High‐normal urinary albumin‐to‐creatinine ratio is independently associated with metabolic syndrome in <scp>C</scp>hinese patients with type 2 diabetes mellitus: A cross‐sectional community‐based study

Li, Meifang; Feng, Qi; Tu, Ya; Zhang, Rong; Dong, Xuehong; Lu, Junxi; Bao, Yuqian; Jia, Weiping; Hu, Renming

doi:10.1111/jdi.12307

Cited by 4 publications

(10 citation statements)

References 33 publications

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“…In present study we further examined the association between elevated 24 h UAE and risk of MetS by dividing participants into four groups according to quartiles of 24 h UAE within normal range. Our study indicated that the odds of MetS significantly increased with increase of 24 h UAE within normal range, which is in agreement with the findings of previous studies[ 3 , 7 – 9 ]. To date, only one prospective cohort study has attempted to determine the association between urine albumin-to-creatinine ratio (UACR) estimated by a single morning urine sample and the development of MetS, which reported that compared with participants with first tertile of UACR, the hazard ratios (HRs) and 95% confidence intervals (CI) for MetS was 1.01 (0.71–1.45) and 1.57 (1.14–2.18) for participants in the second and third tertiles, respectively[ 7 ].…”

Section: Discussionsupporting

confidence: 93%

Are Microalbuminuria and Elevated 24 H Urinary Microalbumin Excretion within Normal Range Associated with Metabolic Syndrome in Chinese Adults?

Guo

Chen

et al. 2015

PLoS ONE

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The association of microalbuminuria and elevated 24 h urinary microalbumin excretion (UAE) with metabolic syndrome (MetS) has not been well examined in Chinese Adults. In the present study, a population-based cross-sectional study was conducted among Chinese adults aged 18–69 years in Shandong province in 2011 to determine the relationship between them. Data on 24 h UAE and other variables were obtained and components of MetS were examined. The prevalence of MetS and mean 24 h UAE was 24.7% and 6.7 mg, respectively. Compared with participants with normoalbuminuria, the odds of MetS and its components including central obesity, elevated blood pressure and elevated fasting glucose, but not the odds of low HDL cholesterol and elevated triglycerides, significantly increased in those with microalbuminuria. Additionally, the odds of MetS and its three components significantly increased across increasing quartiles of 24 h UAE within normal range (1.00, 1.11, 1.02 and 1.58, respectively, for MetS; 1.00, 1.14, 1.21, and 1.68, respectively, for central obesity; 1.00, 1.35, 1.26 and 1.68, respectively, for elevated blood pressure; and 1.00, 1.32, 1.06 and 1.47, respectively, for elevated triglycerides; p for linear trend ≤0.05 for all). Furthermore, for each increment of 10 mg 24 h UAE within normal range, the odds of MetS and its components including central obesity, elevated blood pressure, and elevated triglycerides significantly increased by 53%, 65%, 55%, and 41%, respectively. These findings suggest that both microalbuminuria and elevated 24 h UAE within normal range might be important risk factors for MetS in Chinese adults.

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Section: Discussionsupporting

confidence: 93%

Are Microalbuminuria and Elevated 24 H Urinary Microalbumin Excretion within Normal Range Associated with Metabolic Syndrome in Chinese Adults?

Guo

Chen

et al. 2015

PLoS ONE

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“…Our study further showed that the prevalence of MetS gradually increased with increasing normal-range 24-hour UAE quartiles, which is consistent with previous studies 15 26–28. Thus far, only one prospective cohort study reported HRs with 95% CIs for MetS: 1.57 (95% CI 1.14 to 2.18) for the three highest albumin:creatinine ratio quartiles compared with the lowest one 28.…”

Section: Discussionsupporting

confidence: 92%

“…The prevalence of MAU increased significantly with increasing numbers of MetS components after the subjects were divided by the number of MetS components. The same results were obtained in previous studies 12–15 25 26. This finding indicates that a large number of participants with MAU are easily overlooked in routine health examinations that do not include MAU measurements.…”

