Based on Monte Carlo simulation, we report the study of the inversion layer mobility in n-channel strained Si/ Si 1-x Ge x MOS structures. The influence of the strain in the Si layer and of the doping level is studied. Universal mobility curves µ eff as a function of the effective vertical field E eff are obtained for various state of strain, as well as a fall-off of the mobility in weak inversion regime, which reproduces correctly the experimental trends. We also observe a mobility enhancement up to 120 % for strained Si/ Si 0.70 Ge 0.30 , in accordance with best experimental data. The effect of the strained Si channel thickness is also investigated: when decreasing the thickness, a mobility degradation is observed under low effective field only.