High-performance spinning device for DVD-based micromechanical signal transduction

Abstract

Here we report a high-throughput spinning device for nanometric scale measurements of microstructures with instrumentation details and experimental results. The readout technology implemented in the designed disc-like device is based on a DVD data storage optical pick-up unit (OPU). With a spinning mechanism, this device can simultaneously measure surface topography, mechanical deflections and resonance frequencies of several microfabricated beams at a high speed. In biochemical sensing applications, the OPU can measure bending changes of functionalized microcantilevers, providing a statistically robust and label-free bio-detection analysis of multiple compounds. The signal-to-noise ratio (S/N) is demonstrated from statistical measurements as 1.2 with arginine detection at 750 nM concentration. Practically, the OPU can measure up to 480 individual cantilever sensors per second with nanometer resolution. The opto-mechanical optimization of the device design and settings for biochemical detection are described.

Hacking CD/DVD/Blu-ray for Biosensing

“…This scanning system has a theoretical throughput of 500,000 cantilevers per second. 64 Moreover, the OPU scanning data has been used to reconstruct 3D topography and surface roughness of each cantilever to provide extra physical information for detection of pesticide derivative 2,6-dichlorobenzamide, 65 as shown in Figure 10 . OPU cantilever-based biosensing has also been used in applications such as detection of vapor and liquid phase of 2,4-dinitrotoluene, 66 platelet derived growth factor proteins, 67 and soluble urokinase plasminogen activator receptor inflammatory biomarker.…”

“…Furthermore, the OPU has a high sensing tolerance of ±5° to the cantilever initial angular tilt, allowing to scan cantilever-based biosensors on a rotating disc. This scanning system has a theoretical throughput of 500,000 cantilevers per second . Moreover, the OPU scanning data has been used to reconstruct 3D topography and surface roughness of each cantilever to provide extra physical information for detection of pesticide derivative 2,6-dichlorobenzamide, as shown in Figure .…”

Open-source controller for low-cost and high-speed atomic force microscopy imaging of skin corneocyte nanotextures

“…The simplified AFM controller is connected to the AFM head via a flat cable. The AFM head utilizes a DVD optical pick-up unit (OPU) [46] , [47] , [48] to monitor the cantilever deflection [49] , [50] , [51] of the AFM probe [52] , [53] , [54] . The AFM base consists of a piezoelectric buzzer-based scanner [55] , [56] to scan a sample in the x- and y-directions.…”

Low-cost, open-source XYZ nanopositioner for high-precision analytical applications

“…The decreasing thermal conductance towards the center of the microstring leads to an increase in the average temperature, and the resulting thermal expansion was measured by detuning the resonance frequency, as shown in Fig. 14 D. The nanopositioner has also been applied in a digital video disc (DVD) optical pick-up unit (OPU) sensing system [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] -based vibrometer, as reported previously [46] .

Fig.

…”