

RMM

View full text Add to dashboard Cite

Background: Diabetes mellitus is one of the most common metabolic disorders worldwide. Empirical evidence has shown exercise to be of value in ameliorating symptoms of diabetes, but the underlying molecular mechanisms involved have not been well-studied. To evaluate the effects of continuous and interval exercises on blood glucose and insulin levels and on IL-6 and GLUT4 expression in diabetic rats. Materials and Methods: Old Wistar rats with streptozotocin-induced diabetes were randomly divided into three groups; namely, the patient (non-exercise control) group, the interval exercise group, and the continuous exercise group. The blood insulin level was measured using a specific ELISA kit, whereas the blood glucose level was determined with an AutoAnalyzer apparatus. Expression of the IL-6 and GLUT4 genes in skeletal muscle was determined using real-time PCR. All data were analyzed using SPSS software. Results: The expression of IL-6 and GLUT4 was significantly decreased in skeletal muscle of the diabetic rats (p < 0.001). Continuous (9.97-fold; p = 0.000) and interval (7.11-fold; p = 0.000) exercises significantly increased the expression of IL-6 relative to that in the animals of the patient group. Furthermore, continuous (9.36-fold; p = 0.000) and interval (7.65-fold; p = 0.001) exercises also significantly increased the expression of GLUT4 relative to that of the patient group. Both types of exercise training were associated with a significant decrease in the blood glucose and insulin levels compared with the levels in the patient group (p < 0.0001). Conclusions: Diabetes is significantly associated with IL-6 and GLUT4 downregulation, but this can be reversed through continuous and interval exercises, which also help to lower the blood glucose and insulin levels significantly.

show abstract

“…Several studies suggest that the status of oxidative stress regulated by reactive oxygen species (ROS) generation may affect BDNF expression 23,24,[28][29][30][31][32] . There are many antioxidant markers, but it remains unknown which antioxidant marker is applicable to reflect antioxidant status relating to BDNF levels in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Caloric restriction suppresses exercise-induced hippocampal BDNF expression in young male rats

Dobashi

Aiba

Ando

et al. 2018

JPFSM

View full text Add to dashboard Cite

Both exercise training and chronic caloric restriction contribute to brain health through enhanced expression of brain-derived neurotrophic factor (BDNF). This study investigated the synergistic effects between 12-week low-intensity exercise training and caloric restriction on hippocampal BDNF expression with redox status in rats. Twenty-six, 7-weekold male Wistar rats were randomly divided into the following 4 groups: (1) sedentary control (Con, n = 7), (2) exercise (Ex, n = 6), (3) caloric restriction (CR, n = 7), and (4) caloric restriction and exercise training (ExCR, n = 6). Although Con and Ex rats were fed ad libitum over time, CR and ExCR rats consumed 40% less food compared to Con rats. Ex and ExCR rats underwent low-intensity treadmill running (30 min/day, 5 days/week). Forty-eight hours after the termination of the 12-week intervention, rats were sacrificed and the hippocampus was quickly dissected for measuring BDNF expression and markers of oxidative stress, including 4-hydroxy-2-nonenal (4-HNE). Hippocampal BDNF expression was significantly increased in Ex compared to Con rats (p = 0.007), whereas the exercise-induced increase in BDNF was completely suppressed by a combination with caloric restriction. Furthermore, we observed a significant relationship between hippocampal BDNF and 4-HNE expression (r = 0.725, p < 0.001). Our findings indicate that exercise training combined with caloric restriction might not have a synergistic effect on hippocampal BDNF expression in young rats. Moreover, exerciseinduced oxidative stress can trigger BDNF expression in the hippocampus.

show abstract

High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats

Cited by 90 publications

References 51 publications

Effect of High Intensity Interval Training Compared to Continuous Training on Cognitive Performance in Young Healthy Adults: A Pilot Study

Effect of High Intensity Interval Training Compared to Continuous Training on Cognitive Performance in Young Healthy Adults: A Pilot Study

Effects of Exercises on IL-6 and GLUT4 Expression in Diabetic Rats

Caloric restriction suppresses exercise-induced hippocampal BDNF expression in young male rats

Contact Info

Product

Resources

About