High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

Li, Han; Lu, Xiangxue; Xiong, Ruifang; Wang, Shixiang

doi:10.1155/2017/9327136

Cited by 66 publications

(68 citation statements)

References 44 publications

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“…In patients on prevalent hemodialysis, NLR was also associated with all-cause mortality [25]. We recently reported that NLR was also associated with allcause and cardiovascular mortality in patients on hemodialysis [26]. NLR was found to be an independent predictor of left atrium mechanical function and atrial electromechanical delay times in patients with ESRD receiving peritoneal dialysis or hemodialysis [27].…”

Section: Discussionmentioning

confidence: 98%

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

Wang

Zhang

et al. 2018

Kidney Blood Press Res

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Background/Aims: Chronic inflammation is associated with increased risk of cardiovascular death in patients with end-stage renal disease (ESRD). Although elevated neutrophil-tolymphocyte ratio (NLR), a novel inflammatory marker, has been shown to predict cardiovascular disease and all-cause mortality in the general population, limited evidence is available for its role in ESRD. Methods: We enrolled 86 patients undergoing peritoneal dialysis (PD) for a 36-month follow-up to investigate the association between the NLR and arterial stiffness markers, namely, carotid-femoral pulse wave velocity (cfPWV) and carotid augmentation index (AIx), and mortality in PD patients. The primary endpoints were cardiovascular mortality and all-cause mortality. Kaplan-Meier curves were used to show the cumulative incidence of cardiovascular mortality and all-cause mortality. Results: High NLR was found to be a predictor of increased cfPWV (β = 1.150; P < 0.001) and AIx (β = 3.945; P < 0.001) in patients on PD. Patients with higher NLR had lower survival during follow-up. Kaplan-Meier curves showed that the cumulative incidences of both cardiovascular mortality and all-cause mortality were significantly higher in patients with NLR ≥ 4.5 (both P < 0.01). Conclusion: Our results suggest that high NLR is independently associated with arterial stiffness and predicts cardiovascular and all-cause mortality in PD patients.

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Section: Discussionmentioning

confidence: 98%

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

Wang

Zhang

et al. 2018

Kidney Blood Press Res

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“…The increased NLR values are associated with poor outcomes for various types of cancers, including colorectal cancer, esophageal cancer, gastric cancer, non‐small‐cell lung cancer, ovarian cancer, and pancreatic cancer . Importantly, It has been reported that the NLR value was an independent prognostic parameter in cardiovascular disease, nodular sclerosis Hodgkin lymphoma, bladder cancer, advanced pancreatic cancer . Moreover, the elevated NLR value has been shown to correlate with worse prognosis in patients with HCC who underwent transcatheter arterial chemoembolization, radiofrequency, resection, or liver transplantation .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of neutrophil‐to‐lymphocyte ratio associated with prognosis in HBV‐infected patients

Gong

Liang

Zhou

et al. 2018

Journal of Medical Virology

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Chronic severe hepatitis B (CSHB) is a critical clinical syndrome with a high mortality rate in China. The prognostic value of neutrophil to lymphocyte ratio (NLR) which is simple, low-cost, and useful inflammatory marker for hepatitis B virus (HBV)-infected patients is largely overlooked and without further exploration. This study assesses the association of NLR with prognosis of chronic hepatitis B (CHB) and CSHB patients. Two hundred and eighty subjects, including 79 with chronic hepatitis B (CHB) and 67 with chronic severe hepatitis B (CSHB), and 134 healthy individuals were retrospectively recruited into this study. Blood samples were collected to conduct liver function, prothrombin time activity (PTA), international normalized ratio (INR), HBV DNA measurement, and routine hematological testing. All patients were followed up for at least 3 months. NLR values in patients with CSHB (4.984 ± 3.608) and CHB (2.020 ± 1.182) were significantly higher than those in healthy control (1.638 ± 0.601) and patients with CSHB had the highest NLR values than CHB and healthy control. Increased NLR values were clinically associated with severe liver disease and higher mortality rate. NLR was found to be an independent predictor of mortality in multivariable Cox Regression models (HR = 3.912, 95%CI: 1.587-9.640, P = 0.003). NLR values are significantly increased in CHB and CSHB patients with the severity of liver disease. Moreover, NLR value is an independent predicting factor for the mortality rate in HBV-infected patients.

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“…Li et al showed that high neutrophil/ lymphocyte ratio can predict cardiovascular mortality in chronic hemodialysis patients [31]. The dialysis duration in their study was not correlated with cardiovascular mortality (correlation coefficient = 0.055, P = 0.369).…”

Section: Discussionmentioning

confidence: 76%

“…In another study by Losito et al demonstrated that dialysis duration was one of the predictor of cardiovascular mortality. But the OR was borderline (OR: 1.002, 95% CI: 1.001 -1.004, P = 0.006) [31]. The controversy might be due to not enough duration of follow up and other confounding factors which were correlated with dialysis duration and masked its impact on cardiovascular mortality.…”

Section: Discussionmentioning

confidence: 97%

Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients

Weng

Yen

et al. 2018

Kidney Blood Press Res

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Background/Aims: Uremic pruritus (UP) is an unpleasant complication in patients undergoing maintenance dialysis. Cardiovascular and infection related deaths are the major causes of mortality in patients undergoing dialysis. Studies on the correlation between cardiovascular or infection related mortality and UP are limited. Methods: We analyze 866 maintenance hemodialysis (MHD) patients in our hemodialysis centers. Clinical parameters and 24-month cardiovascular and infection-related mortality are recorded. Results: The associations between all-cause, cardiovascular and infection related mortality with clinical data including UP are analyzed. Multivariate Cox regression demonstrated that UP is a significantly predictor for 24-month cardiovascular mortality in the MHD patients (Hazard ratio: 3.164; 95% confidence interval, 1.743–5.744; p < 0.001). Conclusion: Uremic pruritus is one of the predictor of 24-month cardiovascular mortality in MHD patients.

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High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

Cited by 66 publications

References 44 publications

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

Prognostic value of neutrophil‐to‐lymphocyte ratio associated with prognosis in HBV‐infected patients

Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients

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