High-Performance Liquid Chromatographic Stability-Indicating Assay for Naphazoline and Tetrahydrozoline in Ophthalmic Preparations

Bauer, John F.; Krogh, Suzanne

doi:10.1002/jps.2600721128

Cited by 27 publications

(10 citation statements)

References 2 publications

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“…Additionally, a chiral separation has been reported for this same amine following a condensation reaction with COClz (1080) and for amide derivatives of amphetamine using an optically active mobile phase additive and an aminopropyl column (1070). Miscellaneous adrenergic compounds studied over the time of this review include epinephrine (460,610, 1110), naphazoline (300), and terbutaline (1130). An assay has been described for quantitation of nadolol in tablet formulations (860).…”

Section: Nitrogen-oxygen Containing Compoundsmentioning

confidence: 99%

Pharmaceuticals and related drugs

Gilpin¹,

Pachla²

1985

Anal. Chem.

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Section: Nitrogen-oxygen Containing Compoundsmentioning

confidence: 99%

Pharmaceuticals and related drugs

Gilpin¹,

Pachla²

1985

Anal. Chem.

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“…Several analytical methods are used to determine naphazoline (NPZ); most are photometric [25] and chromatographic methods. Different types of chromatographic method have been reported in the literature, including thin-layer chromatography [26,27], gas chromatography [28], and high-performance liquid chromatography [29,30,31,32,33,34]. The literature also contains a report of the use of a fluorimetric method [35] to determine naphazoline in ophthalmic solution at λ ex/em =280/327 nm, with a linear range between 0.1 and 0.5 mg mL -1 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Díaz¹,

Terrones

Segura‐Carretero³

et al. 2004

Analytical and Bioanalytical Chemistry

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We present results from a comparative study of three proposed phosphorimetric methods for determination of naphazoline (NPZ) in solution. The first method is based on use of micelles to stabilize phosphorescence signals in solutions at room temperature (MS-RTP). The second is based on the use of a heavy atom salt and sodium sulfite as an oxygen scavenger to obtain room-temperature phosphorescence (HAI-RTP) in solution. The last method employs an optical sensor for NPZ based on the phosphorescent properties of the analyte on a solid sensor phase. The aim of this work was to compare time consumption, simplicity, sensitivity, selectivity, detection, and quantification limits for use of these three phosphorimetric methods to determine naphazoline in pharmaceutical preparations. The most simple, sensitive, and reproducible of the three methods for naphazoline analysis is the HAI-RTP method. Detection limits are 4.9, 1.7, and 9.4 ng mL(-1), respectively, for the MS-RTP, HAI-RTP, and optosensor methods.

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“…Tetryzoline HCl (TZH) is combined together with antibiotics, corticosteroids and anti-histamines to formulate anti-infective eye preparations to treat acute and sub-acute conjunctivitis, keratitis and corneal ulcers [9]. Different analytical techniques were reported for TZH determination in pharmaceutical preparations and in biological fluids such as: colorimetric determination [10], spectrophotometry [11][12][13][14], high performance thin layer chromatographic method (HPTLC) [15], high performance liquid chromatographic method (HPLC) [16][17][18][19][20][21] and gas chromatography [22]. Two ophthalmic combinations were selected for the analysis of the minor component TZH; the first one is mixture (A): Ofloxacin (OFX), prednisolone acetate (PA) and TZH in the ratio of (7.5:5:1) respectively, while the second one is mixture (B): sodium cromoglicate (SCG) and TZH in the ratio of (80:1) respectively.…”

Section: Introductionmentioning

confidence: 99%