High-performance thin-layer chromatographic method for simultaneous analysis of metoprolol succinate and amlodipine besylate in pharmaceutical preparations

Conventional univariate versus multivariate spectrophotometric assisted techniques for simultaneous determination of perindopril arginin and amlodipine besylate in presence of their degradation products

“…A 1 = 0.0147 C 1 + 0.0494 r 1 = 1.0000 at 208 nm for PER (16) A 2 = 0.0418 C 2 + 0.0216 r 2 = 0.9999 at 208 nm for AML (17) Where A 1 , A 2 , C 1 , C 2 , r 1 and r 2 are the absorbance, the concentrations in µg mL -1 and the correlation coefficients of PER and AML, respectively.…”

“…Also, different analytical techniques have been published for the determination of amlodipine besylate either in binary mixture or enantiometric mixture depending on the theory of chromatography as HPLC [13][14][15], or using TLC theory [16][17][18], capillary electrophoresis using different back ground electrolytes and chiral selectors [19][20][21], and voltammetry in binary mixture with valsartan or in bulk powder [22,23]. While, perindopril in combination with amlodipine were analyzed by spectrophotometric and HPLC methods [24,25] and in the presence of their degradation products [26].…”

Multivariate Versus Classical Univariate Calibration Methods for Spectrofluorimetric Data: Application to Simultaneous Determination of Olmesartan Medoxamil and Amlodipine Besylate in their Combined Dosage Form

“…Several analytical methods have been reported for the determination of AML in pharmaceutical formulations and/or biological fluids. These methods include spectrophotometry [19][20][21], spectrofluorimetry [22,23], anodic stripping voltammetry [24,25], HPLC [26][27][28][29][30][31], HPTLC [32], capillary electrophoresis [33] and micellar electrokinetic chromatography [34].…”

Validated HPTLC Method for Simultaneous Estimation of Atenolol and Aspirin in Bulk Drug and Formulation

“…Literature review reveals that methods have been reported for analysis of Atenolol and Aspirin by UV spectrophotometry [3,4], method development and validation either alone or in combination with other drugs [5][6][7][8][9][10], and stability indicating analytical method by HPTLC [11].…”