High local recurrence of early-stage hepatocellular carcinoma after percutaneous thermal ablation in routine clinical practice

Chinnaratha, Mohamed Asif; Sathananthan, Dharshan; Pateria, Puraskar; Tse, Edmund; MacQuillan, Gerry; Mosel, Leigh; Pathi, Ramon; Madigan, D.G.; Wigg, Alan

doi:10.1097/meg.0000000000000270

Cited by 30 publications

(31 citation statements)

References 28 publications

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“…For HCC of 2 cm or smaller, the 5-year LTP rates were reported to be 10%–15.9% after RFA [11, 17, 24]. In our study, no significant difference was observed between the two groups in the LTP rate: 9.6% in the MWA group and 10.1% in the RFA group.…”

Section: Discussioncontrasting

confidence: 60%

Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma

Shen

Wang

et al. 2017

Chin J Cancer

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BackgroundPercutaneous radiofrequency ablation (RFA) is a first-line treatment for very-early-stage hepatocellular carcinoma (HCC), whereas the efficacy of percutaneous microwave ablation (MWA) for very-early-stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very-early-stage HCC.MethodsClinical data of 460 patients who were diagnosed with very-early-stage HCC and treated with percutaneous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, in Shanghai, China were retrospectively analyzed. Of these 460 patients, 159 received RFA, 301 received MWA. Overall survival (OS), recurrence-free survival (RFS), local tumor progression (LTP), complete ablation, and complication occurrence rates were compared between the two groups, and the prognostic factors associated with survival were analyzed.ResultsNo significant differences were observed between the two groups in terms of the 1-, 3-, or 5-year OS rates (99.3%, 90.4%, and 78.3% for MWA vs. 98.7%, 86.8%, and 73.3% for RFA, respectively; P = 0.331). Furthermore, no significant differences were observed between the two groups in terms of the corresponding RFS rates (94.4%, 71.8%, and 46.9% for MWA vs. 89.9%, 67.3%, and 54.9% for RFA, respectively; P = 0.309), the LTP rates (9.6% vs. 10.1%, P = 0.883), the complete ablation rates (98.3% vs. 98.1%, P = 0.860), or the occurrence rates of major complications (0.7% vs. 0.6%, P = 0.691). By multivariate analysis, LTP, antiviral therapy, and treatment of recurrence were independent risk factors for OS (P < 0.001), and the alpha-fetoprotein level was an independent prognostic factor for RFS (P = 0.002).ConclusionsMWA is as safe and effective as RFA in treating very-early-stage HCC, supporting MWA as a first-line treatment option for this disease.

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Section: Discussioncontrasting

confidence: 60%

Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma

Shen

Wang

et al. 2017

Chin J Cancer

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“…This has since been published as a full-text article. 28 Thus, a total of 10 studies were included in the final meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Percutaneous thermal ablation for primary hepatocellular carcinoma: A systematic review and meta‐analysis

Chinnaratha

Chuang

Fraser

et al. 2016

J of Gastro and Hepatol

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“…A number of investigations have confirmed that poor differentiation and microvascular invasion were related to poor outcomes for patients with HCC after liver resection or RFA. [2][3][4] Moreover, cirrhosis is proposed as a risk factor for late HCC recurrence by many investigations. 2 We suggested how many patients had cirrhosis in each group should be clarified in this study.…”

mentioning

confidence: 99%

“…The local recurrence rate of patients with very early stage HCC was 15.9% in Chinnaratha et al's study, which was similar to the current study. 1,3 RFA can be carried out percutaneously, laparoscopically, or as an open surgery. However, some investigators suggested open surgical ablation was superior to percutaneous ablation for patients with liver cancer.…”

mentioning

confidence: 99%

Does Surgical Resection Provide Better Outcomes Than Radiofrequency Ablation in Patients With BCLC Very Early-stage Hepatocellular Carcinoma?

Wen²

2017

Annals of Surgery

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High local recurrence of early-stage hepatocellular carcinoma after percutaneous thermal ablation in routine clinical practice

Cited by 30 publications

References 28 publications

Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma

Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma

Percutaneous thermal ablation for primary hepatocellular carcinoma: A systematic review and meta‐analysis

Does Surgical Resection Provide Better Outcomes Than Radiofrequency Ablation in Patients With BCLC Very Early-stage Hepatocellular Carcinoma?

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