High Plasma Concentration of Remnant Lipoprotein Cholesterol in Obese Children and Adolescents

Choi, Yong Jun; Jo, Young Eun; Kim, Yun Kyung; Ahn, Sang Mi; Jung, Sun Hye; Kim, Hae Jin; Chung, Yoon‐Sok; Lee, Kwan Woo; Kim, Dae Jung

doi:10.2337/dc06-0938

Cited by 18 publications

(15 citation statements)

References 33 publications

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“…Choi et al [59] have suggested that low density lipoprotein particle size negatively correlates with BMI. Remnant lipoprotein cholesterol, which is the product of the lipolytic degradation of triglyceride-rich lipoproteins produced by the liver and intestine, was previously shown to be higher in obese children and adolescents [6061]. In addition, obese children and adolescents had higher blood pressure readings than their peers of a normal weight [62].…”

Section: Physical and Psychological Comorbiditiesmentioning

confidence: 99%

Epidemiology of Childhood Obesity in Korea

Kim

2016

Endocrinol Metab

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Over the past several decades, the prevalence of obesity has increased dramatically worldwide and is increasing not only in developed countries, but also in developing countries. This increase may lead to an increase in the incidence of chronic diseases throughout the lifespan. In Korean children and adolescents, the prevalence of obesity increased from 6.8% in 1998 to 10.0% in 2013. Obesity is a state that more commonly influences children and adolescents of lower socioeconomic status (SES) than those with a higher SES. However, the prevalence of metabolic syndrome in a nationally representative sample of Korean adolescents decreased from 1998 to 2012. According to the Diabetes Fact Sheet of the Korean Diabetes Association, the prevalence of type 2 diabetes among children aged 18 years or younger was 153.5 per 100,000 in 2006 and 205.0 per 100,000 in 2013. Obesity is a complex disease influenced by many interacting factors, such as adipocytokines, lipopolysaccharide-binding protein, adenovirus 36 infection, birth weight, lifestyle, and endocrine-disrupting chemicals. Obesity in youth can adversely impact practically every organ system and lead to serious consequences, such as metabolic, gastrointestinal, pulmonary, cardiovascular, and psychosocial complications. Therefore, coordinated efforts by governments, organizations, communities, and individuals are needed to prevent and treat childhood obesity. In particular, a long-term policy to improve the social environment will also be necessary.

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Section: Physical and Psychological Comorbiditiesmentioning

confidence: 99%

Epidemiology of Childhood Obesity in Korea

Kim

2016

Endocrinol Metab

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“…A detailed description of the study design and methods is provided in a previous report [23]. Briefly, 135 children and adolescents (67 boys, 68 girls) were enrolled.…”

Section: Methodsmentioning

confidence: 99%

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim¹,

Park²,

Choi³

et al. 2013

Horm Res Paediatr

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Background/Aims: Visfatin is an adipocytokine predominantly expressed in visceral adipose tissue. We examined the relationship between plasma visfatin concentrations and anthropometric and metabolic parameters in children and adolescents, who are relatively less influenced by the effects of accompanying disease. Methods: We studied 135 children and adolescents (8-16 years old). Plasma glucose, insulin, lipid profile, visfatin and other adipocytokine levels were measured. CT scans were performed to evaluate the distribution of abdominal fat. We analyzed the relationship between circulating visfatin levels and anthropometric and metabolic parameters according to central adiposity (total abdominal fat by CT scan). Results: In the lower-adiposity group, plasma visfatin concentrations were significantly correlated with total abdominal fat, visceral fat, subcutaneous abdominal fat, plasma triglyceride level and homeostasis model assessment of insulin resistance (HOMA-IR). In a multiple linear regression analysis, visceral fat and triglycerides were independently associated with plasma visfatin levels. In the higher-adiposity group, plasma visfatin concentrations were not correlated with visceral fat or HOMA-IR but were significantly correlated with circulating interleukin-6 levels. Conclusion: These data suggest that the relationship between plasma visfatin concentrations and metabolic parameters differs according to central adiposity and that plasma visfatin concentrations are correlated with visceral fat and triglyceride levels, especially in children and adolescents with lower adiposity.

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“…Most of the studies performed were focused on children and adolescents with obesity, diabetes mellitus or chronic inflammatory bowel diseases (Levy et al, 2000;Glowinska et al, 2003;Bueno et al, 2006;Choi et al, 2006;Pinhas-Hamiel et al, 2007;Guven and Sanisoglu, 2008). Only the Spanish (Food and Assessment of the Nutritional Status of Adolescents AVENA) cross-sectional study assessed age-and sex-specific serum lipid profiles in 581 healthy adolescents (Ruiz et al, 2006a, b), but its study population was limited to Spain.…”

Section: Introductionmentioning

confidence: 99%

Lipid, lipoprotein and apolipoprotein profiles in European adolescents and its associations with gender, biological maturity and body fat—The HELENA Study

et al. 2012

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Background/Objectives: To provide a detailed lipid profile of a European adolescent population considering age, gender, biological maturity, body mass index (BMI), fat mass (FM) and percentage body fat (BF). Subjects/Methods: Within Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA), a cross-sectional study was conducted to determine fasting serum concentrations of lipids, lipoproteins and apolipoproteins in 1076 adolescents aged 12.5-17.49 years from ten European centres. Results: All serum lipid concentrations were significantly higher in girls than in boys. In boys, age was negatively correlated with high-density lipoprotein (HDL)-cholesterol and total cholesterol (TC), and positively associated with triacylglycerides (TAG) (Po0.01) whereas no significant associations were observed in girls. Biological maturity was negatively associated with TC, HDL-, low-density lipoprotein (LDL)-and non-HDL cholesterol in boys (all Po0.05) and negatively correlated with HDL-cholesterol in girls (Po0.05). BMI, FM and BF were significantly correlated with HDL-cholesterol, LDL-cholesterol, non-HDL cholesterol, apolipoprotein (apo) A1, apoB and TAG in both boys and girls. Conclusions: The lipid profile in adolescents is strongly determined by gender. Biological maturity, FM and percentage BF contribute to the variance in lipid concentrations and should be considered in future evaluations of lipid status.

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High Plasma Concentration of Remnant Lipoprotein Cholesterol in Obese Children and Adolescents

Cited by 18 publications

References 33 publications

Epidemiology of Childhood Obesity in Korea

Epidemiology of Childhood Obesity in Korea

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Lipid, lipoprotein and apolipoprotein profiles in European adolescents and its associations with gender, biological maturity and body fat—The HELENA Study

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