High plasma leptin predicts an increase in subcutaneous adiposity in children and adults

Kettaneh, A.; Heude, Barbara; Romon, Monique; Oppert, Jean‐Michel; Borys, Jean‐Michel; Balkau, Beverley; Ducimetière, Pierre; Munier, Charles

doi:10.1038/sj.ejcn.1602579

Cited by 29 publications

(27 citation statements)

References 51 publications

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“…By contrast, we opted to study 3 clearly defined groups of COPD patients with a mixed male-female population. The latter point is particularly relevant when studying leptin, for instance, where normal females have been shown to have an approximately 3-fold higher leptin level than males [33], while investigation of leptin levels in COPD were principally determined in males [24, 32, 34]. Indeed, development of cachexia in COPD was previously suggested to be attributed to a cytokine-leptin link when the plasma levels of TNF-α and leptin were correlated [32].…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Inflammatory Markers in the Absence of Clinical and Skeletal Muscle Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Piehl-Aulin

Jones²,

Lindvall³

et al. 2009

Respiration

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Background: Muscle wasting and cachexia are common occurrences in patients with chronic obstructive pulmonary disease (COPD). Objectives: The current study aimed to investigate markers of inflammation in the circulation and skeletal muscle that might be associated with development of muscle wasting. Methods: Three groups of patients with mild, moderate and severe COPD and matched healthy controls were recruited. Serum levels of C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), IL-6, IL-8, TNF-α, cortisol, insulin-like growth factor 1 (IGF-1), leptin and ghrelin were analysed. Skeletal muscle inflammation was investigated microscopically using a panel of antibodies and standard staining for inflammatory cell infiltration. Results: All COPD patients were clinically stable, with no sign of inflammation and normal CRP values. Compared to controls, significantly increased hs-CRP levels were observed in all COPD patient groups. Significant rises in IL-6 levels were first observed in moderate COPD, while IL-8 levels were significantly elevated at the late severe stage. Circulating levels of TNF-α, cortisol, IGF-1, leptin and ghrelin were similar to control levels. No microscopic signs of skeletal muscle inflammation were observed. Conclusion: Our results identify hs-CRP as an early marker of inflammation that is significantly increased in the circulation even in mild COPD. Serum interleukin levels appear to be increased with disease progress. These changes were manifested in the absence of any clinical signs of disease exacerbation, evidence of skeletal muscle inflammation or hormonal changes.

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Section: Discussionmentioning

confidence: 99%

Increased Serum Inflammatory Markers in the Absence of Clinical and Skeletal Muscle Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Piehl-Aulin

Jones²,

Lindvall³

et al. 2009

Respiration

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“…67,68 It is well documented that leptin expression in adipose tissue and circulating leptin are elevated in obese subjects. 69 A negative correlation between ZAG and leptin mRNA levels has been found in both visceral and subcutaneous fat in human subjects. 41 It is also reported that ZAG mRNA levels ZAG and adiposity C Bing et al in subcutaneous fat negatively correlate with plasma leptin levels in obese men.…”

Section: Zag: a Candidate Gene For Obesitymentioning

confidence: 99%

Zinc-α2-glycoprotein: an adipokine modulator of body fat mass?

et al. 2010

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The importance of white adipose tissue in the control of energy balance is now firmly recognized. In addition to fuel storage, adipocytes secrete an array of proteins factors (adipokines), which regulate multiple physiological and metabolic processes as well as influence body fat accumulation. Zinc-a2-glycoprotein (ZAG), a lipid mobilizing factor initially characterized as a tumor product associated with cachexia, has recently been identified as a novel adipokine. Although the exact role of ZAG in adipose tissue remains to be clarified, there is evidence that ZAG expression appears to be inversely related to adiposity, being upregulated in cachexia whereas reduced in obesity. Investigations on the regulation of ZAG give insights into its potential function in adipose tissue with a link to lipid mobilization and an anti-inflammatory action. Recent work shows that ZAG stimulates adiponectin secretion by human adipocytes. Data from genetic studies suggest that ZAG may be a candidate gene for body weight regulation; this is supported by the demonstration that ZAG-knockout mice are susceptible to weight gain, whereas transgenic mice overexpressing ZAG exhibit weight loss. The present review summarizes these new perspectives of ZAG and the potential mechanisms by which it might modulate adipose tissue mass and function.

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“…Adipose tissue produces leptin, which plays a role in the regulation of energy homeostasis, food intake, and body composition by signaling satiety and energy reserves through hypothalamic receptors [6,7]. Leptin is positively associated with body FM in term neonates, children, and adults [8,9]. However, little is known about the relation between FM and leptin in infants born preterm.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Poelje

Lagemaat²,

Lafeber³

et al. 2014

Horm Res Paediatr

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Background/Aims: In term subjects, fat mass (FM) is positively associated with leptin, whereas studies in preterm infants show conflicting results. However, none of these studies measured FM by dual-energy X-ray absorptiometry (DEXA). This study aims to relate FM measured by DEXA in relation to leptin and growth in preterm infants. Methods: In 139 preterm infants, weight (kg) and length (cm) were measured at birth, term age, and 6 months' corrected age (CA). FM (kg), measured by whole-body DEXA, and leptin (µg/l) were measured at term age and 6 months' CA. Results: At term age and 6 months' CA, FM was associated with leptin (β = 1.94, 95% CI: 1.51-2.36, and β = 0.37, 95% CI: 0.26-0.48, respectively; p < 0.001). Gain in weight standard deviation score (SDS) between term age and 6 months' CA was associated with FM and leptin at 6 months' CA (β = 0.24, 95% CI: 0.18-0.30, and β = 0.25, 95% CI: 0.16-0.33, respectively; p < 0.001). Conclusion: In preterm infants, FM measured by DEXA is associated with leptin, which indicates that leptin is a marker of body FM during the first 6 months after term age. Gain in weight SDS between term age and 6 months' CA results in higher FM and higher leptin at 6 months' CA.

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High plasma leptin predicts an increase in subcutaneous adiposity in children and adults

Cited by 29 publications

References 51 publications

Increased Serum Inflammatory Markers in the Absence of Clinical and Skeletal Muscle Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Increased Serum Inflammatory Markers in the Absence of Clinical and Skeletal Muscle Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Zinc-α2-glycoprotein: an adipokine modulator of body fat mass?

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

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