High levels of polychlorinated dibenzo-dioxins/furans and dioxin like-PCBs found in monitoring investigations of sheep liver samples from Lower Saxony, Germany

Bruns-Weller, Elke; Knoll, Annette; Heberer, Thomas

doi:10.1016/j.chemosphere.2009.12.014

Cited by 22 publications

(7 citation statements)

References 8 publications

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“…ewes). In 2011, EFSA evaluated the risks of consumption of sheep livers (EFSA CONTAM Panel, ) (see Section 1.3.3), following reports that these can contain high TEQ levels (Bruns‐Weller et al., ). Comparison with lipid‐based levels in meat and fat showed that the high levels point to sequestration in the liver.…”

Section: Assessmentmentioning

confidence: 99%

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

143

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The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in feed and food. The data from experimental animal and epidemiological studies were reviewed and it was decided to base the human risk assessment on effects observed in humans and to use animal data as supportive evidence. The critical effect was on semen quality, following pre‐ and postnatal exposure. The critical study showed a NOAEL of 7.0 pg WHO2005‐TEQ/g fat in blood sampled at age 9 years based on PCDD/F‐TEQs. No association was observed when including DL‐PCB‐TEQs. Using toxicokinetic modelling and taking into account the exposure from breastfeeding and a twofold higher intake during childhood, it was estimated that daily exposure in adolescents and adults should be below 0.25 pg TEQ/kg bw/day. The CONTAM Panel established a TWI of 2 pg TEQ/kg bw/week. With occurrence and consumption data from European countries, the mean and P95 intake of total TEQ by Adolescents, Adults, Elderly and Very Elderly varied between, respectively, 2.1 to 10.5, and 5.3 to 30.4 pg TEQ/kg bw/week, implying a considerable exceedance of the TWI. Toddlers and Other Children showed a higher exposure than older age groups, but this was accounted for when deriving the TWI. Exposure to PCDD/F‐TEQ only was on average 2.4‐ and 2.7‐fold lower for mean and P95 exposure than for total TEQ. PCDD/Fs and DL‐PCBs are transferred to milk and eggs, and accumulate in fatty tissues and liver. Transfer rates and bioconcentration factors were identified for various species. The CONTAM Panel was not able to identify reference values in most farm and companion animals with the exception of NOAELs for mink, chicken and some fish species. The estimated exposure from feed for these species does not imply a risk.

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Section: Assessmentmentioning

confidence: 99%

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

143

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“…In Figure , it may be noticed that PCDFs’ contribution to the cumulative TE values in liver is higher than that recorded in milk and muscle. The latter result is in good agreement with previous comparative studies in liver and muscle in pigs and sheep. , On an analytical basis the liver profiles indicate a relative reduction of tetra-, penta-, and hexa-PCDDs and of DL-PCB 169 in all three animals (Figures , , and ). With respect to tissues other than liver, the perirenal fat and the retrobulbar fat gave contradictory information: in two cases out of three both perirenal fat (animals A and C) and retrobulbar fat (animals B and C) showed cumulative values in line with that recorded in the corresponding milk (Table ).…”

Section: Resultsmentioning

confidence: 99%

Polychlorodibenzodioxin and -furan and Dioxin-like Polychlorobiphenyl Distribution in Tissues and Dairy Products of Dairy Buffaloes

Filippis

Chirollo

Brambilla

et al. 2013

J. Agric. Food Chem.

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A pilot study was performed on three different dairy buffalo herds exposed without exposure control conditions to Polychlorodibenzodioxins and -furans (PCDDs, PCDFs) and Dioxin-like Polychlorobiphenyls (DL-PCBs). This study dealt with the relationship between the contamination levels (pg WHO₂₀₀₅-TE/g fat) in individual raw milk and those in edible tissues and with the contamination transfer from farm bulk milk to dairy products. On a cumulative basis, kidney (41, 67, and 21 pg WHO-TE/g fat) resulted more in equilibrium with milk (48, 42, and 20) than did muscle (25, 31, and 9), while liver showed a large bioaccumulation (221, 304, and 75), with marked differences of the congener profile. Mozzarella cheese contamination (23, 42, and 29 pg WHO-TE/g fat) was higher than that of bulk milk (20, 36, and 21), which suggested a role of casein precipitation in congener transfer. The above information could improve the effectiveness of risk management during a "dioxin" crisis.

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“…However, but, overall, the pattern is inconsistent. In animals, endocrine, reproductive and developmental effects are among the most sensitive to dioxin exposure (Bruns-Weller et al 2010). Decreased sperm counts in rats and endometriosis in rhesus monkeys occur at concentrations 10 times higher than current human exposure (Kogevinas 2001).…”

Section: Health Effectsmentioning

confidence: 99%

Pollutant Diseases, Remediation and Recycling

2013

Environmental Chemistry for a Sustainable World

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High levels of polychlorinated dibenzo-dioxins/furans and dioxin like-PCBs found in monitoring investigations of sheep liver samples from Lower Saxony, Germany

Cited by 22 publications

References 8 publications

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Polychlorodibenzodioxin and -furan and Dioxin-like Polychlorobiphenyl Distribution in Tissues and Dairy Products of Dairy Buffaloes

Pollutant Diseases, Remediation and Recycling

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