High level of homocysteine is associated with pre-eclampsia risk in pregnant woman: a meta-analysis

Zhang, Caihong; Hu, Jingjing; Wang, Xia; Gu, Hang

doi:10.1080/09513590.2022.2110233

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The excess Hcy is then excreted from the cells, leading to its increased concentration in the circulation [ 16 , 22 ]. High plasma Hcy concentrations have been linked to cardiovascular diseases [ 23 , 24 ], stroke [ 25 , 26 ], Alzheimer’s disease [ 27 , 28 ], schizophrenia [ 29 , 30 ], macular degeneration [ 31 ], diabetes [ 32 ], fractures [ 33 ], pregnancy complications [ 34 , 35 , 36 ], small-for-gestational-age offspring [ 37 ], and cancer [ 38 ]. This suggests that Hcy is an important indicator of health status [ 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women

Kubo

Shoji

Tajima

et al. 2023

IJMS

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Maintaining optimal one-carbon metabolism (OCM) is essential for health and pregnancy. In this cross-sectional study, folate status was assessed based on 5-methyltetrahydrofolate (5-MTHF) levels, and the association between 5-MTHF and OCM-related metabolites was investigated in 227 female Japanese university students aged 18–25 years. The participants were divided into high and low 5-MTHF groups based on their folate status. Serum samples of the participants were collected while they were fasting, and 18 OCM-related metabolites were measured using stable-isotope dilution liquid chromatography–electrospray tandem mass spectrometry. The association between serum 5-MTHF and OCM-related metabolite concentrations was assessed using Spearman’s rank correlation coefficient. Serum 5-MTHF concentrations were negatively correlated with total homocysteine (tHcy) concentrations and positively correlated with S-adenosylmethionine (SAM) and total cysteine (tCys) concentrations. Serum 5-MTHF concentrations demonstrated a stronger negative correlation with tHcy/tCys than with tHcy alone. The negative correlation between betaine and tHcy concentrations was stronger in the low 5-MTHF group than in the high 5-MTHF group. The 5-MTHF status could be linked to Hcy flux into the transsulfuration pathway via SAM. Therefore, the tHcy/tCys ratio may be a more sensitive indicator of the 5-MTHF status than tHcy alone. Furthermore, a low 5-MTHF status can enhance Hcy metabolism via betaine.

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Section: Introductionmentioning

confidence: 99%

Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women

Kubo

Shoji

Tajima

et al. 2023

IJMS

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“…This includes obesity, 103 exposure to air pollution, 104 systemic lupus erythematosus, 105 sarcoidosis, 106 periodontitis, urinary tract infections, and infections with Helicobacter pylori , coronavirus disease 2019 (COVID-19), 107 cytomegalovirus, herpes simplex virus type-2, HIV, Plasmodium spp., and Toxoplasma gondii . 108 Other hypofibrinolytic conditions present in the first trimester that increase the risk of preeclampsia are exemplified by ferroptosis, 109 hyperhomocysteinemia, 110 hypothyroidism, 111 Cushing's syndrome, 112 antiphospholipid antibodies, 113 and the 4G/4G polymorphism. 114…”

Section: Preeclampsiamentioning

confidence: 99%

The Impact of Emotional Responses on Female Reproduction: Fibrinolysis in the Spotlight

Hoirisch-Clapauch

2024

Semin Thromb Hemost

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Fibrinolytic enzymes modify various substrates required for tissue remodeling, playing a crucial role in mechanisms underlying resilience, reward processing, ovulation, embryo implantation, and placentation. Individuals with low resilience and reduced reward responsiveness, when exposed to chronic stress, are at increased risk of experiencing a range of negative emotions. Chronic anxiety and melancholia are examples of negative emotions associated with hypercortisolism, while fear and atypical depression are characterized by systemic inflammation. Both cortisol and inflammatory cytokines stimulate the production of plasminogen activator inhibitor-1 (PAI-1), a potent fibrinolysis inhibitor. Chronic anxiety, fear, and depression are among the many hypofibrinolytic conditions increasing the risk of oligo-anovulation, miscarriage, fetal growth restriction, and preeclampsia. Although significant, the impact of negative emotions on implantation is not as obvious as on ovulation or placentation. Other hypofibrinolytic conditions that may affect female reproduction through mechanisms dependent or independent of PAI-1 include metabolic disturbances (e.g., due to consumption of highly palatable foods, often used to alleviate negative affect), inflammation, hyperhomocysteinemia, hypothyroidism, hypercortisolism, antiphospholipid antibodies, and the 4G allele of the PAI-1 gene. Benzodiazepines and antidepressants should be used with caution in the first trimester as this combination may cause malformations. Also, selective serotonin reuptake inhibitors have fibrinolytic properties that increase the risk of bleeding after surgical procedures. Psychological interventions, especially group therapy, are effective in the prevention of reproductive disorders. Controlled trials are needed to test the hypothesis that female reproductive health depends on psychological well-being, a balanced diet and physical activity, suppression of inflammation and autoantibodies, and homocysteine and hormonal homeostasis.

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Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications

Zhang

Han

et al. 2023

BMC Public Health

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Background The joint effect of platelet and other modifiers on the risk of pregnancy complications is unknown. This study investigated whether platelet count (PC) and total homocysteine (tHcy) level have a synergistic effect on the incidence of pregnancy complications in a Chinese population. Methods Total 11,553 consecutive pregnant women who received whole blood cell and biochemical tests at the time of admission for labor in Changzhou Maternal and Child Health Care Hospital were analyzed. The primary outcome was the prevalence of pregnancy complications: gestational diabetes mellitus (GDM), intrahepatic cholestasis of pregnancy (ICP), pre-eclampsia (PE), and pregnancy induced hypertension (PIH). Results The prevalence of GDM, ICP, PE, and PIH was 8.4%, 6.2%, 3.4%, and 2.1%, respectively. The highest rate of ICP (28.6%) was observed in women with high tHcy (> 15 μmol/L) and low PC (quartile 1); and the lowest rate of GDM (0.6%) was found in women with high tHcy and high PC (quartiles 2 to 4). In low PC group, the prevalence of ICP in women with high tHcy was significantly higher than that in women with low tHcy (≤ 15 μmol/L) (28.6% vs. 8.4%), representing an absolute risk increment of 20.2% and a relative risk increment of 3.3-fold (OR: 3.34; 95% CI: 1.55, 7.17; P = 0.002), whereas no joint effect was observed among high PC group. Conclusions Among Chinese pregnant women, one subgroup (high tHcy and low PC) has the highest risk of ICP and another (high tHcy and high PC) has the lowest risk of GDM; tHcy and platelet could be used as indicators to identify the women with high risk of ICP or low risk of GDM.

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High level of homocysteine is associated with pre-eclampsia risk in pregnant woman: a meta-analysis

Cited by 3 publications

References 28 publications

Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women

Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women

The Impact of Emotional Responses on Female Reproduction: Fibrinolysis in the Spotlight

Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications

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