2012
DOI: 10.3382/ps.2011-01914
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High levels of vitamin E affect retinol binding protein but not CYP26A1 in liver and hepatocytes from laying hens

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Cited by 11 publications
(3 citation statements)
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“…In addition, the excessive intake of α-tocopherol could contribute to the inhibition of retinol-binding protein synthesis but not on CYP26A1. Zhou et al [ 33 ] reported that dietary 320 and 1280 IU/kg of α-tocopherol in vivo and 100 uM of α-tocopherol in hepatocytes in vitro inhibited retinol-binding protein synthesis. Still, α-tocopherol supplementation did not affect the regulation of the CYP26A1 gene in the liver and hepatocytes.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the excessive intake of α-tocopherol could contribute to the inhibition of retinol-binding protein synthesis but not on CYP26A1. Zhou et al [ 33 ] reported that dietary 320 and 1280 IU/kg of α-tocopherol in vivo and 100 uM of α-tocopherol in hepatocytes in vitro inhibited retinol-binding protein synthesis. Still, α-tocopherol supplementation did not affect the regulation of the CYP26A1 gene in the liver and hepatocytes.…”
Section: Discussionmentioning
confidence: 99%
“…A total of 36 birds were used for the in vitro experiments. Primary hepatocytes were isolated from 2 Rohman layers each time according to the methods described previously ( Zhou et al, 2012 ; Qi et al, 2018 ). The hepatocytes were resuspended in William's medium E (Sigma, Shanghai, China) and plated into 6-well plates (2 × 10 6 cells/well) after cell counting.…”
Section: Methodsmentioning
confidence: 99%
“…Primary hepatocytes were isolated from the Rohman layers according to the methods described by [43,44]. The hepatocytes were resuspended in William's medium E (Sigma, Shanghai, China) and plated into 6-well plates (2 × 10 6 cells/well) after cell counting.…”
Section: Cell Culture and Treatmentmentioning
confidence: 99%