High Intensity Interval Training Reduces the Levels of Serum Inflammatory Cytokine on Women with Metabolic Syndrome

Abstract

This study investigate the effects of a high intensity interval training (HIIT) and 2 weeks of detraining in functional and body composition parameters, lipoproteins, glucose metabolismand inflammation markers in postmenopausal women with metabolic syndrome (MS). 17 untrained women with MS underwent a HIIT program for 12 weeks. The training was performed in treadmills, 3 days per week, with intensity ranging from 70-90% of the maximum heart rate (HR) and 2 weeks untrained (inactive). Functional and body composition parameters were evaluated before and after the training, while maximal oxygen uptake, lipoprotein and inflammation markers were analyzed before, after training and also in detraining. The HITT program resulted in changesparameters as glucose, HbA1cand NOx after training. In addition, a reduction in pro-inflammatory interleukins and an increase in IL-10 after the HIIT program were found. However, an increase in plasma levels of lipoprotein was found and body composition parameters remain unaltered.Besides, only 2 weeks of detraining are able to revert the effects on inflammatory parameters afforded by the HIIT program. The HIIT program used here positively affected inflammatory profile and other parameters, as glucose, HbA1cand NOx, on postmenopausal women with MS. Moreover, 2 weeks of detraining can reverse the beneficial effects of HIIT program. Our results point out the necessity to aply acontinuous HITT program, in order maintain the benefits detected, to post menopausal women with MS.

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

“…In our study, 4 weeks of HIIT performed twice a week increased VO 2Peak and time to exhaustion in postmenopausal obese women. In fact, our results are in the line of previous data who demonstrated the role of HIIT on the positive adaptations of cardiorespiratory fitness in postmenopausal women …”

“…Interestingly, lower IL‐6 levels and higher IL‐10, and IL‐1ra concentrations at rest were observed after 4 weeks of HIIT. Similar to us, previous results also found a significantly reduction in plasmatic proinflammatory cytokines (MCP‐1, IL‐6, and TNF‐α) in postmenopausal women with metabolic syndrome, while IL‐10 levels were upregulated after HIIT over 2‐12 weeks . The anti‐inflammatory adaptations of exercise has been associated with lower rates of the chronic diseases development in postmenopausal women, indicating the great contribution of HIIT to the health improvements.…”

“…Recently, high intensity interval training (HIIT) emerges as a time‐efficient alternative compared with traditional exercise recommendations to promote positive metabolic and physiological adaptations with a lower commitment of week time . Although there is growing evidence that HIIT improves inflammation and cardiometabolic health, there is less evidence of the impact of HIIT on systemic inflammation in postmenopausal obese women . The high intensity adopted in HIIE may induce an acute proinflammatory response in postmenopausal women that can attenuate the positive chronic adaptations of HIIT.…”

Long-term Effects of Moderate versus High Durations of Aerobic Exercise on Biomarkers of Breast Cancer Risk: Follow-up to a Randomized Controlled Trial

“…© 2019 American Association for Cancer Research. cebp.aacrjournals.org Downloaded from or 4 weeks (42) after exercise, biomarker improvements may be lost partially (40) or completely (41,42) for insulin resistance indicators (40,42), fasting glucose, and inflammatory markers (41). Yet other detraining studies showed that improvement in insulin-stimulated glucose uptake per unit plasma unit (M/I; ref.…”

Treinamento intervalado de alta intensidade e contínuo de moderada intensidade reduzem interleucina-6, mas exercem limitadas mudanças cardiometabólicas em mulheres obesas: estudo randomizado e controlado

“…Destaca-se tais fatores, pois, é evidenciado redução limitada da gordura visceral e adipocitocinas pró-inflamatórias com exercício aeróbio moderado em homens (Cooper et al, 2016). Por outro lado, mulheres com excesso de peso e SM que realizaram treinamento aeróbio em alta intensidade, apresentam redução da inflamação sistêmica, redução da pressão arterial sistólica e diastólica (PAS e PAD), melhora glicêmica e aumento do consumo pico de oxigênio (VO2pico) ou VO2máx (Steckling et al, 2016;Allen et al, 2017). Com isso, mostra-se no mínimo oportuno, conhecer mais profundamente o treinamento aeróbio em alta intensidade e sua contribução positiva na melhoria da saúde cardiometabólica dos sujeitos obesos.…”