High Levels of Serum Adipocyte Fatty Acid-binding Protein Predict Cardiovascular Events in Coronary Artery Disease Patients

Huang, I-Ching; Hsu, Bang‐Gee; Chang, C. M.; Lee, Chung‐Jen; Wang, Ji‐Hung

doi:10.7150/ijms.25588

Cited by 9 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In women with gestational diabetes, serum A-FABP level is independently correlated with impaired glucose metabolism and increases the risk of progression to DM [20]. In addition, higher levels of circulating A-FABP are believed to be a biomarker for predicting unfavorable CV events in patients with coronary artery disease, end-stage renal disease, or critical illness [13,21,22]. In ApoE-deficient mice and in the human microvascular endothelium, previous work shows that A-FABP has an independent role in atherogenesis; additionally, enhanced expression of A-FABP was associated with reduced expression of eNOS and nitric oxide (NO) production [19,23].…”

Section: Discussionmentioning

confidence: 99%

Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients

Chen

Lee

et al. 2019

Metabolites

Self Cite

View full text Add to dashboard Cite

Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes and is involved in cardiovascular disease. Our aim is to investigate the association between serum A-FABP levels and endothelial function among kidney transplant (KT) patients. Fasting blood samples were obtained from 80 KT patients. Serum A-FABP levels were measured using a commercially available enzyme immunoassay kit. Endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring test. In this study, VRI < 1.0, VRI 1.0–1.9, and VRI ≥ 2.0 were defined as poor, intermediate, and good vascular reactivity, respectively. There were 12 (15.0%), 30 (37.5%), and 38 (47.5%) KT patients categorized as having poor, intermediate, and good vascular reactivity, respectively. Increased serum levels of alkaline phosphatase (p = 0.012), γ-glutamyltranspeptidase (GGT; p = 0.032), and A-FABP (p < 0.001) were associated with decreased vascular reactivity. Multivariable forward stepwise linear regression analysis revealed that age (β = −0.283, adjusted R2 change = 0.072; p = 0.003) and serum log-A-FABP level (β = −0.514, adjusted R2 change = 0.268; p < 0.001) were significantly associated with VRI values in KT patients. We concluded that serum fasting A-FABP level is negatively associated with VRI values and plays a role in endothelial dysfunction of KT patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients

Chen

Lee

et al. 2019

Metabolites

Self Cite

View full text Add to dashboard Cite

show abstract

“…Height was measured to the nearest 0.5 cm, and body weight was measured to the nearest 0.5 kg in light clothing without shoes. Body mass index (BMI) was calculated as weight (kg) divided by height squared (m 2 ) [ 7 – 11 ].…”

Section: Methodsmentioning

confidence: 99%

“…Serum albumin, blood urea nitrogen (BUN), Cre, fasting glucose, triglyceride (TG), total cholesterol (TCH), total calcium, phosphorus, and C-reactive protein (CRP) levels were measured with an autoanalyzer (Siemens Advia 1800, Siemens Healthcare GmbH, Henkestr, Germany) [ 7 – 10 ]. Serum A-FABP (SPI-BIO, Montigny le Bretonneux, France) and intact parathyroid hormone (iPTH) levels (Diagnostic Systems Laboratories, TX, USA) were measured with a commercial enzyme immunoassay and enzyme-linked immunosorbent assay (ELISA) [ 8 – 11 ].…”

Section: Methodsmentioning

confidence: 99%

Positive Associations between Adipocyte Fatty Acid-Binding Protein Level and Central Arterial Stiffness in Peritoneal Dialysis Patients

