High percentage of dietary palm oil suppressed growth and antioxidant capacity and induced the inflammation by activation of TLR-NF-κB signaling pathway in large yellow croaker (Larimichthys crocea)

Li, Xueshan; Ji, Renlei; Chen, Kun; Chen, Qiuchi; Chen, Qiang; Fang, Wei; Mai, Kangsen; Zhang, Yanjiao; Xu, Weiqi; Ai, Qinghui

doi:10.1016/j.fsi.2019.01.055

Cited by 69 publications

(51 citation statements)

References 44 publications

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“…In this study, optimal andrographolide supplementation downregulated the mRNA expression levels of TLR-3, TLR-7 and TLR-8 in the intestine of M. albus . Previous studies have demonstrated that the activation of the TLR signaling pathway leads to increased proinflammatory cytokines (such as IL-1β) and decreased anti-inflammatory cytokines (such as IL-10) [ 64 ]. Therefore, this study indicated that the downregulation of proinflammatory cytokines by andrographolide might occur via suppression of the TLR pathway in the intestine.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Shi

Zhong

et al. 2020

Animals

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An eight-week feeding trial was conducted to investigate the effects of dietary andrographolide on the growth performance, antioxidant capacity in the liver, intestinal inflammatory response and microbiota of Monopterus albus. A total of 900 health fish (25.00 ± 0.15 g) were randomly divided into five groups: AD1 (the basal diet) as the control, and AD2, AD3, AD4 and AD5 groups, which were fed the basal diet supplemented with 75, 150, 225 and 300 mg/kg andrographolide, respectively. The results showed that compared with the control group, dietary andrographolide supplementation (1) significantly increased trypsin and lipase activities in the intestine, and increased the weight gain rate but not significantly; (2) significantly increased the levels of glutathione reductase (GR), glutathione (GSH) and glutathione peroxidase (GPx) and the content of in the liver; significantly decreased the contents of reactive oxygen species (ROS) and malondialdehyde (MDA); remarkably upregulated the Nrf2, SOD1, GSTK and GSTO mRNA levels in the liver; downregulated the Keap1 mRNA level; (3) significantly increased the villi length and goblet cell numbers in the intestine, remarkably upregulated the Occludin mRNA level in the intestine, downregulated the Claudin-15 mRNA level; (4) remarkably upregulated the IL-10, TGF-β1 and TGF-β3 mRNA levels in the intestine; downregulated the IL-12β and TLR-3 mRNA levels; (5) significantly decreased the richness and diversity of the intestinal microbioma, increased the percentages of Fusobacteria and Firmicutes and significantly decreased the percentages of Cyanobacteria and Proteobacteria. In conclusion, these results showed that dietary low-dose andrographolide (75 and 150 mg/kg) promoted growth and antioxidant capacity, regulated the intestinal microbioma, enhanced intestinal physical and immune barrier function in rice field eel.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Shi

Zhong

et al. 2020

Animals

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“…AST and ALT are non‐serum activity enzymes primarily found in the liver, kidney, heart and other organs, and the increase in serum AST and ALT activity might be associated with liver damage or dysfunction (Li et al, ; Tan et al, ). In the present study, the activity of these two enzymes in serum had a decreased trend with increasing dietary Nano‐Se, suggesting that dietary Nano‐Se played a protective role in liver and other tissue organs of grass carp, and this result is consistent with another previous study on grass carp (Liu et al, ).…”

Section: Discussionmentioning

confidence: 99%

Dietary nano‐selenium enhances antioxidant capacity and hypoxia tolerance of grass carp Ctenopharyngodon idella fed with high‐fat diet

Cheng

Zhang

et al. 2019

Aquacult Nutr

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To evaluate the effects of dietary nano‐selenium (Nano‐Se) on antioxidant capacity and hypoxia tolerance of grass carp fed with high‐fat diet, experimental fishes were fed Nano‐Se supplemented diets at doses of 0 (Control), 0.3, 0.6, 0.9 and 1.2 mg/kg for 10 weeks. After feeding trial, a part of the fishes were exposed to hypoxia stress. Results showed that the survival ratio of grass carp significantly increased in 0.6 and 0.9 mg/kg Nano‐Se group, and the content of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) significantly decreased in 0.6–1.2 mg/kg Nano‐Se groups compared with the control group. In addition, dietary Nano‐Se significantly enhanced glutathione peroxidase (GPX) activity and reduced the malondialdehyde (MDA) content in fishes fed diets with 0.3 and 0.6 mg/kg Nano‐Se. Dietary Nano‐Se significantly elevated mRNA expression of GPX1 and catalase (CAT) by promoting the mRNA expression of NF‐E2‐related nuclear factor 2 (Nrf2) in the hepatopancreas. After hypoxia stress, the GPX and superoxide dismutase (SOD) activities were significantly enhanced, and the MDA content and mortality rate consequently decreased in fishes fed diets with 0.3 and 0.6 mg/kg Nano‐Se. In summary, these results suggested that optimal Nano‐Se in diet enhanced the antioxidant capacity and hypoxia tolerance of grass carp.

