High level of dietary olive oil decreased growth, increased liver lipid deposition and induced inflammation by activating the p38 MAPK and JNK pathways in large yellow croaker (Larimichthys crocea)

Li, Xueshan; Chen, Kun; Fang, Wei; Chen, Qiang; Xu, Dan; Mai, Kangsen; Zhang, Yanjiao; Ai, Qinghui

doi:10.1016/j.fsi.2019.08.062

Cited by 57 publications

(39 citation statements)

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“…through a reduction of fat intake and increas of the intake of complex carbohydrate and/or recommend a change of dietary pattern towards a `Mediterranean diet´ or modification of the latter often associated with a switch of fat source to olive oil [ 42 – 44 ]. Some human and animal studies suggest that olive oil may bear some beneficial effects on the development of insulin resistance and NAFLD even in the absence of other dietary factors associated with the consumption of a `Mediterranean diet´ [ 45 , 46 ]; however, results of other studies report no or even unfavorable health effects of olive oil [ 23 , 24 ]. Here, using a pair-feeding model in mice, we assessed, if exchanging butterfat with equivalent amounts of an extra virgin olive oil bears protective effects on the progression of insulin resistance and/or development of NAFLD.…”

Section: Discussionmentioning

confidence: 99%

“…fatty acids and polyphenols are discussed to exert beneficial effects in settings of insulin resistance and NAFLD (for overview see [ 17 , 21 ]); however, to date, data from animal and human studies evaluating the isolated effects of olive oil on the liver and/ or insulin resistance are limited and at times contradictory. Indeed, while some studies suggest that polyphenol-rich extra virgin olive oils may possess beneficial effects in regard to the development of liver diseases, and herein, especially NAFLD [ 22 ], results of other studies reported no or even adverse effects [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance

et al. 2020

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Dietary fat is discussed to be critical in the development of non-alcoholic fatty liver disease. Here, we assess the effect of exchanging dietary fat source from butterfat to extra virgin olive oil on the progression of an already existing diet-induced non-alcoholic fatty liver disease in mice. Female C57BL/6J mice were fed a liquid butterfat-, fructose-and cholesterolrich diet (BFC, 25E% from butterfat) or control diet (C, 12%E from soybean oil) for 13 weeks. In week 9, fat sources of some BFC-and C-fed mice were switched either to 25E% or 12E% olive oil (OFC and CO). Glucose and insulin tolerance tests were performed, and markers of liver damage and glucose metabolism were assessed. After 6 weeks of feeding, BFC-fed mice had developed marked signs of insulin resistance, which progressed to week 12 being not affected by the exchange of fat sources. Liver damage was similar between BFC-and OFC-fed mice. Markers of lipid metabolism and lipid peroxidation in liver and of insulin signaling in liver and muscle were also similarly altered in BFC-and OFC-fed mice. Taken together, our data suggest that exchanging butterfat with extra virgin olive oil has no effect on the progression of non-alcoholic fatty liver disease and glucose tolerance in mice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance

et al. 2020

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“…Consequently, olive oil, when added to the diet, had a beneficial role in decreasing the liver damage induced by both aluminum and acrylamide. Also, Li et al (2019) who found an increase in serum ALT in the fish fed the diet with 100% olive oil compared with the control group.…”

Section: Discussionmentioning

confidence: 95%

Pickled olives neutralize vicine and convicine glycosides in Vicia faba and protect from favism

Koriem¹,

Arbid²

2020

NFS

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Purpose This paper aims to evaluate hematological parameters, blood glutathione (GSH), serum glucose-6-phosphate dehydrogenase (G6-PD) and liver function in favism animals' models after oral intake with a mixture of pickled olives and Vicia faba (V. faba) seeds. Design/methodology/approach Favism is a life-threatening hemolytic crisis. It results from the ingestion of V. faba by the individuals. The hemoglobin (Hb), hematocrit (Hct), red blood cells (RBCs), white blood cells (WBCs), serum glucose, blood GSH, serum G6-PD, serum thiobarbaturic acid reactive substances (TBARS), liver protein and liver function were evaluated after oral administration with a mixture of pickled olives with V. faba seeds in favism animals' models. Findings The favism-, vicine- and convicine-treated animals showed a significant decrease (p < 0.01) in Hb (6.42, 7.23 and 5.96 g/dl), Hct (25.4, 26.4 and 25.1%), RBCs (2.56, 2.45 and 2.60 106 cells/mm3, WBCs (4.35, 4.25 and 4.30 103 cells/mm3), serum glucose (95.8, 97.1 and 96.5 mg/dl), blood GSH (24.7, 26.6 and 23.8 mg/dl), serum G6-PD (15.8, 15.9 and 15.7 U/L), serum aspartate aminotransferase (6.35, 6.59 and 5.97 U/L), alanine aminotransferase (4.49, 4.61 and 4.50 U/L), total protein (6.54, 6.59 and 6.40 g/dl), albumin (3.84, 3.91 and 3.75 g/dl), globulin (2.70, 2.48 and 2.65 g/dl) and liver protein (3.37, 3.10 and 3.42 g/g tissue) but a significant increase (p < 0.01) in serum TBARS (38.7, 38.9 and 39.4 nmol/dl), alkaline phosphatase (275, 271 and 281 U/L) and total bilirubin (0.93, 0.89 and 0.91 mg/dl) compared to Hb (16.3 g/dl), Hct (45.3%), RBCs (5.80 106 cells/mm3), WBCs (9.45 103 cells/mm3), serum glucose (96.5 mg/dl), blood GSH (39.7 mg/dl), serum G6-PD (36.1 U/L), serum TBARS (18.0 nmol/dl), serum aspartate aminotransferase (19.8 U/L), alanine aminotransferase (9.23 U/L), alkaline phosphatase (214 U/L), total bilirubin (0.57 mg/dl), total protein (8.76 g/dl), albumin (4.85 g/dl), globulin (3.91 g/dl) and liver protein (6.28 g/g tissue) in control group. The oral administration with pickled olives + V. faba, pickled olives + vicine and pickled olives + convicine into favism animals' models, vicine-treated animals and convicine-treated animals, respectively pushed all the above-mentioned parameters to near the control levels. Originality/value V. faba contains vicine and convicine glycosides. Vicine and convicine glycosides in V. faba are hydrolyzed by intestinal microflora to aglycones divicine and isouramil, respectively. Divicine and isouramil are highly reactive compounds generating free radicals where divicine and isouramil are the main factors of favism. The ß-glucosidase in pickled olives converts both vicine and convicine glycosides into aglycones divicine and isouramil, respectively, in aerobic condition outside the human body (in inactive forms) and prevent these glycosides to cause favism.

