2000
DOI: 10.1128/jvi.74.22.10523-10534.2000
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High-Mobility-Group Protein I Can Modulate Binding of Transcription Factors to the U5 Region of the Human Immunodeficiency Virus Type 1 Proviral Promoter

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Cited by 32 publications
(33 citation statements)
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“…There are three members in the highmobility group protein family: HMG I, HMG Y, and HMG I-C (3). It has been shown previously that HMG I modulates the binding of transcription factors to the LTR of HIV (22). It is possible that HMG I-C also functions as a regulator of HIV-MLV transcription.…”
Section: Discussionmentioning
confidence: 99%
“…There are three members in the highmobility group protein family: HMG I, HMG Y, and HMG I-C (3). It has been shown previously that HMG I modulates the binding of transcription factors to the LTR of HIV (22). It is possible that HMG I-C also functions as a regulator of HIV-MLV transcription.…”
Section: Discussionmentioning
confidence: 99%
“…23,2003 THE HPV18 ENHANCEOSOME CONTAINS HMG-I(Y) AND CBP/p300 2331 for example, are composed of stretches of AT-rich sequences that may play a structural role. On the other hand, we demonstrated by point mutations that the Oct binding site, contained within footprint X, is an important sequence and may account for the decrease in transcriptional activity exhibited by fragment C (data not shown).…”
Section: Resultsmentioning
confidence: 99%
“…Indeed, architectural factors, either from the HMG family, or not (LEF-1 for example), produce topological changes in the DNA (21,52,56) and even looped structures, as shown for the ␤-globin promoter (6). In addition, HMG-I(Y) has been shown to increase binding affinities of several transcription factors (28,31,23,40,56), and we can therefore speculate that it plays such a role in the HPV18 enhanceosome, although more work is needed to determine the other factors involved.…”
Section: Discussionmentioning
confidence: 99%
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“…Transfection was performed by using calcium phosphate, and cells were treated with 40 mM chloroquine for 3 h. Cells were induced and harvested 72 h after transfection, and nuclear extracts were prepared as previously described (21). Recombinant His-tagged ATF-1 and ATF-3 were purified with Ni-nitrilotriacetic acid resin (QIAGEN) according to the method of Thanos and Maniatis (39).…”
Section: Methodsmentioning
confidence: 99%