High lethality of human adenovirus disease in adult allogeneic stem cell transplant recipients with high adenoviral blood load

Ganzenmueller, Tina; Buchholz, Stefanie; Harste, Gabi; Dammann, Elke; Trenschel, Rudolf; Heim, Albert

doi:10.1016/j.jcv.2011.06.005

Cited by 53 publications

(57 citation statements)

References 33 publications

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“…A fatal outcome is particularly frequent in cases of DNAemia associated with disseminated disease, with reported lethality rates reaching up to 60 to 80% for both children and adults (69,71,131,186).…”

Section: Clinical Presentations and Outcomes Of Hadv Infections In Somentioning

confidence: 99%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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SUMMARY Human adenoviruses (HAdVs) are an important cause of infections in both immunocompetent and immunocompromised individuals, and they continue to provide clinical challenges pertaining to diagnostics and treatment. The growing number of HAdV types identified by genomic analysis, as well as the improved understanding of the sites of viral persistence and reactivation, requires continuous adaptions of diagnostic approaches to facilitate timely detection and monitoring of HAdV infections. In view of the clinical relevance of life-threatening HAdV diseases in the immunocompromised setting, there is an urgent need for highly effective treatment modalities lacking major side effects. The present review summarizes the recent progress in the understanding and management of HAdV infections.

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Section: Clinical Presentations and Outcomes Of Hadv Infections In Somentioning

confidence: 99%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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“…But studies since have shown that peripheral blood is probably the most important source for clinical surveillance of adenoviral infections in the immunocompromised setting [71,72]. A number of studies have attempted to correlate viral load to severity in order to determine when to start antiviral treatment but further work is required in order to determine whether this approach will affect patient care [73,74].…”

Section: Workupmentioning

confidence: 99%

The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

Khanal¹,

Ghimire²,

Dhamoon³

2018

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Abstract:Adenovirus is a family of double stranded DNA viruses that are a significant cause of upper respiratory tract infections in children and adults. Less commonly, the adenovirus family can cause a variety of gastrointestinal, ophthalmologic, genitourinary, and neurologic diseases. Most adenovirus infections are self-limited in the immunocompetent host and are treated with supportive measures. Fatal infections can occur in immunocompromised patients and less frequently in the healthy. Adenoviral vectors are being studied for novel biomedical applications including gene therapy and immunization. In this review we will focus on the spectrum of adenoviral infections in humans.

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“…Data relating to incidence and mortality of HAdV infections in adult SCT recipients are limited, but indicate a lower incidence (2-5%) and mortality (0-1%) than in children [4,11]. However, if HAdV disseminated disease occured in adult SCT patients, a high lethality (up to 60%) was observed similar to that in pediatric SCT recipients [4,11].…”

Section: Clinical Relevance Of Hadv Infections In Sct Patientsmentioning

confidence: 99%

“…By contrast, several studies have reported that HAdV load testing by quantitative PCR is useful for the early diagnosis of disseminated disease. Furthermore, a correlation between high virus loads and a fatal outcome has been described [9,11,13,14]. For example, a study reported HAdV DNAemia in 13 out of 48 (27.1%) pediatric SCT recipients.…”

Section: Hadv Load Diagnosticsmentioning

confidence: 99%

“…We recently showed in a retrospective study that seven out of 27 adult SCT recipients with peak HAdV blood loads above 10 4 copies/ml died from fatal HAdV disease (with peak loads up 10 9 copies/ml), while none of the patients with peak loads below this arbitrary threshold died from adenovirus disease [11]. Moreover, all patients with a fatal outcome had peak loads >10 7 copies/ml.…”

Section: To Treat or Not To Treatmentioning

confidence: 99%

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High lethality of human adenovirus disease in adult allogeneic stem cell transplant recipients with high adenoviral blood load

Cited by 53 publications

References 33 publications

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

Advances in the management of disseminated adenovirus disease in stem cell transplant recipients: impact of adenovirus load (DNAemia) testing

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