High-mechanical strength carboxymethyl chitosan-based hydrogel film for antibacterial wound dressing

Zhang, Min; Yang, Ming‐Bo; Woo, Meng Wai; Li, Yanchun; Han, Wei; Dang, Xugang

doi:10.1016/j.carbpol.2020.117590

Cited by 163 publications

(60 citation statements)

References 50 publications

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“…Carboxymethyl chitosan (CMCS) is a derivative of chitosan and functionalized with active groups, including hydroxyl, carboxyl, and amino groups. It is widely used for food preservation, biomedicine, and cosmetics, due to its biodegradability and biocompatibility. − In addition, the surface functionalization opens more potential applications in polymer composites.…”

Section: Introductionmentioning

confidence: 99%

Fully Biobased Elastomer Composites with Mechanically Robust, Reprocessable, and Biocompatible Properties

Zhao

Yang

Dong

et al. 2021

ACS Appl. Polym. Mater.

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It is of importance, though difficult, to integrate reinforcement, functionalization, and recyclability into elastomeric materials. Here we describe a biomass-derived epoxidized natural rubber (ENR) cross-linked with dynamic covalent bonds and reinforced with functional carboxymethyl chitosan (CMCS). The ENR/CMCS composites show enhanced mechanical properties and thermal stability, due to the uniform dispersion of the CMCS fillers and strong interfacial interaction between the ENR matrix and fillers. These cross-linked rubbers can undergo topological network rearrangements through dynamic exchange reactions, endowing the materials with reprocessability and recyclability. Due to the biologically derived and green features of the both polymeric matrix and filler, the fully biobased ENR/CMCS composites also show excellent biocompatibility, which will expand their application in the field of biomaterials.

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Section: Introductionmentioning

confidence: 99%

Fully Biobased Elastomer Composites with Mechanically Robust, Reprocessable, and Biocompatible Properties

Zhao

Yang

Dong

et al. 2021

ACS Appl. Polym. Mater.

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“…The antibacterial ability of chitosan quaternary ammonium salt film and cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate hydrogel films was determined using the zone of inhibition method [ 39 ]. Firstly, the autoclaved bacterial nutrient agar media was prepared.…”

Section: Methodsmentioning

confidence: 99%

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Zhang

Xiao-rui

et al. 2021

Marine Drugs

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Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

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“…When applied to burns, textile wound dressings adhere to the wound site in an uncontrollable manner, making its removal painful as the superficial layer of the wound bed is stripped in the process [ 1 , 22 ]. The ultimate wound dressings should be flexible [ 13 ], have antibacterial or at least bacteriostatic activity [ 21 ], exhibit adequate exudate absorption and gas permeability [ 13 ], allow a pain-free removal for the greater comfort possible, and be biocompatible [ 22 , 23 , 24 , 25 ]. The biocompatibility of a material is ascertained after an extensive array of tests that study the physical, chemical, and mechanical properties of the material as well as the potential adverse effects (i.e., allergenic, mutagenic, and cytotoxic) that may occur from its use, being crucial that the material does not elicit substantial damages or toxic effects to the body [ 26 ].…”

Section: Introduction—how Wound Care Is Still Relevant Nowadaysmentioning

confidence: 99%

Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications

2022

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Despite the noticeable evolution in wound treatment over the centuries, a functional material that promotes correct and swift wound healing is important, considering the relative weight of chronic wounds in healthcare. Difficult to heal in a fashionable time, chronic wounds are more prone to infections and complications thereof. Nitric oxide (NO) has been explored for wound healing applications due to its appealing properties, which in the wound healing context include vasodilation, angiogenesis promotion, cell proliferation, and antimicrobial activity. NO delivery is facilitated by molecules that release NO when prompted, whose stability is ensured using carriers. Hydrogels, popular materials for wound dressings, have been studied as scaffolds for NO storage and delivery, showing promising results such as enhanced wound healing, controlled and sustained NO release, and bactericidal properties. Systems reported so far regarding NO delivery by hydrogels are reviewed.

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High-mechanical strength carboxymethyl chitosan-based hydrogel film for antibacterial wound dressing

Cited by 163 publications

References 50 publications

Fully Biobased Elastomer Composites with Mechanically Robust, Reprocessable, and Biocompatible Properties

Fully Biobased Elastomer Composites with Mechanically Robust, Reprocessable, and Biocompatible Properties

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications

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