“…Tumor cells are characterized by their elevated metabolic rate, resulting in the escalation of the sequential toxic metabolites, including MG and SLG [9,10]. Tumor cells counter that by intensifying the activity of both Glo-I and Glo-II [8,11,12,13] as reported in multiple cancers such as stomach cancer [14,15], murine fibrosarcoma [16], pancreatic cancerous tissues [17], colon cancer [18], prostate cancers [19], and endometrial cancer cells [20]. Inhibition of Glo-I enzyme in cancer cells will lead to the accumulation of MG, leading to cytotoxicity and, subsequently, self-destruction of the cancer cells [7,21,22].…”