Section: Discussionsupporting

confidence: 88%

Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study

Chen

et al. 2019

BMJ Open

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ObjectiveMicroalbuminuria (MAU) has been described as a risk factor for metabolic syndrome (MetS). However, the association between MetS components with MAU and 24-hour urinary albumin excretion (UAE) has not been clearly explained in the general Chinese population. We aimed to analyse the associations between MAU and high–normal 24-hour UAE with MetS and its components.DesignCross-sectional observational study.SettingFour selected counties/districts in China’s Shandong and Jiangsu Provinces.ParticipantsA total of 2261 participants aged 18–69 years were included in this study. Participants with missing physical examination data or incomplete urine collection were not included in the analysis.ResultsThe prevalence of MAU was 9%, and the mean 24-hour UAE was 18 mg/d. The prevalence of MAU was significantly higher for the MetS, high blood pressure (BP), high triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C) and hyperglycaemia groups but not for the central obesity group. Both MAU and mean 24-hour UAE were significantly increased in association with a number of MetS components. The adjusted prevalence OR (POR) for MetS with MAU was 2.95 (95% CI 2.15 to 4.04) compared with those without MAU. MAU was significantly associated with three components of MetS: high BP (POR=1.86, 95% CI 1.31 to 2.64), high TG levels (POR=1.80, 95% CI 1.31 to 2.46) and hyperglycaemia (POR=1.84, 95% CI 1.34 to 2.53). No significant association between MAU and central obesity or low HDL-C was found. The presence of MetS gradually increased according to the normal-range 24-hour UAE quartiles: POR=1.00, POR=1.22, POR=1.14 and POR=2.02, respectively. Hyperglycaemia also increased significantly according to the normal-range 24-hour UAE quartiles.ConclusionsMAU and elevated 24-hour UAE within the normal range were closely associated with MetS in the Chinese population, which may provide a basis for the development of early interventions to decrease the effects of MetS.

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“…Weight, height, waist circumference, hip circumference, and blood pressure were conducted for individuals by the prior protocols [10–12, 23, 28]. Body mass index (BMI) was measured as the ratio of the weight to the height squared.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, metabolic syndrome (MetS), comprised of impaired glucose regulation, HTN, dyslipidemia, and central obesity, existed in approximately two-thirds of type 2 diabetic patients or more [22]. Our previous reports also found more MetS in type 2 diabetes [23]. Both the PROSPER study and BRHS study indicated that MetS and its components were related to type 2 diabetes [24].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical characteristics of hypertension and metabolic syndrome in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study

Wang¹,

Wang

Chen³

et al. 2019

Diabetol Metab Syndr

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Background To investigate the prevalence and clinical characteristics of hypertension (HTN) and metabolic syndrome (MetS) in newly diagnosed diabetes with ketosis-onset. Methods A cross-sectional study was adopted in 734 newly diagnosed diabetics including 83 type 1 diabetics with positive islet-associated autoantibodies, 279 ketosis-onset diabetics without islet-associated autoantibodies and 372 non-ketotic type 2 diabetics. The clinical characteristics of HTN and MetS were compared across the three groups, and the risk factors of them were appraised in each group. Results The prevalence of HTN and MetS were substantially higher in the ketosis-onset diabetics (34.4% for HTN and 58.8% for MetS) than in the type 1 diabetics (15.7% for HTN, P = 0.004; 25.3% for MetS, P < 0.001), but showed no remarkable difference compared with the type 2 diabetics (42.7% for HTN, P = 0.496; 72.3% for MetS, P = 0.079). Furthermore, the risk factors for both HTN and MetS in the ketosis-onset diabetics resembled those in the type 2 diabetics, but significantly different from those in the type 1 diabetics. Conclusions The prevalence of HTN and MetS in the ketosis-onset diabetics were magnificently higher than in the type 1 diabetics but showed no difference in comparison to the type 2 diabetics. Likewise, the clinical features and risk factors of HTN and MetS in the ketosis-onset diabetes resembled those in the type 2 diabetes but differed from those in the type 1 diabetes. Our findings indicate that ketosis-onset diabetes should be classified into type 2 diabetes rather than idiopathic type 1 diabetes.

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High‐normal urinary albumin‐to‐creatinine ratio is independently associated with metabolic syndrome in Chinese patients with type 2 diabetes mellitus: A cross‐sectional community‐based study

Cited by 4 publications

References 33 publications

Are Microalbuminuria and Elevated 24 H Urinary Microalbumin Excretion within Normal Range Associated with Metabolic Syndrome in Chinese Adults?

Are Microalbuminuria and Elevated 24 H Urinary Microalbumin Excretion within Normal Range Associated with Metabolic Syndrome in Chinese Adults?

Association of microalbuminuria and high–normal 24-hour urinary albumin excretion with metabolic syndrome and its components in the general Chinese population: cross-sectional study

Prevalence and clinical characteristics of hypertension and metabolic syndrome in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study

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