High-magnification chromoscopic colonoscopy in ulcerative colitis: a valid tool for in vivo optical biopsy and assessment of disease extent

Hurlstone, David P.; Sanders, DS; McAlindon, Mark E.; Thomson, Mike; Cross, Simon S.

doi:10.1055/s-2006-944732

Cited by 46 publications

(41 citation statements)

References 10 publications

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“…Hence, target biopsies of suspicious lesions might provide more effective surveillance than taking random biopsies. [28][29][30] Hurlstone et al 31,32 reported on the efficacy of magnifying colonoscopy in UC using ''optical biopsy'' for the surveillance of colitic cancer and disease extent. Nishizawa et al 33 first reported the healing process patterns of UC mucosa using the feature of magnifying colonoscopy.…”

Section: Histological Findingsmentioning

confidence: 99%

Magnifying colonoscopy used to predict disease relapse in patients with quiescent ulcerative colitis

Watanabe

Sumioka

Hiramoto

et al. 2009

Inflammatory Bowel Diseases

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Section: Histological Findingsmentioning

confidence: 99%

Magnifying colonoscopy used to predict disease relapse in patients with quiescent ulcerative colitis

Watanabe

Sumioka

Hiramoto

et al. 2009

Inflammatory Bowel Diseases

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“…Mucosal lesions can be characterized by the Pit Pattern Classification [10] . The largest prospective study compared conventional endoscopy with magnification endoscopy in 300 patients with UC and found a high correlation of magnification with disease activity and histopathological grading [11] . It seems to be of high diagnostic relevance to combine chromoendoscopy with magnification.…”

Section: Magnification Endoscopymentioning

confidence: 99%

Malignant Transformation in Inflammatory Bowel Disease: Prevention, Surveillance and Treatment – New Techniques in Endoscopy

Bojarski¹

2009

Dig Dis

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Patients with a long-standing history of ulcerative colitis (UC) or Crohn’s disease (CD) with a history of inflammation in the colon have a risk for the development of colon cancer. To these patients at least one colonoscopy per year should be offered according to national surveillance guidelines in patients with inflammatory bowel disease (IBD). Following general recommendations, surveillance colonoscopy should be performed without disease activity and four tissue samples each 10 cm should be taken. Beside high-resolution videoendoscopy and magnification endoscopy, the application of dyes applied via a spraying catheter are of additional diagnostic value with a factor 3–4 higher detection rate of intraepithelial neoplasia (IEN). It is under current evaluation if the use of computerized virtual chromoendoscopy techniques (NBI, FICE, High Line/HD+) has the same diagnostic output compared to classical spraying techniques. The detection rate of IEN can be further improved by using newly developed in-vivo histology techniques. A combination of chromoendoscopy with confocal endomicroscopy (CEM) can detect 5-fold higher rates of IEN compared with random biopsy protocols. An alternative technique to CEM is the miniprobe-based CEM. Autofluorescence imaging is an interesting approach for the surveillance of IBD patients with first clinical data published.

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“…A laborious protocol has been proposed involving not only target biopsies from suspicious lesions, but also two to four random biopsies taken every 10 cm of the colon [32] . MCC has emerged as the best method currently available for identifying dysplastic lesions in an inflammatory bowel disease setting [33,34] . In ter ms of NBI research, the limitations of the first NBI prototype were recently shown in a prospective randomized crossover study of 42 patients with longstanding ulcerative colitis.…”

Section: Detection Of Dysplastic Areas In Ulcerative Colitismentioning

confidence: 99%

Narrow-band imaging optical chromocolonoscopy: Advantages and limitations

Emura¹,

Saito²,

Ikematsu³

2008

WJG

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Narrow-band imaging (NBI) is an innovative optical technology that modifies the center wavelength and bandwidth of an endoscope's light into narrow-band illumination of 415 ± 30 nm. NBI markedly improves capillary pattern contrast and is an in vivo method for visualizing microvessel morphological changes in superficial neoplastic lesions. The scientific basis for NBI is that short wavelength light falls within the hemoglobin absorption band, thereby facilitating clearer visualization of vascular structures. Several studies have reported advantages and limitations of NBI colonoscopy in the colorectum. One difficulty in evaluating results, however, has been nonstandardization of NBI systems (Sequential and nonsequential). Utilization of NBI technology has been increasing worldwide, but accurate pit pattern analysis and sufficient skill in magnifying colonoscopy are basic fundamentals required for proficiency in NBI diagnosis of colorectal lesions. Modern optical technology without proper image interpretation wastes resources, confuses untrained endoscopists and delays interinstitutional validation studies. Training in the principles of "optical image-enhanced endoscopy" is needed to close the gap between technological advancements and their clinical usefulness. Currently available evidence indicates that NBI constitutes an effective and reliable alternative to chromocolonoscopy for in vivo visualization of vascular structures, but further study assessing reproducibility and effectiveness in the colorectum is ongoing at various medical centers.

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High-magnification chromoscopic colonoscopy in ulcerative colitis: a valid tool for in vivo optical biopsy and assessment of disease extent

Cited by 46 publications

References 10 publications

Magnifying colonoscopy used to predict disease relapse in patients with quiescent ulcerative colitis

Magnifying colonoscopy used to predict disease relapse in patients with quiescent ulcerative colitis

Malignant Transformation in Inflammatory Bowel Disease: Prevention, Surveillance and Treatment – New Techniques in Endoscopy

Narrow-band imaging optical chromocolonoscopy: Advantages and limitations

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