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“…In recent years, many studies have explored the effects of complete or partial replacement of FO with VOs in freshwater and marine fish (NRC, 2011). While partial replacement of FO with VOs does not affect growth performance (Fountoulaki et al., 2009; Qiu et al., 2017; Trushenski et al., 2011), total replacement of dietary FO with VOs may significantly impact on growth and feeding efficiency, leading to growth retardation (Jin et al., 2017; Li, Ji, et al, 2019). Total replacement of FO with VOs decreases non‐specific immunity of fish (Montero et al., 2003), including reducing their antioxidant capacity and inducing inflammatory responses (Tan, Dong, Xu, Mai, & Ai, 2017), further affecting membrane fluidity and eicosanoid pathways (Calder, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant system is an important non‐specific immune system in fish; it comprises superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH‐Px), which are the main antioxidant enzymes involved in scavenging oxygen free radicals and reactive oxygen species (ROS) (Locatelli et al., 2003; Martínez‐Álvarez, Morales, & Sanz, 2005). Replacement of 100% of FO with VOs significantly decreases plasma CAT activity in the large yellow croaker ( Larmichthys crocea ) (Li et al, 2019) and SOD activity in the Japanese sea bass ( Lateolabrax japonicus ) (Xu et al., 2015), respectively. Furthermore, several studies have reported that VOs can cause overexpression of pro‐inflammatory cytokine genes and an inflammatory response in the gilthead seabream ( Sparus aurata ) (Montero et al., 2010) and Senegalese sole ( Solea senegalensis ) (Montero et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary vegetable oil on growth performance, digestive capacity, antioxidant capacity and expression of immune‐related genes in the hybrid grouper (Epinephelus fuscoguttatus♀ ×E. lanceolatus♂)

Dong

Tan

et al. 2020

Aquacult. Nutr.

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An 8-week feeding experiment was conducted to investigate the effects of dietary lipid sources on growth performance, digestive capacity, antioxidant capacity and expression of immune-related genes in the hybrid grouper (Epinephelus fuscoguttatus ♀× E. lanceolatus ♂). Five isoproteic and isolipidic experimental diets were formulated containing fish oil (FO), soybean oil (SO), linseed oil (LO), rapeseed oil (RO) and peanut oil (PO), respectively. Results showed that fish fed the FO diet had the highest weight gain and specific growth rate and the lowest feed conversion ratio. The hepatic aspartate aminotransferase and alanine transaminase activities in the FO group were significantly higher than those in the PO group (p < .05), and the highest total antioxidant capacity was observed in the FO group. Intestinal lipase, trypsin and amylase activities in the LO group were significantly higher than those in the FO and SO groups (p < .05). The mRNA expression levels of Toll-like receptor 3, Toll-like receptor 22 and myeloid differentiation factor 88 in the liver of the PO group were significantly elevated (p < .05), while the mRNA expression of pro-inflammatory cytokines (tumour necrosis factor-α and interleukin-1β) in the RO group was significantly higher than that in the FO group, and the highest mRNA expression of anti-inflammatory cytokines (interleukin-10 and transforming growth factor-β1) was recorded in the FO group. In summary, the FO and LO groups showed better growth performance, while the poor growth performance of the PO group could be attributed to aggravation of the inflammatory response. Finally, LO was recommended as the suitable lipid source replacement for FO.

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High percentage of dietary palm oil suppressed growth and antioxidant capacity and induced the inflammation by activation of TLR-NF-κB signaling pathway in large yellow croaker (Larimichthys crocea)

Cited by 69 publications

References 44 publications

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Dietary nano‐selenium enhances antioxidant capacity and hypoxia tolerance of grass carp Ctenopharyngodon idella fed with high‐fat diet

Effects of dietary vegetable oil on growth performance, digestive capacity, antioxidant capacity and expression of immune‐related genes in the hybrid grouper (Epinephelus fuscoguttatus♀ ×E. lanceolatus♂)

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