High-performance liquid chromatography analysis of salivary bisphenol A levels from light-cured and chemically cured orthodontic adhesives

Manoj, Madhav K.; Ramakrishnan, Roopesh; Babjee, Sujith; Nasim, Rasha

doi:10.1016/j.ajodo.2018.02.008

Cited by 17 publications

(12 citation statements)

References 16 publications

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“…All studies of salivary content showed an increase in the levels of bisphenol A in the evaluations realized immediately after the treatments, either with composite resins or with sealants, within 1 h [1,5,17,18,20,23,26,28,29]. This increase in BPA in most studies ranges from 2 to 42 ng/mL [1,5,18,23,26], although there are some that reports values of 120.05 to 931 ng/mL [17,29]. In other follow-ups, the levels decrease over time, like pre-treatment after 1 week [1,5,17,18,20,23,26,28,29].…”

Section: Resultsmentioning

confidence: 99%

“…This increase in BPA in most studies ranges from 2 to 42 ng/mL [1,5,18,23,26], although there are some that reports values of 120.05 to 931 ng/mL [17,29]. In other follow-ups, the levels decrease over time, like pre-treatment after 1 week [1,5,17,18,20,23,26,28,29]. Some studies have evaluated the levels of bisphenol A according to the number of surfaces restored or sealed, with an exponential increase from six surfaces [6,9,19].…”

Section: Resultsmentioning

confidence: 99%

“…The male genital tract might also be affected and become more predisposed to prostate and testicular cancer as well as a drop in sperm count [44,48]. Recently, reports demonstrated that BPA make hormonal changes, namely on thyroid hormones as well as in testosterone levels in boys [26,49], accelerating maturational changes in girls and increasing the risk of diabetes and breast cancer [26]. Therefore, dental procedures using BPA-containing composite resins or sealants should be practiced with caution in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Once Resin Composites and Dental Sealants Release Bisphenol-A, How Might This Affect Our Clinical Management?—A Systematic Review

Paula

Toste

Marinho

et al. 2019

IJERPH

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(1) Background: Bisphenol A (BPA) based dental resins are commonly used in preventive and reparative dentistry. Since some monomers may remain unpolymerized in the application of dental resin, they dissolve in the saliva. (2) Methods: The literature search was carried out in Pubmed, Cochrane and Embase databases. Randomized controlled trials, cohort studies and case-control studies that evaluated BPA levels in human urine, saliva and/or blood were included. (3) Results: The initial search had 5111 results. A total of 20 studies were included in the systematic review. Most studies showed an increase of the levels of bisphenol A 1 h after treatments with composite resins and dental sealants. One week after treatments the levels were decreased. (4) Conclusions: Some clinical precautions should be taken to decrease the release of BPA, namely the use of rubber dam, the immediate polishing of all resins used, or the use of glycerin gel to avoid non-polymerization of the last resin layer, and mouthwash after treatment. Another preventive measure in addition to the above-mentioned is the use of the smallest possible number of restorations or sealants, a maximum of four per appointment. These measures are even more important in children, adolescents and pregnant women.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Once Resin Composites and Dental Sealants Release Bisphenol-A, How Might This Affect Our Clinical Management?—A Systematic Review

Paula

Toste

Marinho

et al. 2019

IJERPH

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“…[5] In contrast, several studies have stated that the exposure to BPA from dental materials is minimal and appears to pose no known health risk. [11121314] It is worthy to mention that manufacturers are not mandated to report the exact composition of their composite resins, and some have refused to share the composition of their composite resins when asked. [19]…”

Section: Discussionmentioning

confidence: 99%

“…[1011] Consequently, several studies have reported BPA detected in the saliva of patients following the placement of composite resin sealants in different amounts. [121314]…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude, and behavior of restorative, orthodontic, and pediatric departments' members toward bisphenol A dental exposures

