High-magnetic-field electromagnetophoresis of micro-particles in a capillary flow system

Iiguni, Yoshinori; Suwa, Masayori; Watarai, Hitoshi

doi:10.1016/j.chroma.2003.10.134

Cited by 33 publications

(27 citation statements)

References 14 publications

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“…(1)) and the viscous force, represented by Stokes equation. 5,6 Once a particle reached to the wall, it stayed there, as long as the electric current was applied.…”

Section: Droplet Behavior In Bulk Superconducting Magnet Systemmentioning

confidence: 99%

“…2,3 We have applied the electromagnetophoretic force, mainly the electromagnetic buoyancy, to the separation of microparticles in silica capillary systems. [4][5][6] Furthermore, an electromagnetophoretic force was applied to dynamic force measurements of chemical interactions between a particle and a capillary wall and a dynamic force analysis of the breaking of interactions between a yeast cell and lectin on the wall of a capillary. [7][8][9][10] The advantages of using an electromagnetophoretic force for the separation of particles and the dynamic force measurement are that: (i) a non-contact migration of particles is possible, (ii) an open solution system is acceptable, and (iii) the separation force is easily controllable by an electric current.…”

Section: Introductionmentioning

confidence: 99%

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Electromagnetophoretic Micro-convection around a Droplet in a Capillary

2017

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The electromagnetophoretic behavior of organic droplets in an electrolyte solution was investigated in a silica capillary cell using a superconducting bulk magnet (3.5 T) and a magnetic circuit (2.7 T). The initially dispersed emulsion droplets of dodecane migrated to the wall of the capillary, responding to the direction of an electric current, and coalesced to form smaller and larger droplets after some repeated migrations. When the electric current was applied continuously, the larger droplets became arranged with regular intervals on the wall, and smaller droplets rotated around the larger droplets. These interesting behaviors were analyzed while taking into account the local electric current density determined by the flow velocity of the ionic current around a droplet, which was lowest on the electrode sides of the droplet. The difference in the local electric current density generated the Lorentz-force difference in the medium, which lead to local microconvection around the droplet, and also the alignment of larger droplets by a repelling effect between the adjacent microconvections.

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“…(1)) and the viscous force, represented by Stokes equation. 5,6 Once a particle reached to the wall, it stayed there, as long as the electric current was applied.…”

Section: Droplet Behavior In Bulk Superconducting Magnet Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electromagnetophoretic Micro-convection around a Droplet in a Capillary

2017

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“…Consequently, the microparticles migrate in the opposite direction of the Lorentz force. 22,30 A schematic of the principle of particle separation using microchip EMP is shown in Fig. 1.…”

Section: Principle Of Separation By Microchip Electromagnetophoresismentioning

confidence: 99%

“…30 Equation (1) indicates that the electromagnetophoretic velocity of particles depends on their size and apparent conductivity, and is proportional to the magnetic flux density and the applied current. Hence, with a constant magnetic field produced by a permanent magnet, particles can be separated based on their size and conductivity by adjusting the applied current.…”

Section: Principle Of Separation By Microchip Electromagnetophoresismentioning

confidence: 99%

“…The apparent conductivities of polystyrene particles and yeast cells in 1 M KCl solution were 0.019 and 0.075 S cm -1 , respectively. 27,30 The separation medium was 0.155 M KCl solution, which had an ionic strength nearly equal to an isotonic solution used for the study of biological cells, containing 20% urea in order to match the densities of the polystyrene particles and the solution to prevent the sedimentation of the particles. Moreover, the flow rate was increased by three times for increasing the throughput; the flow rate from inlet 1 and 2 were 3.99 and 16.01 μL h -1 , respectively.…”

Section: Separation Between Heterogeneous Particles By Microchip Elecmentioning

confidence: 99%

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Continuous-flow Size-based Separation of Microparticles by Microchip Electromagnetophoresis

et al. 2015

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A novel microchip separation method for microparticles based on electromagnetophoresis was developed. In this method, a double Y-shape microchip with two inlets and two outlets was used for particle separation. Microparticles of two different sizes were suspended in an aqueous solution and introduced into the microchannel from one inlet with a stream of the aqueous solution without particles from another inlet by a hydrodynamic flow. Then, the particles with two different sizes were migrated orthogonal to the flow by elctromagnetophoresis and separated to different outlets based on the difference in their electromagnetophoric velocities, which depended on the size of particle. Using this method, at one outlet, 89% of 3 μm polystyrene latex particles were isolated from a mixture of 3 and 10 μm particles. By combining hydrodynamic focusing, both 3 and 10 μm particles were recovered at the different outlets with 100% purity and recovery, respectively. Even the separation of 3 and 6 μm particles was also achieved with about 98% recovery and purity. Moreover, yeast cells and polystyrene particles could be separated with high separation efficiency by this technique.

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Label‐Free Microfluidic Manipulation of Particles and Cells in Magnetic Liquids

Zhao

Cheng

Miller

et al. 2016

Adv Funct Materials

133

125

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Manipulating particles and cells in magnetic liquids through so-called “negative magnetophoresis” is a new research field. It has resulted in label-free and low-cost manipulation techniques in microfluidic systems and many exciting applications. It is the goal of this review to introduce the fundamental principles of negative magnetophoresis and its recent applications in microfluidic manipulation of particles and cells. We will first discuss the theoretical background of three commonly used specificities of manipulation in magnetic liquids, which include the size, density and magnetic property of particles and cells. We will then review and compare the media used in negative magnetophoresis, which include paramagnetic salt solutions and ferrofluids. Afterwards, we will focus on reviewing existing microfluidic applications of negative magnetophoresis, including separation, focusing, trapping and concentration of particles and cells, determination of cell density, measurement of particles' magnetic susceptibility, and others. We will also examine the need for developing biocompatible magnetic liquids for live cell manipulation and analysis, and its recent progress. Finally, we will conclude this review with a brief outlook for this exciting research field.

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High-magnetic-field electromagnetophoresis of micro-particles in a capillary flow system

Cited by 33 publications

References 14 publications

Electromagnetophoretic Micro-convection around a Droplet in a Capillary

Electromagnetophoretic Micro-convection around a Droplet in a Capillary

Continuous-flow Size-based Separation of Microparticles by Microchip Electromagnetophoresis

Label‐Free Microfluidic Manipulation of Particles and Cells in Magnetic Liquids

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