Sung

Hsu

Tasi

et al. 2021

International Journal of Hypertension

Self Cite

View full text Add to dashboard Cite

Background. Adipocyte fatty acid-binding protein (A-FABP) plays essential roles in lipolysis, insulin resistance, and atherosclerosis. This study aimed to evaluate the relationship between serum A-FABP levels and carotid-femoral pulse wave velocity (cfPWV) in peritoneal dialysis (PD) patients. Methods. This study obtained fasting blood samples from 76 PD patients. A validated tonometry system was used to measure cfPWV. Patients with cfPWV values >10 m/s were classified into the high arterial stiffness group, whereas patients with values ≤10 m/s were classified into the low arterial stiffness group, according to the ESH-ESC 2013 guidelines. Serum A-FABP levels were measured using a commercial enzyme-linked immunosorbent assay kit. Results. Twenty-five (32.9%) of the 76 PD patients were classified in the high arterial stiffness group. Compared with the patients in the low arterial stiffness group, the high arterial stiffness group was older ( P = 0.002) and had a longer PD vintage ( P = 0.011), higher diastolic blood pressure (DBP, P = 0.036), higher fasting glucose levels ( P = 0.012), higher serum C reactive protein levels ( P = 0.001), and higher serum A-FABP levels ( P < 0.001). A multivariate logistic regression analysis of the factors significantly associated with central arterial stiffness revealed that A-FABP (odds ratio (OR): 1.165, 95% confidence interval (CI): 1.056–1.284, P = 0.002), age (OR: 1.423, 95% CI: 1.153–1.757, P = 0.001), PD vintage (OR: 1.049, 95% CI: 1.015–1.085, P = 0.005), and DBP (OR: 1.152, 95% CI: 1.033–1.285, P = 0.011) were independent predictors of central arterial stiffness in PD patients. Furthermore, serum A-FABP levels (β = 0.476, adjusted R2 change: 0.197, P < 0.001) were significantly positively correlated with cfPWV according to the multivariable forward stepwise linear regression analysis. Conclusions. A-FABP levels are an independent marker of central arterial stiffness in PD patients.

show abstract

“…were measured in light clothing without shoes (adjusted to nearest 0.5 kg and 0.5 cm, respectively), and body mass index (BMI) was calculated using Quetelet's formula (weight (kg)/ height (m 2 )) [16,20,21].…”

Section: Anthropometric Analysis Patient Weight and Heightmentioning

confidence: 99%

“…After an 8 h overnight fasting, approximately 5 mL blood was sampled from all participants and immediately centrifuged at 3000 g for 10 min. Serum blood urea nitrogen (BUN), creatinine, fasting glucose, TG, total cholesterol (TCH), HDL-C, LDL-C, and C-reactive protein (CRP) levels were determined using an autoanalyzer (COBAS Integra 800, Roche Diagnostics, Basel, Switzerland) [16,20,21]. Serum ANGPTL3 (R&D Systems, Inc., Minneapolis, MN) levels were quantified using the commercial enzyme-linked immunosorbent assay [16].…”

Section: Biochemical Investigationsmentioning

confidence: 99%

High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

Chen

Hsu

Lee

et al. 2020

International Journal of Hypertension

Self Cite

View full text Add to dashboard Cite

Background. Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether ANGPTL3 levels can be used to predict the future occurrence of major adverse cardiovascular events (MACEs) in patients with CAD. Methods. Overall, 90 patients with CAD were enrolled between January and December 2012. The study’s primary endpoint was incidence of MACEs. Patient follow-up was completed on June 30, 2017. Results. Following a median follow-up period of 54 months, 33 MACEs had occurred. Patients reporting MACEs had lower statin use (P=0.022) and higher serum C-reactive protein (P<0.001) and serum ANGPTL3 (P<0.001) levels than those without MACEs. Kaplan–Meier analysis revealed higher cumulative incidence of CV events in the high ANGPTL3 group (median ANGPTL3 level ≥ 222.37 ng/mL) than in the low ANGPTL3 group (log-rank P=0.046). Multivariable Cox regression analysis demonstrated that ANGPTL3 levels were independently associated with MACEs in patients with CAD (hazard ratio: 1.003; 95% confidence interval: 1.000–1.005; P=0.026) after adjusted for age, gender, and body mass index, classical risk factors, and potential confounders. Conclusions. Serum ANGPTL3 levels could serve as a biomarker for future occurrence of MACEs in patients with CAD.

show abstract

High Levels of Serum Adipocyte Fatty Acid-binding Protein Predict Cardiovascular Events in Coronary Artery Disease Patients

Cited by 9 publications

References 32 publications

Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients

Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients

Positive Associations between Adipocyte Fatty Acid-Binding Protein Level and Central Arterial Stiffness in Peritoneal Dialysis Patients

High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease

Contact Info

Product

Resources

About