High-Performance Colorimetric Detection of Thiosulfate by Using Silver Nanoparticles for Smartphone-Based Analysis

Dong, Chen; Wang, Zhuqing; Zhang, Yujie; Ma, Xuehua; Iqbal, M. Zubair; Miao, Lijing; Zhou, Zhuangwei; Shen, Zheyu; Wu, Aiguo

doi:10.1021/acssensors.7b00257

Cited by 66 publications

(35 citation statements)

References 34 publications

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“…Thiosulfate was measured with silver nanoparticles (AgNPs) as previously described [70]. Briefly, particles were prepared by vigorously mixing 1 mL of 20 mM AgNO 3 with 200 µL of 0.5 mM HAuCl 4 in 98 mL of Milli-Q (Millipore Sigma.…”

Section: Thiosulfate Measurement In Buffermentioning

confidence: 99%

Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects

Olson

Gao

Straub

2021

IJMS

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We have shown that autoxidized polyphenolic nutraceuticals oxidize H2S to polysulfides and thiosulfate and this may convey their cytoprotective effects. Polyphenol reactivity is largely attributed to the B ring, which is usually a form of hydroxyquinone (HQ). Here, we examine the effects of HQs on sulfur metabolism using H2S- and polysulfide-specific fluorophores (AzMC and SSP4, respectively) and thiosulfate sensitive silver nanoparticles (AgNP). In buffer, 1,4-dihydroxybenzene (1,4-DB), 1,4-benzoquinone (1,4-BQ), pyrogallol (PG) and gallic acid (GA) oxidized H2S to polysulfides and thiosulfate, whereas 1,2-DB, 1,3-DB, 1,2-dihydroxy,3,4-benzoquinone and shikimic acid did not. In addition, 1,4-DB, 1,4-BQ, PG and GA also increased polysulfide production in HEK293 cells. In buffer, H2S oxidation by 1,4-DB was oxygen-dependent, partially inhibited by tempol and trolox, and absorbance spectra were consistent with redox cycling between HQ autoxidation and H2S-mediated reduction. Neither 1,2-DB, 1,3-DB, 1,4-DB nor 1,4-BQ reduced polysulfides to H2S in either 21% or 0% oxygen. Epinephrine and norepinephrine also oxidized H2S to polysulfides and thiosulfate; dopamine and tyrosine were ineffective. Polyphenones were also examined, but only 2,5-dihydroxy- and 2,3,4-trihydroxybenzophenones oxidized H2S. These results show that H2S is readily oxidized by specific hydroxyquinones and quinones, most likely through the formation of a semiquinone radical intermediate derived from either reaction of oxygen with the reduced quinones, or from direct reaction between H2S and quinones. We propose that polysulfide production by these reactions contributes to the health-promoting benefits of polyphenolic nutraceuticals.

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Section: Thiosulfate Measurement In Buffermentioning

confidence: 99%

Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects

Olson

Gao

Straub

2021

IJMS

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“…The recent development of smartphones and their impressive technological applications open a staggering variety of options in numerous areas. User-friendly smartphone analytical methods are continuing to emerge, and some examples have already been described in the bibliography for pH measurement 34 or anion detection, 35 thus confirming a contemporary development associated with more advanced algorithms for smartphones. In terms of colorimetry, a broad range of software applications, commonly called apps, are available for users for various platforms, such as Android, iOS, BlackBerry OS, or Windows Phone.…”

Section: Resultsmentioning

confidence: 89%

Selective Screening of Biological Thiols by Means of an Unreported Magenta Interaction and Evaluation Using Smartphones

Ortega-Higueruelo

Langa

2018

ACS Omega

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The determination of biological thiols is considered to be of great interest because of the participation of these molecules in physiological disorders as indicators of their existence and progress, such as Alzheimer’s disease, cancer, and cystic fibrosis, among others. Optical techniques for the quantification of these analytes are superior to other techniques in terms of selectivity, sensitivity, and cost. We describe here a simple protocol to determine biological thiols by means of a colorimetric analysis based on a magenta color interaction with 5,5′-dithiobis(2-nitrobenzoic acid). This methodology leverages the technology developed in smartphones, and it can be transferred to a simple analytical procedure through the use of absorbent strips and a cell phone. Excellent characteristics were observed, and this method opens up alternative avenues for the detection of biological thiols in a very simple and portable manner.

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“…The colorimetric changes in these NPs following their interaction with the target analyte can be easily tracked by cameras in smartphones. Such an approach makes sensitive diagnostic platforms more portable and user-friendly (Dong et al, 2017). Photothermal effect (PTT) and localized surface plasmon resonance (LSPR) was utilized to synthesize a sensitive dual-functional gold nanoisland (AuNIs)based sensor with a detection limit of 0.22 pM.…”

Section: Nanotechnology-based Viral Diagnostics In the Era Of Covid-19mentioning

confidence: 99%

Viral Diagnostics and Preventive Techniques in the Era of COVID-19: Role of Nanoparticles

Chakraborty

Kumar

Chandrasekaran

et al. 2020

Front. Nanotechnol.

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COVID-19 outbreak in the Hubei province of China as of December 2019 has caused massive global fatalities. Recommended preventive strategies that include the use of sanitizers and masks caused a global shortage of protective gear for the frontline health workers who were at a higher risk of infection. Implementing effective containment strategies and promoting large scale diagnosis of the general public thus forms the first line of defense in controlling the spread of the contagion as of now. The understanding of the biological identity of the SARS-CoV-2 virus has helped the researchers figure out the mechanism of infection and also helped them design efficient diagnostic kits. This review primarily provides comprehensive details of the gold standard viral diagnostic methods. With nanoparticles playing a vital role in healthcare platforms, its mode of action against other viruses and its application in COVID-19 has been elaborated. The relevance of incorporating nanoparticles in surface coatings, sanitizers, masks, and air filters have been highlighted. NP-based biosensors that can be utilized as point-of-care tests and multiplexed assay have also been discussed. Considering the ongoing threat, new research studies focus on strategically combining different diagnostic systems to enhance the sensitivity and accuracy of the detection kits. In this regard, the key details of the patents that encompass new methodologies for virus detection have been summarized.

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High-Performance Colorimetric Detection of Thiosulfate by Using Silver Nanoparticles for Smartphone-Based Analysis

Cited by 66 publications

References 34 publications

Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects

Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects

Selective Screening of Biological Thiols by Means of an Unreported Magenta Interaction and Evaluation Using Smartphones

Viral Diagnostics and Preventive Techniques in the Era of COVID-19: Role of Nanoparticles

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