Bagher

Sabbagh

Aldajani

et al. 2019

J Int Soc Prevent Communit Dent

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Aim and Objectives: The aim of this study is to evaluate the knowledge, attitude, and behavior of Restorative, Orthodontic, and Pediatric Dentistry Departments’ members at King Abdulaziz University (KAU), Jeddah, Saudi Arabia, toward bisphenol A (BPA) dental exposure. Materials and Methods: A survey was pretested for face and content validity. It included ten knowledge-, four attitude-, and five behavior-based items. The collected data were analyzed using Windows SPSS software version 22 (IBM Corp., Armonk, NY, USA). Significant levels were set at 0.05. Results: A total of 109 members participated in this study. Most of them (80 [73.4]) had never attended a lecture or read an article on BPA dental exposure previously. The restorative department members showed the highest (mean ± standard deviation score) in knowledge-based questions (3.32 ± 3.323), and those who reported that they had heard of BPA previously, read an article, or attended a lecture on BPA received significantly higher mean knowledge scores ( P < 0.0001). The pediatric dentistry departments’ members showed significantly higher agreements to attitude questions. Only ten participants (9.2%) followed the recommended guidelines to reduce patients’ exposure to BPA during the application of BPA-containing dental materials. Conclusions: Reading an article or attending a lecture on BPA significantly improves the knowledge scores. Therefore, there is a need to increase the awareness on BPA dental exposure among different departments’ members in KAU to ensure that BPA exposure to patients is minimized and to ensure the spread of this knowledge to the dental students.

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Elution study of acrylic monomers from orthodontic materials using high performance liquid chromatography (HPLC)

et al. 2021

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Purpose Main goal of the study was the identification and quantitative analysis of monomer elution from materials commonly used in fixed orthodontic therapy. Studies have shown severe health effects of monomers including cytotoxic, allergenic or mutagenic potential and endocrine changes. This in vitro study focusses primarily on five resins which are usually processed intraorally and remain in the oral cavity long-term. Methods We tested the elution of monomers from specimens (7.5 mm × 1.5 mm) immersed in artificial saliva at body temperature (37 °C) for 30 min to 5 weeks. The used method is in accordance with DIN EN ISO 10993-13. The five tested materials were BrackFix® (Voco GmbH, Cuxhaven, Germany), Triad®Gel (DeguDent GmbH, Hanau, Germany), and Transbond™ XT, LR and Plus (3M Unitek, Monrovia, CA, USA). All aliquots were analyzed using high performance liquid chromatography (HPLC). Data were statistically analyzed. Results All five analyzed materials eluted substances over a period of 5 weeks. Identified substances included bisphenol A (BPA), triethylene glycol dimethacrylate (TEGDMA) and urethane dimethacrylate (UDMA). BPA eluted from Transbond™ Plus, XT, LR and BrackFix®. The cumulated mean values after 35 days ranged from 16.04 to 64.83 ppm, depending on the material. TEGDMA eluted with a mean of 688.61 ppm from Transbond™ LR. UDMA with a mean of 1682.00 ppm from Triad®Gel. For each material the highest concentrations of all these substances were found in the first elution period. Other substances that were not equivocally identified or of low concentration also eluted. Conclusion Using the described method, it is possible to qualitatively and quantitatively determine the in vitro elution of monomers from orthodontic materials. The concentrations of the substances identified were below the current maximum recommended intake. However, a cumulative effect and low-dose effects should be considered for both patients and dental professionals, especially for young patients. Measures to reduce exposure patients and practitioners are suggested.

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High-performance liquid chromatography analysis of salivary bisphenol A levels from light-cured and chemically cured orthodontic adhesives

Cited by 17 publications

References 16 publications

Once Resin Composites and Dental Sealants Release Bisphenol-A, How Might This Affect Our Clinical Management?—A Systematic Review

Once Resin Composites and Dental Sealants Release Bisphenol-A, How Might This Affect Our Clinical Management?—A Systematic Review

Knowledge, attitude, and behavior of restorative, orthodontic, and pediatric departments' members toward bisphenol A dental exposures

Elution study of acrylic monomers from orthodontic materials using high performance liquid chromatography (HPLC)

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