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“…Vegetable oils (VO) have the advantages of high yield, wide source and low price, which make it become the preferred source substitute for FO. At present, corn oil (Lin & Shiau, 2007), sunflower oil (Bransden et al., 2003), tea seed oil (Han et al., 2013), olive oil (Li, et al., 2019) and rice oil (Gandomkar et al., 2013) have been used in aquatic animal feed production. Nevertheless, due to the large amount of linoleic acid (c18:2n‐6) and linolenic acid (c18:3n‐3) in VO, and the relative lack of LC‐PUFA, replacing FO with VO will lead to the decrease of the content of LC‐PUFA in diets (Yıldız et al., 2018), which will affect the lipid metabolism of fish, and further affect the antioxidant and anti‐stress ability of fish (Peng et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of alternative dietary oils on lipid metabolism and related gene expression in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu )

et al. 2020

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An 8‐week growth trial was conducted to evaluate effects of dietary oil sources on growth, enzymes activity and genes expression levels related to lipid metabolism of hybrid grouper (♀Epinephelus fuscoguttatus × ♂E. lanceolatu) juveniles. Seven iso‐lipid (97 g/kg of dry matter) and iso‐protein (503.5 g/kg of dry matter) experimental diets were formulated containing 50 g/kg fish oil (FO; acting as controls) or various vegetable oils (VOs): corn oil (CO), sunflower oil (SO), tea oil (TO), olive oil (OO), rice oil (RO) and mixed oil (MO; comprising equal amounts of these oils). Each diet was fed to triplicate groups of 40 fish for per repetition (15.09 ± 0.01 g) for 56 days. The results show that (a) alternative dietary oils had no significant effects on final weight compared with control group (p > .05); (b) compared with FO group, VOs significantly changed the contents of serum lipoproteins, cholesterol, triglycerides and the activity of liver lipid‐metabolizing enzymes (p < .05); (c) CO group had the least effect on the serum lipoproteins, triglycerides and cholesterol of grouper compared with control; the activity of liver lipid‐metabolizing enzymes in RO and control group was the closest; (d) the mRNA levels of Δ6 Fatty acid desaturase (Δ6Fad), hormone‐sensitive lipase (HSL) and lipoprotein lipase (LPL) were not significantly effected by lipid sources, but CO, TO, OO and MO significantly down‐regulated the expression of fatty acid synthetase (FAS) mRNA level in liver, while RO opposite (p < .05); (e) vegetable oil significantly up‐regulated peroxisome proliferator‐activated receptor α (PPARα) and peroxisome proliferator‐activated receptor β (PPARβ) mRNA levels, while TO and RO down‐regulated peroxisome proliferator‐activated receptor γ (PPARγ) mRNA levels (p < .05); and 6) MO significantly increased the mRNA levels of heart‐type fatty acid‐binding protein (H‐FABP) and adipocyte‐type fatty acid‐binding protein (A‐FABP) (p < .05), while other VOs had no effect on them (p > .05). In conclusion, dietary substitution of FO by VO in diet affected lipid metabolism of grouper, which may be regulated by PPARs.

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High level of dietary olive oil decreased growth, increased liver lipid deposition and induced inflammation by activating the p38 MAPK and JNK pathways in large yellow croaker (Larimichthys crocea)

Cited by 57 publications

References 54 publications

Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance

Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance

Pickled olives neutralize vicine and convicine glycosides in Vicia faba and protect from favism

Effects of alternative dietary oils on lipid metabolism and related gene expression in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu )

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