High Levels of Maternal Serum IL‐17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus

Torricelli, Michela; Bellisai, Francesca; Novembri, Romina; Galeazzi, L; Iuliano, Annamaria; Voltolini, Chiara; Spreafico, Adriano; Gargiulo, Mauro

doi:10.1111/j.1600-0897.2011.00978.x

Cited by 29 publications

(17 citation statements)

References 48 publications

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“…In our study, serum levels of Th2 cytokines were similar in SLE patients compared with controls and only IL-10 was higher in SLE patients than in healthy women. These data are comparable to those recently published by Torricelli et al (33) who found higher serum levels of IL-10 in pregnant SLE patients compared with healthy pregnant women, and IL-10 serum levels progressively increased during pregnancy. Similarly, Muñoz-Valle et al (34) showed higher levels of IL-10 in pregnant SLE patients than in healthy pregnant women, particularly during the last trimester of pregnancy.…”

Section: Cytokine Serum Levelssupporting

confidence: 91%

Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus

et al. 2012

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Section: Cytokine Serum Levelssupporting

confidence: 91%

Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus

et al. 2012

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“…Moreover, our data appear similar to those recently published by Torricelli et al [40]. In their study, they also found higher levels of IL-10 in pregnant patients affected with SLE compared with healthy pregnant women.…”

Section: Discussionsupporting

confidence: 93%

Effect of pregnancy on serum cytokines in SLE patients

et al. 2012

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IntroductionThe aim of this study was to evaluate an extensive panel of cytokines involved in immune regulation during pregnancy in patients with systemic lupus erythematosus (SLE) and in healthy women.MethodsA total of 47 consecutive successful pregnancies in 46 SLE patients and 56 pregnancies in 56 matched healthy subjects, as controls, were prospectively studied. Serum interleukin (IL)-1-α, IL-1-β, IL-2, IL-6, IL-8, IL-10, IL-12p70, interferon (INF)-γ and tumor necrosis factor (TNF)-α were detected in sera obtained at the first and third trimester of pregnancy by a highly sensitive, multiplexed sandwich ELISA.ResultsMedians (pg/ml) of serum levels of most helper T (Th)1-type cytokines were significantly lower in the third trimester compared with those observed in the first trimester of pregnancy in healthy women: INF-γ 2.0 vs 3.4, TNF-α 10.2 vs 11.5, IL-1-α 0.9 vs 1.1, IL-1-β 0.6 vs 1.0, IL-2 3.0 vs 3.5, and IL-12p70 4.9 vs 5.6 (P-values < 0.02 for all). By contrast, only the IL-1-α serum levels were lower in the third trimester compared with the first trimester in SLE patients (P = 0.006). IFN-γ/IL-6 and IFN-γ/IL-10 ratios were higher in controls than in SLE (P = 0.002, and P = 0.001, respectively); moreover, they were significantly reduced in the third compared to the first trimester of pregnancy in healthy women, but not in SLE.ConclusionsIn SLE patients, Th1/Th2 cytokine serum level ratio does not decrease during pregnancy progression as much as in healthy pregnant women. This could account for the observation of a low frequency of disease flares in the third trimester of gestation.

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“…15,18 No significant difference in the expression profile of lupus and lupus nephritis subjects were observed in our study. [33][34][35] However, no such differences were observed in our study. Discrepancies observed in serum concentration of IL-17A and F and peripheral blood mRNA expression could be explained by the fact that IL-17 present in serum may originate from tissue-located cells and not necessarily only from Th-17 cells.…”

Section: Discussioncontrasting

confidence: 89%

Th-17 related regulatory network in the pathogenesis of Arab patients with systemic lupus erythematosus and lupus nephritis

2014

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High Levels of Maternal Serum IL‐17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus

Abstract: Women with SLE show increased secretions of activin A, IL-17, IL-6, IL-10, and TNF-α during gestation, with a different trend for the various cytokines. These data suggest that patients with SLE have a hyper-reactive immune system, probably receiving a placental contribution.

Cited by 29 publications

References 48 publications

Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus

Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus

Effect of pregnancy on serum cytokines in SLE patients

Th-17 related regulatory network in the pathogenesis of Arab patients with systemic lupus erythematosus and lupus nephritis

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