High Levels of DNA Fragmentation Observed in an Infertile Population Attending a Fertility Center are Related to Advanced Paternal Age

Garca-Ferreyra, Javier; Romero, Rocío García; Hilario, Roly; Dueñas-Chacón, Julio

doi:10.4172/2165-7491.1000113

Cited by 6 publications

(1 citation statement)

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“…Our findings are in line with those of a previous study conducted in Lima, Peru among infertile men aged of 30-39 and 40-49 with DFI of 39 percent and 42 percent respectively [13].…”

Section: Discussionsupporting

confidence: 93%

Sperm DNA Fragmentation in Saudi Infertile Men with Normal Standard Semen Parameters

Ghedan¹,

Matrafi²,

Sufyan³

et al. 2015

Andrology

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Almost 15% of infertile males have normal semen parameters and DNA Fragmentation Index (DFI) could be reasonably a valued tool for fertility extrapolation than the conventional semen analysis. To the best of our knowledge, this is the first study to assess the prevalence of high DFI in Saudi infertile men with normal standard semen parameters in order to support the generalizability about sperm DFI as a marker of male infertility. A total of 79 infertile men with normal semen standards were identified (study group). Standard semen analysis and sperm chromatin dispersion were carried out. 33 men (41.8% of the whole study group) had a DFI ≥ 20%; with 19 men (24.1%) (95% CI: 14.67-33.53) had a 20% ≤ DFI<30%, and 14 men (17.7 %) (95% CI: 9.28-26.12) had a DFI ≥ 30%. The mean DFI was 21.14% (±10.26%) with a median of 18.12% [5.09-57.23]. Our findings showed that a considerable proportion of men with normal semen parameters had high sperm DNA damage levels. Thus, the DFI by sperm chromatin dispersion test is essential to explain causes of infertility in cases where semen analysis has not shown any deviation from the norms.

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“…Our findings are in line with those of a previous study conducted in Lima, Peru among infertile men aged of 30-39 and 40-49 with DFI of 39 percent and 42 percent respectively [13].…”

Section: Discussionsupporting

confidence: 93%

Sperm DNA Fragmentation in Saudi Infertile Men with Normal Standard Semen Parameters

Ghedan¹,

Matrafi²,

Sufyan³

et al. 2015

Andrology

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The effect of preparatory therapy with myo-inositol on the outcome of infertility treatment by ART in men with low reproductive function

Feskov¹,

Zhylkova²,

Nesteruk³

et al. 2021

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Research objective: to study the effect of myo-inositol (MI), folic acid (FA) and cyanocobalamin in mono- and complex therapy on the classical fertility rates and the level of DNA fragmentation in sperm in men with low reproductive function, and on the results of the in vitro fertilization (IVF) programs performed in these patients.Materials and methods. A retrospective study of 133 patients aged 32 to 40 years was carried out for the period 2020–2021. All patients were divided into three groups: group 1 – 44 men who took MI, FA and cyanocobalamin daily as monotherapy for 3 months; group 2 – 42 patients who followed a diet to improve spermatogenesis for 3 months; group 3 – 47 men, for whom complex therapy was applied for 3 months: MI, FA, cyanocobalamin and diet.Results. The increase of sperm concentration in ejaculate, improvement of progressively motility of spermatozoa, and increase of the percent of spermatozoa with normal morphology in men with failures of reproductive function after the complex preparatory therapy are defined. The preparatory therapy for men with MI in preparation for IVF helps to improve the quality of embryos and increase the pregnancy rates in couples with male infertility due to the assisted reproductive technologies. The positive effect of preparatory complex therapy in patients with poor spermatogenesis on the blastocyst formation rates in IVF programs is shown.Conclusions. The positive effect of MI on the normal functioning of the reproductive system in men has been proven. The increase pregnancy rates in the IVF program after preparatory treatment of men with MI can be explained by its positive effect on reducing the level of DNA fragmentation of sperm.

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Correlation of Sperm DNA Fragmentation with Some Semen Parameters of Infertile Men in Iraqi Kurdistan Region

Al-Attar¹,

Hassan²

2016

ZJPAS

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High Levels of DNA Fragmentation Observed in an Infertile Population Attending a Fertility Center are Related to Advanced Paternal Age

Cited by 6 publications

References 0 publications

Sperm DNA Fragmentation in Saudi Infertile Men with Normal Standard Semen Parameters

Sperm DNA Fragmentation in Saudi Infertile Men with Normal Standard Semen Parameters

The effect of preparatory therapy with myo-inositol on the outcome of infertility treatment by ART in men with low reproductive function

Correlation of Sperm DNA Fragmentation with Some Semen Parameters of Infertile Men in Iraqi Kurdistan Region

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