High mortality of cocaine-related ischemic colitis: a hybrid cohort/case-control study

Elramah, Moshen; Einstein, Michael; Mori, Naoyo; Vakil, Nimish

doi:10.1016/j.gie.2012.02.016

Cited by 32 publications

(38 citation statements)

References 6 publications

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“…Little is known about the effect of ethnic and socioeconomic status on the development of ischemic colitis. In our study, most patients were Caucasians; however, a predilection of non‐Caucasian ethnics has been described in a subgroup of patients with ischemic colitis who abuse cocaine . Ischemic colitis is also known as the disease of the elderly, which is consistent with our patient population (mean age 69.4 years).…”

Section: Discussionsupporting

confidence: 88%

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Sherid

Sifuentes

Samo

et al. 2014

J of Digest Diseases

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Section: Discussionsupporting

confidence: 88%

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Sherid

Sifuentes

Samo

et al. 2014

J of Digest Diseases

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“…The most common nonvascular radiologic findings in ischemic colitis are colonic wall thickening and pericolonic fat stranding [22, 24, 28, 29]. The mean colonic wall thickness in ischemic colitis is 8-9 mm which ranges from 2 to 20 mm [22, 30].…”

Section: Discussionmentioning

confidence: 99%

“…In another study of 54 patients with ischemic colitis, 6 patients (11.1%) had angiographic studies which were normal except in one case (16.7%) which showed severe stenosis in the IMA associated with arteriosclerotic disease [22]. In a third study of 97 patients of ischemic colitis, angiography was performed in 9 patients (9.3%) and revealed a stenosis in the SMA in only one patient (11.1%) [29]. It was not documented in these three studies whether the angiographic studies were conventional angiogram, CT angiogram, or both.…”

Section: Discussionmentioning

confidence: 99%

Is CT Angiogram of the Abdominal Vessels Needed following the Diagnosis of Ischemic Colitis? A Multicenter Community Study

Sherid

Samo

Sulaiman

et al. 2014

ISRN Gastroenterology

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Background. CT angiogram is frequently obtained after diagnosis of ischemic colitis (IC). Aims. To investigate the vascular findings of CT angiogram as compared to contrast-enhanced CT scan and whether this modality changes the management or prognosis of IC. Methods. We conducted a retrospective analysis of patients with IC from 2007 to 2013. Results. CT angiogram was performed in 34 patients (28.81%), whereas contrast-enhanced CT scan was performed in 54 patients (45.76%). In CT angiogram group, 8 patients (23.5%) had atherosclerotic changes. Stenosis was found in 12 patients (35.3%) (9: celiac trunk, 3: SMA). Among this group, one patient underwent colectomy and another underwent angioplasty of the celiac trunk who died within 30 days. Among contrast-enhanced CT scan group, 5 patients (9.3%) had atherosclerotic changes. Stenosis was found in 5 patients (9.3%) (3: celiac trunk, 1: SMA, and 1: IMA). Among this group, 3 patients had colectomy and one died within 30 days. There was no statistical difference between both groups in all vascular findings except the stenosis which was higher in CT angiogram group (P = 0.0025). Neither the need for surgery nor all-cause mortality was different between both groups. Conclusion. CT angiogram did not provide any useful findings that altered the management or the prognosis of IC.

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“…) and recreational drug abuse (Elramah et al . ). For example during exercise, splanchnic vasoconstriction rapidly redistributes blood to where it is required in the lungs, muscle and skin (Perko et al .…”

Section: Introductionmentioning

confidence: 97%

“…) and recreational drugs, such as cocaine (Elramah et al . ). A deficit in O 2 availability is thought to be a major risk factor in the development of NEC, which is the most frequent life‐threatening GI emergency of neonatal intensive care units (Kafetzis et al .…”

Section: Introductionmentioning

confidence: 97%

Oxygen in the regulation of intestinal epithelial transport

Ward

Keely

2014

The Journal of Physiology

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The transport of fluid, nutrients and electrolytes to and from the intestinal lumen is a primary function of epithelial cells. Normally, the intestine absorbs approximately 9 l of fluid and 1 kg of nutrients daily, driven by epithelial transport processes that consume large amounts of cellular energy and O 2 . The epithelium exists at the interface of the richly vascularised mucosa, and the anoxic luminal environment and this steep O 2 gradient play a key role in determining the expression pattern of proteins involved in fluid, nutrient and electrolyte transport. However, the dynamic nature of the splanchnic circulation necessitates that the epithelium can evoke co-ordinated responses to fluctuations in O 2 availability, which occur either as a part of the normal digestive process or as a consequence of several pathophysiological conditions. While it is known that hypoxia-responsive signals, such as reactive oxygen species, AMP-activated kinase, hypoxia-inducible factors, and prolyl hydroxylases are all important in regulating epithelial responses to altered O 2 supply, our understanding of the molecular mechanisms involved is still limited. Here, we aim to review the current literature regarding the role that O 2 plays in regulating intestinal transport processes and to highlight areas of research that still need to be addressed.

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High mortality of cocaine-related ischemic colitis: a hybrid cohort/case-control study

Cited by 32 publications

References 6 publications

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Ischemic colitis: A forgotten entity. Results of a retrospective study in 118 patients

Is CT Angiogram of the Abdominal Vessels Needed following the Diagnosis of Ischemic Colitis? A Multicenter Community Study

Oxygen in the regulation of intestinal epithelial transport

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